Ensembl ID ENSG00000109906 Gene ID 7704 Accession 12930
Gene Symbol ZBTB16 Alias PLZF;ZNF145 Full Name zinc finger and BTB domain containing 16
Position 11 : 114059041 - 114256765 Length 197725 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

ENSG00000109906 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000109906 ZBTB16 -3.7 2.48e-32 HNSC
ENSG00000109906 ZBTB16 -3.7 6.84e-14 BLCA
ENSG00000109906 ZBTB16 -3.0 1.14e-49 BRCA
ENSG00000109906 ZBTB16 -3.2 1.10e-19 COAD
ENSG00000109906 ZBTB16 -4.2 9.72e-50 LUSC
ENSG00000109906 ZBTB16 -2.8 2.79e-15 STAD
ENSG00000109906 ZBTB16 -4.4 1.85e-33 UCEC
ENSG00000109906 ZBTB16 -2.1 3.82e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000109906 ZBTB16 tumor 10980608
ENSG00000109906 ZBTB16 AML 11090081
ENSG00000109906 ZBTB16 tumor 11287007
ENSG00000109906 ZBTB16 tumor 12032783
ENSG00000109906 ZBTB16 cancer 12188922
ENSG00000109906 ZBTB16 Acute myeloid leukemia (AML) 12460926
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 14551142
ENSG00000109906 ZBTB16 cancer 14976551
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 15024077
ENSG00000109906 ZBTB16 prostate cancer 15065091
ENSG00000109906 ZBTB16 Cancer 15077196
ENSG00000109906 ZBTB16 prostate cancer 15334066
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 15516979
ENSG00000109906 ZBTB16 cancer 15542853
ENSG00000109906 ZBTB16 breast cancer 15647773
ENSG00000109906 ZBTB16 AMLs 16158049
ENSG00000109906 ZBTB16 prostate cancer 16637071
ENSG00000109906 ZBTB16 tumour 16720711
ENSG00000109906 ZBTB16 cervical cancer 16828757
ENSG00000109906 ZBTB16 tumor 16862184
ENSG00000109906 ZBTB16 cancer 16996269
ENSG00000109906 ZBTB16 tumor 17218380
ENSG00000109906 ZBTB16 ovarian cancer 17340613
ENSG00000109906 ZBTB16 cancer 17360752
ENSG00000109906 ZBTB16 cancers 17484138
ENSG00000109906 ZBTB16 cancer 17537403
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 18000064
ENSG00000109906 ZBTB16 cancer 18246121
ENSG00000109906 ZBTB16 tumor 18771349
ENSG00000109906 ZBTB16 tumor 19459408
ENSG00000109906 ZBTB16 tumour 19885562
ENSG00000109906 ZBTB16 tumor 20010871
ENSG00000109906 ZBTB16 germ-cell tumours 20147518
ENSG00000109906 ZBTB16 tumor 20634973
ENSG00000109906 ZBTB16 colorectal cancer 20945532
ENSG00000109906 ZBTB16 tumor 21293049
ENSG00000109906 ZBTB16 tumor 21311223
ENSG00000109906 ZBTB16 colorectal cancers 21710690
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 21811629
ENSG00000109906 ZBTB16 cancer 21915328
ENSG00000109906 ZBTB16 tumor 22555178
ENSG00000109906 ZBTB16 cancer 22822476
ENSG00000109906 ZBTB16 colorectal cancer 23280881
ENSG00000109906 ZBTB16 colon cancer 23451083
ENSG00000109906 ZBTB16 tumor 23733752
ENSG00000109906 ZBTB16 non-small-cell lung cancers 23804241
ENSG00000109906 ZBTB16 cancer 23889843
ENSG00000109906 ZBTB16 tumors 24115909
ENSG00000109906 ZBTB16 tumors 24339862
ENSG00000109906 ZBTB16 Colorectal Cancer 24348178
ENSG00000109906 ZBTB16 tumour 24619130
ENSG00000109906 ZBTB16 smooth muscle tumors 24784718
ENSG00000109906 ZBTB16 tumors 24821727
ENSG00000109906 ZBTB16 tumor 24821728
ENSG00000109906 ZBTB16 tumour 24990570
ENSG00000109906 ZBTB16 granulosa cell tumors 25023763
ENSG00000109906 ZBTB16 colon cancer 25369784
ENSG00000109906 ZBTB16 cancer 25705792
ENSG00000109906 ZBTB16 Tumor 25807461
ENSG00000109906 ZBTB16 tumor 25808865
ENSG00000109906 ZBTB16 cancer 25990457
ENSG00000109906 ZBTB16 AML 26205084
ENSG00000109906 ZBTB16 tumor 26297253
ENSG00000109906 ZBTB16 GBM 26424050
ENSG00000109906 ZBTB16 tumor 26916077
ENSG00000109906 ZBTB16 GBM 27225222
ENSG00000109906 ZBTB16 prostate cancer 27541592
ENSG00000109906 ZBTB16 prostate cancer 27557496
ENSG00000109906 ZBTB16 tumor 28038473
ENSG00000109906 ZBTB16 tumor 28071754
ENSG00000109906 ZBTB16 ovarian cancer 28396661
ENSG00000109906 ZBTB16 Cancer 28428441
ENSG00000109906 ZBTB16 tumour 28581124
ENSG00000109906 ZBTB16 liver cancer 28740751
ENSG00000109906 ZBTB16 prostate cancer 29050363
ENSG00000109906 ZBTB16 Cancer 29317492
ENSG00000109906 ZBTB16 tumor 29358655
ENSG00000109906 ZBTB16 tumor 29375569
ENSG00000109906 ZBTB16 tumor 29439675
ENSG00000109906 ZBTB16 Breast Cancer 29518903
ENSG00000109906 ZBTB16 cancer 30214553
ENSG00000109906 ZBTB16 gastric cancer 30431129
ENSG00000109906 ZBTB16 Tumor 30602500
ENSG00000109906 ZBTB16 tumor 30818388
ENSG00000109906 ZBTB16 pancreatic cancer 31087222
ENSG00000109906 ZBTB16 prostate cancer 31142324
ENSG00000109906 ZBTB16 primitive neuroectodermal tumor 31326195
ENSG00000109906 ZBTB16 prostate cancers 31366128
ENSG00000109906 ZBTB16 acute myeloid leukemia (AML) 31378879
ENSG00000109906 ZBTB16 tumor 31444154
ENSG00000109906 ZBTB16 prostate cancer 31496751
ENSG00000109906 ZBTB16 AML-M2 8387545
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000109906 ZBTB16 breast ductal adenocarcinoma sequence_alteration 14.55% (85/584) 1 entry
ENSG00000109906 ZBTB16 esophageal adenocarcinoma missense_variant 16.89% (74/438) 2 entries
ENSG00000109906 ZBTB16 central nervous system primitive neuroectodermal neoplasm sequence_alteration 1.577% (7/444) 1 entry
ENSG00000109906 ZBTB16 basal cell carcinoma missense_variant 6.897% (4/58) 1 entry
ENSG00000109906 ZBTB16 skin melanoma missense_variant 3.309% (32/967) 3 entries
ENSG00000109906 ZBTB16 skin melanoma stop_gained 3.309% (32/967) 1 entry
ENSG00000109906 ZBTB16 prostate carcinoma missense_variant 4.339% (21/484) 2 entries
ENSG00000109906 ZBTB16 rectal adenocarcinoma missense_variant 3.62% (8/221) 1 entry
ENSG00000109906 ZBTB16 squamous cell lung carcinoma missense_variant 1.212% (10/825) 3 entries
ENSG00000109906 ZBTB16 Mantle cell lymphoma sequence_alteration 7.317% (3/41) 1 entry
ENSG00000109906 ZBTB16 melanoma missense_variant 3.96% (4/101) 3 entries
ENSG00000109906 ZBTB16 cecum adenocarcinoma frameshift_variant 9.6% (12/125) 1 entry
ENSG00000109906 ZBTB16 colorectal adenocarcinoma missense_variant 3.163% (36/1138) 2 entries
ENSG00000109906 ZBTB16 hairy cell leukemia missense_variant 14.29% (3/21) 2 entries
ENSG00000109906 ZBTB16 cecum adenocarcinoma missense_variant 9.6% (12/125) 2 entries
ENSG00000109906 ZBTB16 rectal adenocarcinoma stop_gained 3.62% (8/221) 1 entry
ENSG00000109906 ZBTB16 cecum adenocarcinoma sequence_alteration 9.6% (12/125) 1 entry
ENSG00000109906 ZBTB16 rectal adenocarcinoma sequence_alteration 3.62% (8/221) 1 entry
ENSG00000109906 ZBTB16 oral squamous cell carcinoma missense_variant 0.9756% (2/205) 2 entries
ENSG00000109906 ZBTB16 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000109906 ZBTB16 colon adenocarcinoma sequence_alteration 5.125% (37/722) 1 entry
ENSG00000109906 ZBTB16 clear cell renal carcinoma missense_variant 0.1451% (2/1378) 1 entry
ENSG00000109906 ZBTB16 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 2 entries
ENSG00000109906 ZBTB16 prostate carcinoma sequence_alteration 4.339% (21/484) 2 entries
ENSG00000109906 ZBTB16 colorectal adenocarcinoma sequence_alteration 3.163% (36/1138) 2 entries
ENSG00000109906 ZBTB16 esophageal squamous cell carcinoma missense_variant 0.7407% (5/675) 3 entries
ENSG00000109906 ZBTB16 hemangioblastoma sequence_alteration 6.25% (2/32) 1 entry
ENSG00000109906 ZBTB16 Merkel cell skin cancer missense_variant 6.667% (2/30) 1 entry
ENSG00000109906 ZBTB16 hepatocellular carcinoma missense_variant 1.11% (10/901) 1 entry
ENSG00000109906 ZBTB16 lung adenocarcinoma missense_variant 1.311% (16/1220) 3 entries
ENSG00000109906 ZBTB16 nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 2 entries
ENSG00000109906 ZBTB16 colon adenocarcinoma missense_variant 5.125% (37/722) 4 entries
ENSG00000109906 ZBTB16 T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000109906 ZBTB16 brain glioblastoma frameshift_variant 0.216% (2/926) 1 entry
ENSG00000109906 ZBTB16 salivary gland adenoid cystic carcinoma missense_variant 1.961% (1/51) 1 entry
ENSG00000109906 ZBTB16 colorectal adenocarcinoma frameshift_variant 3.163% (36/1138) 1 entry
ENSG00000109906 ZBTB16 gastric intestinal type adenocarcinoma stop_gained 3.529% (3/85) 1 entry
ENSG00000109906 ZBTB16 Endometrial Clear Cell Adenocarcinoma sequence_alteration 8.333% (1/12) 1 entry
ENSG00000109906 ZBTB16 small cell lung carcinoma sequence_alteration 0.6192% (2/323) 1 entry
ENSG00000109906 ZBTB16 colorectal adenoma missense_variant 11.11% (1/9) 1 entry
ENSG00000109906 ZBTB16 bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000109906 ZBTB16 basal cell carcinoma sequence_alteration 6.897% (4/58) 1 entry
ENSG00000109906 ZBTB16 brain glioblastoma missense_variant 0.216% (2/926) 1 entry
ENSG00000109906 ZBTB16 prostate carcinoma frameshift_variant 4.339% (21/484) 1 entry
ENSG00000109906 ZBTB16 lung adenocarcinoma frameshift_variant 1.311% (16/1220) 1 entry
ENSG00000109906 ZBTB16 prostate carcinoma stop_gained 4.339% (21/484) 1 entry
ENSG00000109906 ZBTB16 bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000109906 ZBTB16 medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000109906 ZBTB16 diffuse gastric adenocarcinoma missense_variant 1.266% (1/79) 1 entry
ENSG00000109906 ZBTB16 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000109906 ZBTB16 small cell lung carcinoma missense_variant 0.6192% (2/323) 1 entry
ENSG00000109906 ZBTB16 Gallbladder Adenocarcinoma stop_gained 1.149% (1/87) 1 entry
ENSG00000109906 ZBTB16 multiple myeloma missense_variant 2.273% (1/44) 1 entry
ENSG00000109906 ZBTB16 diffuse large B-cell lymphoma missense_variant 0.6601% (2/303) 1 entry
ENSG00000109906 ZBTB16 skin melanoma sequence_alteration 3.309% (32/967) 1 entry
ENSG00000109906 ZBTB16 ependymoma sequence_alteration 2.174% (1/46) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000109906 ZBTB16 STAD 0.0046 high
ENSG00000109906 ZBTB16 CHOL 0.031 high
ENSG00000109906 ZBTB16 ACC 0.00011 low
ENSG00000109906 ZBTB16 LGG 0.00024 low
ENSG00000109906 ZBTB16 LUSC 0.0038 high
ENSG00000109906 ZBTB16 READ 0.047 high
ENSG00000109906 ZBTB16 KIRP 0.00031 low
ENSG00000109906 ZBTB16 KICH 0.0098 low
ENSG00000109906 ZBTB16 LUAD 0.035 low
ENSG00000109906 ZBTB16 THYM 4e-04 high
ENSG00000109906 ZBTB16 OV 0.00067 high
ENSG00000109906 ZBTB16 BLCA 0.016 high
ENSG00000109906 ZBTB16 LAML 0.0064 low
ENSG00000109906 ZBTB16 SKCM 0.027 low
ENSG00000109906 ZBTB16 LIHC 0.022 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000109906 ZBTB16 LUSC Del 2.519810 0.089032 0.344876 0.353293
ENSG00000109906 ZBTB16 LUAD Del 5.360741 0.095886 0.353761 0.234496
ENSG00000109906 ZBTB16 CESC Del 26.848334 0.299839 0.575628 0.538983
ENSG00000109906 ZBTB16 KIRP Del 4.900131 0.064282 0.594938 0.107639
ENSG00000109906 ZBTB16 SARC Del 6.556432 0.242227 0.541149 0.474708
ENSG00000109906 ZBTB16 ESCA Del 1.870578 0.129447 0.446207 0.413043
ENSG00000109906 ZBTB16 SKCM Del 25.346145 0.277005 0.558900 0.553134
ENSG00000109906 ZBTB16 HNSC Del 18.021473 0.162397 0.438820 0.478927
ENSG00000109906 ZBTB16 LIHC Del 2.550994 0.093049 0.485259 0.251351
ENSG00000109906 ZBTB16 PCPG Del 0.820236 0.060816 0.624837 0.277778
ENSG00000109906 ZBTB16 TGCT Del 4.899075 0.138579 0.476014 0.806667
ENSG00000109906 ZBTB16 BLCA Del 2.692965 0.107734 0.400586 0.387255
ENSG00000109906 ZBTB16 BRCA Del 56.701635 0.242794 0.527069 0.512963
ENSG00000109906 ZBTB16 STAD Del 4.077100 0.100164 0.377031 0.224490
ENSG00000109906 ZBTB16 PRAD Del 6.826638 0.128510 0.594181 0.103659
ENSG00000109906 ZBTB16 UCEC Del 2.398240 0.067088 0.536119 0.159555
ENSG00000109906 ZBTB16 MESO Del 1.955199 0.175464 0.538158 0.206897
ENSG00000109906 ZBTB16 OV Del 0.621854 0.171653 0.527044 0.309154