Ensembl ID ENSG00000109971 Gene ID 3312 Accession 5241
Gene Symbol HSPA8 Alias LAP1;HSC54;HSC70;HSC71;HSP71;HSP73;LAP-1;NIP71;HEL-33;HSPA10;HEL-S-72p Full Name heat shock protein family A (Hsp70) member 8
Position 11 : 123057489 - 123063230 Length 5742 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

ENSG00000109971 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000109971 HSPA8 -0.6 7.95e-17 KIRC
ENSG00000109971 HSPA8 0.45 1.20e-12 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000109971 HSPA8 cancers 10485459
ENSG00000109971 HSPA8 cancer 10892905
ENSG00000109971 HSPA8 laryngeal cancer 10920983
ENSG00000109971 HSPA8 tumours 11205288
ENSG00000109971 HSPA8 cancer 11244940
ENSG00000109971 HSPA8 breast cancer 12081204
ENSG00000109971 HSPA8 tumors 12826079
ENSG00000109971 HSPA8 cancer 12966429
ENSG00000109971 HSPA8 cancer 14978028
ENSG00000109971 HSPA8 Tumors 14991745
ENSG00000109971 HSPA8 colon cancer 15156568
ENSG00000109971 HSPA8 tumour 15254721
ENSG00000109971 HSPA8 tumor 15598346
ENSG00000109971 HSPA8 ovarian cancer 16036111
ENSG00000109971 HSPA8 colorectal cancer 16043893
ENSG00000109971 HSPA8 tumor 18772114
ENSG00000109971 HSPA8 cancer 19197160
ENSG00000109971 HSPA8 breast cancer 19800331
ENSG00000109971 HSPA8 cancer 20023747
ENSG00000109971 HSPA8 tumor 20616019
ENSG00000109971 HSPA8 tumor 20617406
ENSG00000109971 HSPA8 cancers 21137014
ENSG00000109971 HSPA8 cancer 21892295
ENSG00000109971 HSPA8 cancer 22917186
ENSG00000109971 HSPA8 cancer 22960394
ENSG00000109971 HSPA8 breast cancer 23065205
ENSG00000109971 HSPA8 cancer 23090015
ENSG00000109971 HSPA8 tumor 23414419
ENSG00000109971 HSPA8 cancers 23875172
ENSG00000109971 HSPA8 breast cancer 24265689
ENSG00000109971 HSPA8 tumor 24477641
ENSG00000109971 HSPA8 prostate cancer 24606454
ENSG00000109971 HSPA8 tumor 24609033
ENSG00000109971 HSPA8 tumor 24694787
ENSG00000109971 HSPA8 tumor 24736948
ENSG00000109971 HSPA8 ovarian tumor 25286318
ENSG00000109971 HSPA8 tumors 25699276
ENSG00000109971 HSPA8 cancer 25779464
ENSG00000109971 HSPA8 tumour 25798051
ENSG00000109971 HSPA8 tumor 26122656
ENSG00000109971 HSPA8 cancer 26188124
ENSG00000109971 HSPA8 cancer 26549849
ENSG00000109971 HSPA8 cancer-associated retinopathy 26717306
ENSG00000109971 HSPA8 tumor 26885609
ENSG00000109971 HSPA8 cancers 27110132
ENSG00000109971 HSPA8 breast cancer 27506314
ENSG00000109971 HSPA8 cancer 27596272
ENSG00000109971 HSPA8 cancers 27793055
ENSG00000109971 HSPA8 cancer 27936075
ENSG00000109971 HSPA8 cancer 27939888
ENSG00000109971 HSPA8 tumor 28383167
ENSG00000109971 HSPA8 cancer 28542269
ENSG00000109971 HSPA8 cancer 28934328
ENSG00000109971 HSPA8 cancer 29137250
ENSG00000109971 HSPA8 ovarian cancer 29344361
ENSG00000109971 HSPA8 tumors 29507682
ENSG00000109971 HSPA8 cancers 29510992
ENSG00000109971 HSPA8 pancreatic cancer 29516568
ENSG00000109971 HSPA8 prostate cancer 29540470
ENSG00000109971 HSPA8 tumor 29868251
ENSG00000109971 HSPA8 tumor 29872313
ENSG00000109971 HSPA8 breast cancer 30279141
ENSG00000109971 HSPA8 cancer 30821613
ENSG00000109971 HSPA8 colon cancer 31095579
ENSG00000109971 HSPA8 cancer 31096896
ENSG00000109971 HSPA8 tumors 31205025
ENSG00000109971 HSPA8 cancer 31276277
ENSG00000109971 HSPA8 cancer 31394830
ENSG00000109971 HSPA8 tumors 31584998
ENSG00000109971 HSPA8 cancer 31591429
ENSG00000109971 HSPA8 tumor 7705958
ENSG00000109971 HSPA8 tumors 7803705
ENSG00000109971 HSPA8 brain tumor 8126080
ENSG00000109971 HSPA8 tumors 8900930
ENSG00000109971 HSPA8 brain tumor 9695029
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000109971 HSPA8 MESO 0.011 high
ENSG00000109971 HSPA8 SARC 0.039 high
ENSG00000109971 HSPA8 STAD 0.015 low
ENSG00000109971 HSPA8 ACC 0.037 high
ENSG00000109971 HSPA8 HNSC 0.047 high
ENSG00000109971 HSPA8 READ 0.0011 low
ENSG00000109971 HSPA8 KICH 0.0026 high
ENSG00000109971 HSPA8 LUAD 0.039 high
ENSG00000109971 HSPA8 PCPG 0.042 low
ENSG00000109971 HSPA8 THYM 0.011 low
ENSG00000109971 HSPA8 COAD 0.0032 low
ENSG00000109971 HSPA8 UCS 0.0046 low
ENSG00000109971 HSPA8 LAML 0.014 high
ENSG00000109971 HSPA8 GBM 0.028 low
ENSG00000109971 HSPA8 CESC 0.0032 high
ENSG00000109971 HSPA8 LIHC 0.00019 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000109971 HSPA8 LUSC Del 3.634419 0.100485 0.353714 0.349301
ENSG00000109971 HSPA8 LUAD Del 4.978888 0.092948 0.342171 0.234496
ENSG00000109971 HSPA8 LGG Amp 2.097083 0.064309 0.470841 0.165692
ENSG00000109971 HSPA8 CESC Del 29.107406 0.314886 0.579222 0.545763
ENSG00000109971 HSPA8 KIRP Del 3.401020 0.051877 0.573259 0.100694
ENSG00000109971 HSPA8 SARC Del 7.799685 0.262027 0.560625 0.470817
ENSG00000109971 HSPA8 ESCA Del 1.870578 0.129447 0.434119 0.429348
ENSG00000109971 HSPA8 SKCM Del 21.644928 0.249570 0.550954 0.539510
ENSG00000109971 HSPA8 HNSC Del 13.944083 0.142279 0.436418 0.455939
ENSG00000109971 HSPA8 LIHC Del 3.021393 0.098902 0.488372 0.256757
ENSG00000109971 HSPA8 TGCT Del 10.441968 0.217974 0.497308 0.813333
ENSG00000109971 HSPA8 BLCA Del 2.023791 0.098712 0.401249 0.370098
ENSG00000109971 HSPA8 BRCA Del 48.802673 0.223647 0.529862 0.487963
ENSG00000109971 HSPA8 STAD Del 2.182021 0.080769 0.365843 0.213152
ENSG00000109971 HSPA8 UCEC Del 2.994654 0.072511 0.535337 0.161410
ENSG00000109971 HSPA8 UVM Del 1.628635 0.100145 0.584322 0.087500
ENSG00000109971 HSPA8 OV Del 0.881364 0.178759 0.527521 0.326425