Ensembl ID ENSG00000110713 Gene ID 4928 Accession 8068
Gene Symbol NUP98 Alias ADIR2;NUP96;NUP196;Nup98-96 Full Name nucleoporin 98 and 96 precursor
Position 11 : 3671083 - 3797792 Length 126710 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

ENSG00000110713 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000110713 NUP98 tumor 10502319
ENSG00000110713 NUP98 AML 10556215
ENSG00000110713 NUP98 AML 10583265
ENSG00000110713 NUP98 AML 10700860
ENSG00000110713 NUP98 AML 10848835
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 10936866
ENSG00000110713 NUP98 AML 10959088
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 11157742
ENSG00000110713 NUP98 AML 11241795
ENSG00000110713 NUP98 AML 11681408
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 11737860
ENSG00000110713 NUP98 AML 11830496
ENSG00000110713 NUP98 AML 11895789
ENSG00000110713 NUP98 tumors 12032333
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 12112533
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 12543865
ENSG00000110713 NUP98 AML 12874791
ENSG00000110713 NUP98 AML 12970787
ENSG00000110713 NUP98 AML 15036893
ENSG00000110713 NUP98 tumors 15182531
ENSG00000110713 NUP98 AML-M2 15721637
ENSG00000110713 NUP98 tumors 16282337
ENSG00000110713 NUP98 AML-M0 16419055
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 16861351
ENSG00000110713 NUP98 tumor 16939812
ENSG00000110713 NUP98 thymic tumors 17429429
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 17442773
ENSG00000110713 NUP98 tumor 18223676
ENSG00000110713 NUP98 AML 18264136
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 18375036
ENSG00000110713 NUP98 Acute myeloid leukemia (AML) 19225539
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 19430464
ENSG00000110713 NUP98 AML M4 19665070
ENSG00000110713 NUP98 AML 21130494
ENSG00000110713 NUP98 AML 21467841
ENSG00000110713 NUP98 AML 21471525
ENSG00000110713 NUP98 AML 21810091
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 21813447
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 21867644
ENSG00000110713 NUP98 Tumor 22606303
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 22885519
ENSG00000110713 NUP98 pediatric AML 23531517
ENSG00000110713 NUP98 AML 23630019
ENSG00000110713 NUP98 AML 23847761
ENSG00000110713 NUP98 AMLs 23936658
ENSG00000110713 NUP98 tumors 24213499
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 24535671
ENSG00000110713 NUP98 cancers 24874471
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 25145343
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 25301331
ENSG00000110713 NUP98 AML 25487151
ENSG00000110713 NUP98 tumor 25741594
ENSG00000110713 NUP98 AML 26004809
ENSG00000110713 NUP98 AML 26071460
ENSG00000110713 NUP98 AML 26418229
ENSG00000110713 NUP98 AML 26684393
ENSG00000110713 NUP98 cancers 26731471
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 27031510
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 27060678
ENSG00000110713 NUP98 cancer 27144525
ENSG00000110713 NUP98 pediatric AML 27694926
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 27890253
ENSG00000110713 NUP98 AML 27890935
ENSG00000110713 NUP98 tumors 28117658
ENSG00000110713 NUP98 AML 28521413
ENSG00000110713 NUP98 pediatric AML 28710806
ENSG00000110713 NUP98 AML 28854430
ENSG00000110713 NUP98 AML 29034209
ENSG00000110713 NUP98 AMLs 29075615
ENSG00000110713 NUP98 AML 29326122
ENSG00000110713 NUP98 AML 29527516
ENSG00000110713 NUP98 cancers 30361777
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 30378313
ENSG00000110713 NUP98 Acute myeloid leukemia (AML) 30568173
ENSG00000110713 NUP98 AML 30700838
ENSG00000110713 NUP98 AML-M2 30848074
ENSG00000110713 NUP98 breast cancer 30935371
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 31134509
ENSG00000110713 NUP98 AML 31137568
ENSG00000110713 NUP98 cancer 31190890
ENSG00000110713 NUP98 AML 31207999
ENSG00000110713 NUP98 AML 31213012
ENSG00000110713 NUP98 AML 31467532
ENSG00000110713 NUP98 AML 31473470
ENSG00000110713 NUP98 AML 31681706
ENSG00000110713 NUP98 AML 31709264
ENSG00000110713 NUP98 acute myeloid leukemia (AML) 9858599
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000110713 NUP98 acute myeloid leukemia gene_fusion 8.725% (236/2705) 2 entries
ENSG00000110713 NUP98 breast ductal adenocarcinoma stop_gained 10.86% (67/617) 3 entries
ENSG00000110713 NUP98 breast ductal adenocarcinoma sequence_alteration 10.86% (67/617) 1 entry
ENSG00000110713 NUP98 breast ductal adenocarcinoma missense_variant 10.86% (67/617) 2 entries
ENSG00000110713 NUP98 pancreatic ductal adenocarcinoma missense_variant 3.892% (49/1259) 1 entry
ENSG00000110713 NUP98 colon adenocarcinoma missense_variant 2.727% (21/770) 4 entries
ENSG00000110713 NUP98 head and neck squamous cell carcinoma missense_variant 1.438% (9/626) 1 entry
ENSG00000110713 NUP98 prostate adenocarcinoma sequence_alteration 3.92% (57/1454) 1 entry
ENSG00000110713 NUP98 squamous cell lung carcinoma missense_variant 1.455% (12/825) 1 entry
ENSG00000110713 NUP98 hepatocellular carcinoma frameshift_variant 2.442% (22/901) 1 entry
ENSG00000110713 NUP98 female breast carcinoma sequence_alteration 1.79% (7/391) 1 entry
ENSG00000110713 NUP98 basal cell carcinoma sequence_alteration 8.621% (5/58) 1 entry
ENSG00000110713 NUP98 brain glioblastoma frameshift_variant 0.54% (5/926) 2 entries
ENSG00000110713 NUP98 clear cell renal carcinoma sequence_alteration 0.6531% (9/1378) 1 entry
ENSG00000110713 NUP98 breast carcinoma sequence_alteration 0.9213% (13/1411) 1 entry
ENSG00000110713 NUP98 hepatocellular carcinoma missense_variant 2.442% (22/901) 1 entry
ENSG00000110713 NUP98 prostate carcinoma missense_variant 3.099% (15/484) 1 entry
ENSG00000110713 NUP98 skin melanoma frameshift_variant 3.206% (31/967) 2 entries
ENSG00000110713 NUP98 colorectal adenocarcinoma sequence_alteration 4.306% (49/1138) 1 entry
ENSG00000110713 NUP98 bladder carcinoma missense_variant 3.243% (18/555) 1 entry
ENSG00000110713 NUP98 prostate adenocarcinoma missense_variant 3.92% (57/1454) 1 entry
ENSG00000110713 NUP98 colorectal adenocarcinoma missense_variant 4.306% (49/1138) 4 entries
ENSG00000110713 NUP98 oral squamous cell carcinoma missense_variant 0.9709% (2/206) 2 entries
ENSG00000110713 NUP98 female breast carcinoma missense_variant 1.79% (7/391) 1 entry
ENSG00000110713 NUP98 melanoma missense_variant 6.931% (7/101) 1 entry
ENSG00000110713 NUP98 esophageal squamous cell carcinoma missense_variant 1.185% (8/675) 4 entries
ENSG00000110713 NUP98 small cell lung carcinoma missense_variant 1.538% (5/325) 2 entries
ENSG00000110713 NUP98 esophageal adenocarcinoma missense_variant 6.621% (29/438) 1 entry
ENSG00000110713 NUP98 skin melanoma sequence_alteration 3.206% (31/967) 1 entry
ENSG00000110713 NUP98 basal cell carcinoma missense_variant 8.621% (5/58) 1 entry
ENSG00000110713 NUP98 lung adenocarcinoma missense_variant 1.639% (20/1220) 3 entries
ENSG00000110713 NUP98 colon adenocarcinoma frameshift_variant 2.727% (21/770) 2 entries
ENSG00000110713 NUP98 myelodysplastic syndrome missense_variant 3.272% (25/764) 3 entries
ENSG00000110713 NUP98 colon adenocarcinoma sequence_alteration 2.727% (21/770) 3 entries
ENSG00000110713 NUP98 melanoma sequence_alteration 6.931% (7/101) 2 entries
ENSG00000110713 NUP98 clear cell renal carcinoma missense_variant 0.6531% (9/1378) 2 entries
ENSG00000110713 NUP98 colorectal adenocarcinoma stop_gained 4.306% (49/1138) 2 entries
ENSG00000110713 NUP98 chronic myelomonocytic leukemia missense_variant 3.093% (3/97) 1 entry
ENSG00000110713 NUP98 squamous cell lung carcinoma sequence_alteration 1.455% (12/825) 1 entry
ENSG00000110713 NUP98 skin melanoma missense_variant 3.206% (31/967) 5 entries
ENSG00000110713 NUP98 breast carcinoma missense_variant 0.9213% (13/1411) 2 entries
ENSG00000110713 NUP98 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000110713 NUP98 prostate carcinoma sequence_alteration 3.099% (15/484) 1 entry
ENSG00000110713 NUP98 lung adenocarcinoma sequence_alteration 1.639% (20/1220) 1 entry
ENSG00000110713 NUP98 gastric adenocarcinoma missense_variant 3.387% (23/679) 2 entries
ENSG00000110713 NUP98 melanoma frameshift_variant 6.931% (7/101) 1 entry
ENSG00000110713 NUP98 chronic lymphocytic leukemia missense_variant 1.126% (10/888) 2 entries
ENSG00000110713 NUP98 bladder transitional cell carcinoma missense_variant 1.46% (2/137) 1 entry
ENSG00000110713 NUP98 angiosarcoma sequence_alteration 15.38% (2/13) 1 entry
ENSG00000110713 NUP98 angiosarcoma missense_variant 15.38% (2/13) 1 entry
ENSG00000110713 NUP98 small cell lung carcinoma stop_gained 1.538% (5/325) 1 entry
ENSG00000110713 NUP98 marginal zone B-cell lymphoma missense_variant 6.667% (1/15) 1 entry
ENSG00000110713 NUP98 bronchoalveolar adenocarcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000110713 NUP98 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000110713 NUP98 bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
ENSG00000110713 NUP98 HER2 Positive Breast Carcinoma missense_variant 5.063% (8/158) 1 entry
ENSG00000110713 NUP98 nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000110713 NUP98 myelodysplastic syndrome frameshift_variant 3.272% (25/764) 1 entry
ENSG00000110713 NUP98 brain glioblastoma sequence_alteration 0.54% (5/926) 1 entry
ENSG00000110713 NUP98 bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000110713 NUP98 prostate carcinoma frameshift_variant 3.099% (15/484) 1 entry
ENSG00000110713 NUP98 adrenal cortex carcinoma sequence_alteration 0.6098% (1/164) 1 entry
ENSG00000110713 NUP98 squamous cell lung carcinoma stop_gained 1.455% (12/825) 1 entry
ENSG00000110713 NUP98 ovarian clear cell adenocarcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000110713 NUP98 colon adenocarcinoma stop_gained 2.727% (21/770) 1 entry
ENSG00000110713 NUP98 primary peritoneal carcinoma (disease) frameshift_variant 100.0% (1/1) 1 entry
ENSG00000110713 NUP98 alveolar rhabdomyosarcoma missense_variant 1.695% (1/59) 1 entry
ENSG00000110713 NUP98 bladder transitional cell carcinoma sequence_alteration 1.46% (2/137) 1 entry
ENSG00000110713 NUP98 nasopharyngeal squamous cell carcinoma stop_gained 1.198% (2/167) 1 entry
ENSG00000110713 NUP98 lung adenocarcinoma stop_gained 1.639% (20/1220) 1 entry
ENSG00000110713 NUP98 colorectal adenocarcinoma frameshift_variant 4.306% (49/1138) 1 entry
ENSG00000110713 NUP98 Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000110713 NUP98 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000110713 NUP98 pulmonary blastoma missense_variant 4.167% (1/24) 1 entry
ENSG00000110713 NUP98 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000110713 NUP98 Mantle cell lymphoma frameshift_variant 2.439% (1/41) 1 entry
ENSG00000110713 NUP98 myelodysplastic syndrome conservative_inframe_deletion 3.272% (25/764) 1 entry
ENSG00000110713 NUP98 colorectal adenocarcinoma conservative_inframe_deletion 4.306% (49/1138) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000110713 NUP98 MESO 0.0031 high
ENSG00000110713 NUP98 SARC 0.05 high
ENSG00000110713 NUP98 UVM 0.0076 high
ENSG00000110713 NUP98 PAAD 0.01 high
ENSG00000110713 NUP98 ACC 0.00029 high
ENSG00000110713 NUP98 LUSC 0.0071 high
ENSG00000110713 NUP98 READ 0.008 low
ENSG00000110713 NUP98 KIRP 0.0022 high
ENSG00000110713 NUP98 KICH 0.00013 high
ENSG00000110713 NUP98 PCPG 0.023 high
ENSG00000110713 NUP98 ESCA 0.05 low
ENSG00000110713 NUP98 OV 0.012 high
ENSG00000110713 NUP98 PRAD 0.037 high
ENSG00000110713 NUP98 LAML 0.015 low
ENSG00000110713 NUP98 GBM 0.0034 high
ENSG00000110713 NUP98 SKCM 0.0034 low
ENSG00000110713 NUP98 LIHC 0.0023 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000110713 NUP98 LUSC Del 10.608143 0.154078 0.372456 0.479042
ENSG00000110713 NUP98 LUAD Del 1.367546 0.060217 0.296792 0.257752
ENSG00000110713 NUP98 LGG Del 9.286342 0.100456 0.570421 0.198830
ENSG00000110713 NUP98 SARC Del 1.355587 0.140702 0.510419 0.396887
ENSG00000110713 NUP98 GBM Del 1.353383 0.060231 0.484522 0.207972
ENSG00000110713 NUP98 PAAD Del 1.641919 0.064724 0.336912 0.152174
ENSG00000110713 NUP98 ESCA Del 0.820833 0.100616 0.362581 0.407609
ENSG00000110713 NUP98 HNSC Del 2.809139 0.075703 0.366627 0.312261
ENSG00000110713 NUP98 PCPG Del 1.688309 0.078860 0.626959 0.358025
ENSG00000110713 NUP98 BLCA Del 2.197427 0.101100 0.434266 0.531863
ENSG00000110713 NUP98 BRCA Del 10.916594 0.118290 0.432397 0.275926
ENSG00000110713 NUP98 STAD Del 0.677750 0.060147 0.349512 0.213152
ENSG00000110713 NUP98 UCEC Del 2.842297 0.071105 0.521210 0.187384
ENSG00000110713 NUP98 OV Del 31.515381 0.459799 0.604409 0.590674