Ensembl ID ENSG00000109062 Gene ID 9368 Accession 11075
Gene Symbol NHERF1 Alias EBP50;NHERF;NHE-RF;NHERF-1;NPHLOP2;SLC9A3R1 Full Name NHERF family PDZ scaffold protein 1
Position 17 : 74748628 - 74769353 Length 20726 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

ENSG00000109062 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000109062 1.86 2.57e-61 BRCA
ENSG00000109062 -1.1 4.33e-22 COAD
ENSG00000109062 2.59 5.83e-62 LUSC
ENSG00000109062 0.96 6.21e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000109062 breast cancers 11607833
ENSG00000109062 colorectal cancer 12830000
ENSG00000109062 breast cancer 15467753
ENSG00000109062 tumor 16456542
ENSG00000109062 tumour 17078868
ENSG00000109062 tumor 17311105
ENSG00000109062 tumor 17325659
ENSG00000109062 breast tumor 17332506
ENSG00000109062 breast cancer 17593079
ENSG00000109062 breast tumors 18190691
ENSG00000109062 breast cancer 18533032
ENSG00000109062 cancer 18781953
ENSG00000109062 tumors 19308292
ENSG00000109062 breast cancer 19912366
ENSG00000109062 tumor 20012548
ENSG00000109062 tumor 20736378
ENSG00000109062 tumor 20802536
ENSG00000109062 liver cancer 20937217
ENSG00000109062 Breast Cancer 21048827
ENSG00000109062 breast cancer 21079987
ENSG00000109062 colorectal cancer 21170265
ENSG00000109062 breast cancers 21203899
ENSG00000109062 familial breast cancer 21285147
ENSG00000109062 prostate cancer 21672215
ENSG00000109062 breast cancer 21707710
ENSG00000109062 colonic tumors 21761111
ENSG00000109062 tumor 21804599
ENSG00000109062 cancer 21822312
ENSG00000109062 gastric cancer 22366766
ENSG00000109062 tumor 22439624
ENSG00000109062 tumor 22440733
ENSG00000109062 cancer 22446018
ENSG00000109062 colorectal tumors 22466651
ENSG00000109062 tumor 22470852
ENSG00000109062 breast cancer 22476347
ENSG00000109062 tumor 22496422
ENSG00000109062 cancer 22523604
ENSG00000109062 pancreatic cancer 22622406
ENSG00000109062 colorectal cancer 22766563
ENSG00000109062 breast cancer 22992649
ENSG00000109062 tumor 23208378
ENSG00000109062 tumors 23397229
ENSG00000109062 hepatocellular cancer 23483729
ENSG00000109062 pancreatic cancer 23544174
ENSG00000109062 breast cancer 23775624
ENSG00000109062 tumor 23833653
ENSG00000109062 tumour 23991686
ENSG00000109062 cancer 24012959
ENSG00000109062 breast cancer 24086451
ENSG00000109062 tumor 24201803
ENSG00000109062 cancers 24339979
ENSG00000109062 cancer 24348097
ENSG00000109062 pancreatic cancer 24642259
ENSG00000109062 breast cancer 24844638
ENSG00000109062 cancer 24878819
ENSG00000109062 breast cancer 25119502
ENSG00000109062 pancreatic cancer 25120624
ENSG00000109062 tumor 25530180
ENSG00000109062 tumor 25555876
ENSG00000109062 lung tumors 25744438
ENSG00000109062 tumor 25748234
ENSG00000109062 tumor 25756512
ENSG00000109062 tumors 25775275
ENSG00000109062 Tumor 25897829
ENSG00000109062 cancer 26092975
ENSG00000109062 gastric cancer 26126066
ENSG00000109062 kidney cancer 26142394
ENSG00000109062 breast cancer 26218645
ENSG00000109062 breast cancer 26258011
ENSG00000109062 tumors 26312763
ENSG00000109062 tumor 26418977
ENSG00000109062 pancreatic cancer 26613085
ENSG00000109062 pancreatic cancer 26622484
ENSG00000109062 tumors 26788197
ENSG00000109062 cancer 26862730
ENSG00000109062 tumor 26867566
ENSG00000109062 metastatic prostate cancer 26893710
ENSG00000109062 Breast Cancer 26977012
ENSG00000109062 tumors 27097111
ENSG00000109062 tumors of the central nervous system 27229317
ENSG00000109062 liver cancer 27430982
ENSG00000109062 breast cancer 27448983
ENSG00000109062 cervical cancer 27509846
ENSG00000109062 colorectal cancer 27566107
ENSG00000109062 tumors 27753657
ENSG00000109062 metastatic colorectal cancer 27765918
ENSG00000109062 tumors 27823775
ENSG00000109062 colorectal cancer 27999191
ENSG00000109062 Breast Cancer 28011475
ENSG00000109062 cancer 28068322
ENSG00000109062 Cancer 28085111
ENSG00000109062 breast cancer 28235801
ENSG00000109062 tumors 28430808
ENSG00000109062 tumor 28454463
ENSG00000109062 tumor 28529637
ENSG00000109062 triple-negative breast cancer 28535016
ENSG00000109062 tumor 28684865
ENSG00000109062 Breast Cancer 28739728
ENSG00000109062 Lung Cancer 28739734
ENSG00000109062 cancer 28950951
ENSG00000109062 breast cancer 29029467
ENSG00000109062 tumors 29152120
ENSG00000109062 breast cancer 29283175
ENSG00000109062 tumor 29455084
ENSG00000109062 cancer 29520890
ENSG00000109062 colorectal cancer 29551770
ENSG00000109062 tumor 29716631
ENSG00000109062 tumor 29725468
ENSG00000109062 tumour 29846905
ENSG00000109062 tumor 29867145
ENSG00000109062 colon cancer 29901158
ENSG00000109062 brain tumors 29983887
ENSG00000109062 cancer 30038216
ENSG00000109062 cervical cancer 30230542
ENSG00000109062 breast cancer 30326259
ENSG00000109062 tumors 30463370
ENSG00000109062 breast cancers 30463939
ENSG00000109062 liver cancer 30581004
ENSG00000109062 cancer 31002735
ENSG00000109062 breast cancer 31087002
ENSG00000109062 tumors 31540486
ENSG00000109062 tumor 31711240
ENSG00000109062 Tumor 31865181
ENSG00000109062 colorectal cancer 31867736
ENSG00000109062 tumor 31984791
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000109062 MESO 0.0026 low
ENSG00000109062 SARC 0.039 low
ENSG00000109062 STAD 0.0095 low
ENSG00000109062 THCA 0.036 low
ENSG00000109062 ACC 0.00019 low
ENSG00000109062 LUSC 0.012 low
ENSG00000109062 READ 0.022 low
ENSG00000109062 KIRP 0.0059 low
ENSG00000109062 LUAD 0.019 high
ENSG00000109062 THYM 0.0028 low
ENSG00000109062 COAD 0.034 low
ENSG00000109062 ESCA 0.042 high
ENSG00000109062 KIRC 0.0024 low
ENSG00000109062 BLCA 0.0032 high
ENSG00000109062 LAML 0.025 high
ENSG00000109062 GBM 0.017 high
ENSG00000109062 CESC 0.038 high
ENSG00000109062 LIHC 0.00022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000109062 LUSC Amp 2.015661 0.236088 0.450680 0.471058
ENSG00000109062 LUAD Amp 2.353676 0.156879 0.401276 0.492248
ENSG00000109062 LGG Amp 2.338820 0.067725 0.570625 0.079922
ENSG00000109062 CESC Amp 2.913529 0.209025 0.673188 0.233898
ENSG00000109062 PAAD Del 3.747687 0.097674 0.355347 0.228261
ENSG00000109062 SKCM Amp 5.715045 0.259825 0.559237 0.348774
ENSG00000109062 LIHC Amp 7.499932 0.250255 0.664359 0.375676
ENSG00000109062 BLCA Amp 2.032497 0.210732 0.465621 0.473039
ENSG00000109062 BRCA Amp 23.528941 0.375837 0.664238 0.371296
ENSG00000109062 UCEC Amp 2.565091 0.143654 0.557884 0.165121