Ensembl ID ENSG00000109814 Gene ID 7358 Accession 12525
Gene Symbol UGDH Alias GDH;UGD;DEE84;EIEE84;UDPGDH;UDP-GlcDH Full Name UDP-glucose 6-dehydrogenase
Position 4 : 39498755 - 39528311 Length 29557 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

ENSG00000109814 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000109814 UGDH 0.89 1.09e-15 BRCA
ENSG00000109814 UGDH -1.8 2.49e-63 COAD
ENSG00000109814 UGDH -1.7 1.21e-16 READ
ENSG00000109814 UGDH 1.48 3.99e-20 LUSC
ENSG00000109814 UGDH 1.88 1.93e-27 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000109814 UGDH breast cancer 10499502
ENSG00000109814 UGDH breast cancer 16158268
ENSG00000109814 UGDH breast cancer 18930055
ENSG00000109814 UGDH tumor 19244115
ENSG00000109814 UGDH breast cancer 19638449
ENSG00000109814 UGDH tumor 19676054
ENSG00000109814 UGDH cancers 21984906
ENSG00000109814 UGDH tumor 25974208
ENSG00000109814 UGDH tumor 26903444
ENSG00000109814 UGDH tumor 27307252
ENSG00000109814 UGDH tumor 27470985
ENSG00000109814 UGDH Breast Cancer 28971451
ENSG00000109814 UGDH tumor 29479058
ENSG00000109814 UGDH breast cancer 29713632
ENSG00000109814 UGDH lung cancer 30787260
ENSG00000109814 UGDH lung cancer 31243371
ENSG00000109814 UGDH breast cancer 31308490
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000109814 UGDH SARC 0.016 high
ENSG00000109814 UGDH UVM 0.03 high
ENSG00000109814 UGDH PAAD 0.012 high
ENSG00000109814 UGDH ACC 0.00034 high
ENSG00000109814 UGDH LGG 0.0025 high
ENSG00000109814 UGDH READ 0.028 low
ENSG00000109814 UGDH LUAD 0.011 high
ENSG00000109814 UGDH PCPG 0.028 low
ENSG00000109814 UGDH BRCA 0.0057 low
ENSG00000109814 UGDH COAD 0.027 low
ENSG00000109814 UGDH UCS 0.00041 low
ENSG00000109814 UGDH ESCA 0.034 high
ENSG00000109814 UGDH PRAD 0.023 high
ENSG00000109814 UGDH BLCA 0.036 high
ENSG00000109814 UGDH LIHC 0.0058 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000109814 UGDH LIHC Amp 1.441289 0.132992 0.732598 0.145946