Ensembl ID ENSG00000110619 Gene ID 833 Accession 1493
Gene Symbol CARS1 Alias CARS;MDBH;CYSRS;MCDDBH;MGC:11246 Full Name cysteinyl-tRNA synthetase 1
Position 11 : 3000922 - 3057613 Length 56692 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

ENSG00000110619 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000110619 CARS1 0.76 1.77e-50 KIRC
ENSG00000110619 CARS1 0.35 7.66e-15 BRCA
ENSG00000110619 CARS1 1.18 6.18e-28 KICH
ENSG00000110619 CARS1 0.55 5.55e-16 LUSC
ENSG00000110619 CARS1 0.66 1.79e-15 UCEC
ENSG00000110619 CARS1 0.48 5.95e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000110619 CARS1 colorectal adenocarcinoma sequence_alteration 3.427% (39/1138) 2 entries
ENSG00000110619 CARS1 Merkel cell skin cancer sequence_alteration 16.67% (5/30) 1 entry
ENSG00000110619 CARS1 colorectal adenocarcinoma stop_gained 3.427% (39/1138) 1 entry
ENSG00000110619 CARS1 colorectal adenocarcinoma missense_variant 3.427% (39/1138) 3 entries
ENSG00000110619 CARS1 inflammatory myofibroblastic tumor gene_fusion 50.0% (3/6) 2 entries
ENSG00000110619 CARS1 clear cell renal carcinoma sequence_alteration 0.3628% (5/1378) 2 entries
ENSG00000110619 CARS1 skin melanoma missense_variant 1.342% (13/969) 4 entries
ENSG00000110619 CARS1 colon adenocarcinoma missense_variant 2.493% (18/722) 5 entries
ENSG00000110619 CARS1 non-small cell lung carcinoma missense_variant 3.226% (2/62) 1 entry
ENSG00000110619 CARS1 lung adenocarcinoma missense_variant 0.6557% (8/1220) 2 entries
ENSG00000110619 CARS1 prostate carcinoma sequence_alteration 0.8264% (4/484) 1 entry
ENSG00000110619 CARS1 Merkel cell skin cancer missense_variant 16.67% (5/30) 1 entry
ENSG00000110619 CARS1 gastric adenocarcinoma missense_variant 0.7168% (4/558) 1 entry
ENSG00000110619 CARS1 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000110619 CARS1 melanoma sequence_alteration 2.97% (3/101) 1 entry
ENSG00000110619 CARS1 clear cell renal carcinoma missense_variant 0.3628% (5/1378) 1 entry
ENSG00000110619 CARS1 colon adenocarcinoma sequence_alteration 2.493% (18/722) 1 entry
ENSG00000110619 CARS1 breast carcinoma missense_variant 0.567% (8/1411) 1 entry
ENSG00000110619 CARS1 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 2 entries
ENSG00000110619 CARS1 colon adenocarcinoma frameshift_variant 2.493% (18/722) 2 entries
ENSG00000110619 CARS1 oral squamous cell carcinoma missense_variant 0.9709% (2/206) 2 entries
ENSG00000110619 CARS1 squamous cell lung carcinoma missense_variant 1.455% (12/825) 1 entry
ENSG00000110619 CARS1 breast ductal adenocarcinoma missense_variant 3.767% (22/584) 1 entry
ENSG00000110619 CARS1 nasopharyngeal squamous cell carcinoma missense_variant 1.796% (3/167) 1 entry
ENSG00000110619 CARS1 basal cell carcinoma missense_variant 3.448% (2/58) 1 entry
ENSG00000110619 CARS1 esophageal adenocarcinoma sequence_alteration 3.196% (14/438) 1 entry
ENSG00000110619 CARS1 central nervous system primitive neuroectodermal neoplasm sequence_alteration 0.6757% (3/444) 1 entry
ENSG00000110619 CARS1 esophageal squamous cell carcinoma missense_variant 0.4444% (3/675) 3 entries
ENSG00000110619 CARS1 nasopharyngeal squamous cell carcinoma sequence_alteration 1.796% (3/167) 1 entry
ENSG00000110619 CARS1 multiple myeloma sequence_alteration 2.273% (1/44) 1 entry
ENSG00000110619 CARS1 skin carcinoma missense_variant 2.885% (3/104) 1 entry
ENSG00000110619 CARS1 papillary renal cell carcinoma missense_variant 0.2985% (1/335) 1 entry
ENSG00000110619 CARS1 basal cell carcinoma sequence_alteration 3.448% (2/58) 1 entry
ENSG00000110619 CARS1 colon adenocarcinoma conservative_inframe_deletion 2.493% (18/722) 1 entry
ENSG00000110619 CARS1 brain glioblastoma sequence_alteration 0.108% (1/926) 1 entry
ENSG00000110619 CARS1 Malignant Adrenal Gland Pheochromocytoma sequence_alteration 16.67% (1/6) 1 entry
ENSG00000110619 CARS1 Liver Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (1/2) 1 entry
ENSG00000110619 CARS1 gastric adenocarcinoma frameshift_variant 0.7168% (4/558) 1 entry
ENSG00000110619 CARS1 melanoma missense_variant 2.97% (3/101) 1 entry
ENSG00000110619 CARS1 melanoma stop_gained 2.97% (3/101) 1 entry
ENSG00000110619 CARS1 central nervous system primitive neuroectodermal neoplasm missense_variant 0.6757% (3/444) 1 entry
ENSG00000110619 CARS1 pancreatic ductal adenocarcinoma missense_variant 1.668% (21/1259) 1 entry
ENSG00000110619 CARS1 Pleural Epithelioid Mesothelioma sequence_alteration 1.064% (1/94) 1 entry
ENSG00000110619 CARS1 lung adenocarcinoma stop_gained 0.6557% (8/1220) 1 entry
ENSG00000110619 CARS1 gastric intestinal type adenocarcinoma sequence_alteration 2.353% (2/85) 1 entry
ENSG00000110619 CARS1 medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000110619 CARS1 colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000110619 CARS1 Ampulla of Vater Carcinoma sequence_alteration 1.176% (1/85) 1 entry
ENSG00000110619 CARS1 chronic lymphocytic leukemia missense_variant 0.3378% (3/888) 1 entry
ENSG00000110619 CARS1 Pleural Epithelioid Mesothelioma missense_variant 1.064% (1/94) 1 entry
ENSG00000110619 CARS1 bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
ENSG00000110619 CARS1 Malignant Adrenal Gland Pheochromocytoma missense_variant 16.67% (1/6) 1 entry
ENSG00000110619 CARS1 lung adenocarcinoma sequence_alteration 0.6557% (8/1220) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000110619 CARS1 MESO 0.00072 high
ENSG00000110619 CARS1 STAD 0.023 low
ENSG00000110619 CARS1 UVM 0.048 high
ENSG00000110619 CARS1 PAAD 0.024 high
ENSG00000110619 CARS1 ACC 0.00023 high
ENSG00000110619 CARS1 LGG 0.01 high
ENSG00000110619 CARS1 LUSC 0.03 high
ENSG00000110619 CARS1 HNSC 0.038 high
ENSG00000110619 CARS1 READ 0.046 low
ENSG00000110619 CARS1 KICH 0.00024 high
ENSG00000110619 CARS1 LUAD 0.014 high
ENSG00000110619 CARS1 PCPG 0.0018 high
ENSG00000110619 CARS1 BRCA 0.038 high
ENSG00000110619 CARS1 ESCA 0.013 high
ENSG00000110619 CARS1 DLBC 0.025 low
ENSG00000110619 CARS1 GBM 0.0085 high
ENSG00000110619 CARS1 SKCM 0.008 low
ENSG00000110619 CARS1 LIHC 0.00017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000110619 CARS1 LUSC Del 11.779928 0.161641 0.375452 0.485030
ENSG00000110619 CARS1 LUAD Del 1.883370 0.066092 0.300146 0.265504
ENSG00000110619 CARS1 LGG Del 9.463583 0.101512 0.575321 0.202729
ENSG00000110619 CARS1 CESC Del 0.881930 0.070831 0.483656 0.352542
ENSG00000110619 CARS1 SARC Del 1.402183 0.142387 0.508814 0.392996
ENSG00000110619 CARS1 GBM Del 1.315174 0.059855 0.477153 0.213172
ENSG00000110619 CARS1 PAAD Del 1.428142 0.060016 0.341808 0.157609
ENSG00000110619 CARS1 ESCA Del 2.584295 0.148276 0.382809 0.429348
ENSG00000110619 CARS1 HNSC Del 2.208815 0.070310 0.365820 0.312261
ENSG00000110619 CARS1 PCPG Del 1.514672 0.075518 0.627179 0.358025
ENSG00000110619 CARS1 BLCA Del 2.442122 0.104550 0.435734 0.534314
ENSG00000110619 CARS1 BRCA Del 12.910327 0.125507 0.434109 0.282407
ENSG00000110619 CARS1 STAD Del 2.266330 0.081751 0.376174 0.219955
ENSG00000110619 CARS1 UCEC Del 3.526581 0.077131 0.525215 0.191095
ENSG00000110619 CARS1 OV Del 34.149739 0.475880 0.609774 0.594128