Ensembl ID ENSG00000111142 Gene ID 10988 Accession 16672
Gene Symbol METAP2 Alias MAP2;MNPEP;p67eIF2 Full Name methionyl aminopeptidase 2
Position 12 : 95473520 - 95515839 Length 42320 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

ENSG00000111142 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111142 METAP2 -0.3 1.76e-15 KIRC
ENSG00000111142 METAP2 0.45 2.86e-11 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111142 METAP2 cancer 11485930
ENSG00000111142 METAP2 cancer 11738620
ENSG00000111142 METAP2 cancer 12463162
ENSG00000111142 METAP2 Tumor 14633714
ENSG00000111142 METAP2 tumor 15102683
ENSG00000111142 METAP2 colon cancer 15336565
ENSG00000111142 METAP2 cancers 15523682
ENSG00000111142 METAP2 tumor 15548701
ENSG00000111142 METAP2 tumor 15682466
ENSG00000111142 METAP2 astrocytic tumors 16267007
ENSG00000111142 METAP2 cancer 16386852
ENSG00000111142 METAP2 tumor 16525646
ENSG00000111142 METAP2 tumor 16638869
ENSG00000111142 METAP2 cancer 16789740
ENSG00000111142 METAP2 tumor 17450475
ENSG00000111142 METAP2 cancer 18072970
ENSG00000111142 METAP2 tumor 18252827
ENSG00000111142 METAP2 tumor 18264137
ENSG00000111142 METAP2 tumor 18828628
ENSG00000111142 METAP2 tumours 19068103
ENSG00000111142 METAP2 colon cancer 19703310
ENSG00000111142 METAP2 tumor 19716858
ENSG00000111142 METAP2 tumour 20583970
ENSG00000111142 METAP2 tumor 21033716
ENSG00000111142 METAP2 cancer 21925884
ENSG00000111142 METAP2 cancer 22229417
ENSG00000111142 METAP2 tumor 22553414
ENSG00000111142 METAP2 cancer 23355637
ENSG00000111142 METAP2 cancers 23480755
ENSG00000111142 METAP2 cancers 23480758
ENSG00000111142 METAP2 breast cancer 24526833
ENSG00000111142 METAP2 cancer 24611021
ENSG00000111142 METAP2 tumor 24700462
ENSG00000111142 METAP2 cancer 24900682
ENSG00000111142 METAP2 tumor 26029719
ENSG00000111142 METAP2 cancers 26686773
ENSG00000111142 METAP2 Non-Small-Cell Lung Cancers 26935506
ENSG00000111142 METAP2 cancer 27542228
ENSG00000111142 METAP2 tumor 29116484
ENSG00000111142 METAP2 cancer 29579063
ENSG00000111142 METAP2 tumor 30034623
ENSG00000111142 METAP2 cancer 30567416
ENSG00000111142 METAP2 tumor 30939017
ENSG00000111142 METAP2 prostate cancer 31203805
ENSG00000111142 METAP2 Cancer 31725285
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111142 METAP2 MESO 0.04 high
ENSG00000111142 METAP2 SARC 0.033 high
ENSG00000111142 METAP2 THCA 0.025 low
ENSG00000111142 METAP2 LUSC 0.038 low
ENSG00000111142 METAP2 HNSC 0.021 high
ENSG00000111142 METAP2 KICH 0.0094 high
ENSG00000111142 METAP2 LUAD 0.016 high
ENSG00000111142 METAP2 UCS 0.0018 low
ENSG00000111142 METAP2 ESCA 0.035 high
ENSG00000111142 METAP2 OV 0.028 low
ENSG00000111142 METAP2 PRAD 0.018 high
ENSG00000111142 METAP2 GBM 0.033 low
ENSG00000111142 METAP2 SKCM 0.00054 low
ENSG00000111142 METAP2 CESC 0.026 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111142 METAP2 PAAD Del 1.565029 0.062958 0.356155 0.233696
ENSG00000111142 METAP2 SKCM Del 1.557713 0.080240 0.432064 0.247956
ENSG00000111142 METAP2 BRCA Del 0.667718 0.062954 0.390442 0.165741
ENSG00000111142 METAP2 PRAD Amp 0.923119 0.049111 0.529265 0.069106
ENSG00000111142 METAP2 OV Del 2.485844 0.211107 0.562484 0.324698