Ensembl ID ENSG00000108953 Gene ID 7531 Accession 12851
Gene Symbol YWHAE Alias MDS;HEL2;MDCR;KCIP-1;14-3-3E Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Position 17 : 1344275 - 1400222 Length 55948 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

ENSG00000108953 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108953 YWHAE 0.79 5.46e-22 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108953 YWHAE cancer 15519529
ENSG00000108953 YWHAE tumors 16773180
ENSG00000108953 YWHAE tumour 19397818
ENSG00000108953 YWHAE tumor 20975997
ENSG00000108953 YWHAE tumor 22223660
ENSG00000108953 YWHAE childhood cancer 22294382
ENSG00000108953 YWHAE tumour 22440772
ENSG00000108953 YWHAE tumor 22456610
ENSG00000108953 YWHAE tumor 23159154
ENSG00000108953 YWHAE tumor 23599159
ENSG00000108953 YWHAE tumors 23959973
ENSG00000108953 YWHAE tumors 24186140
ENSG00000108953 YWHAE tumours 24592973
ENSG00000108953 YWHAE tumors 25130488
ENSG00000108953 YWHAE tumors 25133706
ENSG00000108953 YWHAE tumor 25481751
ENSG00000108953 YWHAE tumours 25595274
ENSG00000108953 YWHAE inflammatory myofibroblastic tumor 25612511
ENSG00000108953 YWHAE tumors 26848979
ENSG00000108953 YWHAE tumors 26879382
ENSG00000108953 YWHAE tumours 26990025
ENSG00000108953 YWHAE uterine tumor 27142911
ENSG00000108953 YWHAE Endometrial Stromal Tumors 27154512
ENSG00000108953 YWHAE tumors 27219024
ENSG00000108953 YWHAE tumors 27428733
ENSG00000108953 YWHAE tumor 27863420
ENSG00000108953 YWHAE tumor 28288693
ENSG00000108953 YWHAE tumor 28432311
ENSG00000108953 YWHAE tumors 28621321
ENSG00000108953 YWHAE tumor 28863072
ENSG00000108953 YWHAE tumors 29192652
ENSG00000108953 YWHAE tumors 29200103
ENSG00000108953 YWHAE tumours 29275929
ENSG00000108953 YWHAE tumour 29357824
ENSG00000108953 YWHAE tumors 30144186
ENSG00000108953 YWHAE tumors 30149610
ENSG00000108953 YWHAE tumors 30324234
ENSG00000108953 YWHAE epithelial ovarian cancer 30678426
ENSG00000108953 YWHAE tumor 30697075
ENSG00000108953 YWHAE tumors 30789359
ENSG00000108953 YWHAE breast cancer 31001932
ENSG00000108953 YWHAE AML 31111215
ENSG00000108953 YWHAE colorectal cancer 31238337
ENSG00000108953 YWHAE colon cancer 31438886
ENSG00000108953 YWHAE mesenchymal tumors 31607703
ENSG00000108953 YWHAE Tumors 31615558
ENSG00000108953 YWHAE tumors 31768620
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000108953 YWHAE leiomyoma gene_fusion 50.0% (66/132) 1 entry
ENSG00000108953 YWHAE endometrial stromal sarcoma gene_fusion 46.3% (50/108) 1 entry
ENSG00000108953 YWHAE solitary fibrous tumor gene_fusion 33.33% (13/39) 1 entry
ENSG00000108953 YWHAE Gastrointestinal stromal tumor gene_fusion 45.13% (51/113) 1 entry
ENSG00000108953 YWHAE clear cell sarcoma gene_fusion 45.54% (51/112) 1 entry
ENSG00000108953 YWHAE embryonal rhabdomyosarcoma gene_fusion 12.0% (12/100) 1 entry
ENSG00000108953 YWHAE Dermatofibrosarcoma protuberans gene_fusion 47.62% (10/21) 1 entry
ENSG00000108953 YWHAE synovial sarcoma gene_fusion 37.5% (12/32) 1 entry
ENSG00000108953 YWHAE Ovarian Endometriosis gene_fusion 50.0% (7/14) 1 entry
ENSG00000108953 YWHAE leiomyosarcoma gene_fusion 49.84% (311/624) 1 entry
ENSG00000108953 YWHAE undifferentiated pleomorphic sarcoma gene_fusion 49.17% (59/120) 1 entry
ENSG00000108953 YWHAE Uterine Carcinosarcoma gene_fusion 13.38% (19/142) 1 entry
ENSG00000108953 YWHAE dedifferentiated liposarcoma gene_fusion 50.0% (12/24) 1 entry
ENSG00000108953 YWHAE malignant peripheral nerve sheath tumor gene_fusion 43.75% (7/16) 1 entry
ENSG00000108953 YWHAE angiosarcoma gene_fusion 38.18% (21/55) 1 entry
ENSG00000108953 YWHAE clear cell renal carcinoma sequence_alteration 0.4651% (6/1290) 1 entry
ENSG00000108953 YWHAE bladder carcinoma sequence_alteration 0.7207% (4/555) 1 entry
ENSG00000108953 YWHAE ovarian serous adenocarcinoma sequence_alteration 0.2972% (2/673) 1 entry
ENSG00000108953 YWHAE lung adenocarcinoma missense_variant 0.3279% (4/1220) 2 entries
ENSG00000108953 YWHAE cecum adenocarcinoma sequence_alteration 1.6% (2/125) 1 entry
ENSG00000108953 YWHAE melanoma sequence_alteration 1.98% (2/101) 2 entries
ENSG00000108953 YWHAE brain glioblastoma sequence_alteration 0.54% (5/926) 1 entry
ENSG00000108953 YWHAE prostate carcinoma sequence_alteration 2.066% (10/484) 1 entry
ENSG00000108953 YWHAE skin melanoma sequence_alteration 0.3102% (3/967) 1 entry
ENSG00000108953 YWHAE lung adenocarcinoma sequence_alteration 0.3279% (4/1220) 3 entries
ENSG00000108953 YWHAE colon adenocarcinoma missense_variant 1.524% (11/722) 2 entries
ENSG00000108953 YWHAE colon adenocarcinoma sequence_alteration 1.524% (11/722) 2 entries
ENSG00000108953 YWHAE clear cell renal carcinoma missense_variant 0.4651% (6/1290) 1 entry
ENSG00000108953 YWHAE melanoma missense_variant 1.98% (2/101) 2 entries
ENSG00000108953 YWHAE squamous cell lung carcinoma sequence_alteration 0.3636% (3/825) 1 entry
ENSG00000108953 YWHAE colorectal adenocarcinoma sequence_alteration 2.021% (23/1138) 2 entries
ENSG00000108953 YWHAE colorectal adenocarcinoma missense_variant 2.021% (23/1138) 2 entries
ENSG00000108953 YWHAE esophageal adenocarcinoma sequence_alteration 4.338% (19/438) 1 entry
ENSG00000108953 YWHAE breast carcinoma sequence_alteration 0.07087% (1/1411) 1 entry
ENSG00000108953 YWHAE pancreatic adenocarcinoma missense_variant 100.0% (1/1) 1 entry
ENSG00000108953 YWHAE breast carcinoma missense_variant 0.07087% (1/1411) 1 entry
ENSG00000108953 YWHAE basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000108953 YWHAE Pleural Sarcomatoid Mesothelioma sequence_alteration 16.67% (1/6) 1 entry
ENSG00000108953 YWHAE Pancreatic Acinar Cell Carcinoma sequence_alteration 5.0% (1/20) 1 entry
ENSG00000108953 YWHAE Gallbladder Adenocarcinoma sequence_alteration 1.149% (1/87) 1 entry
ENSG00000108953 YWHAE cecum adenocarcinoma missense_variant 1.6% (2/125) 1 entry
ENSG00000108953 YWHAE Pleural Sarcomatoid Mesothelioma missense_variant 16.67% (1/6) 1 entry
ENSG00000108953 YWHAE prostate carcinoma missense_variant 2.066% (10/484) 1 entry
ENSG00000108953 YWHAE basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000108953 YWHAE esophageal adenocarcinoma frameshift_variant 4.338% (19/438) 1 entry
ENSG00000108953 YWHAE ovarian serous adenocarcinoma stop_gained 0.2972% (2/673) 1 entry
ENSG00000108953 YWHAE ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108953 YWHAE SARC 0.00073 high
ENSG00000108953 YWHAE CHOL 0.012 high
ENSG00000108953 YWHAE UVM 0.0087 high
ENSG00000108953 YWHAE PAAD 0.027 low
ENSG00000108953 YWHAE THCA 0.018 low
ENSG00000108953 YWHAE ACC 0.0089 high
ENSG00000108953 YWHAE HNSC 0.026 high
ENSG00000108953 YWHAE KIRP 0.00048 low
ENSG00000108953 YWHAE KICH 0.0012 high
ENSG00000108953 YWHAE LUAD 0.002 high
ENSG00000108953 YWHAE THYM 0.043 low
ENSG00000108953 YWHAE ESCA 0.044 low
ENSG00000108953 YWHAE OV 0.04 low
ENSG00000108953 YWHAE KIRC 0.0014 low
ENSG00000108953 YWHAE LAML 0.044 high
ENSG00000108953 YWHAE SKCM 0.05 high
ENSG00000108953 YWHAE LIHC 0.023 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108953 YWHAE LUAD Del 2.741850 0.074485 0.366437 0.544574
ENSG00000108953 YWHAE SARC Del 4.941191 0.215687 0.531329 0.354086
ENSG00000108953 YWHAE LIHC Del 6.092188 0.132551 0.643192 0.559459
ENSG00000108953 YWHAE BRCA Del 2.005801 0.074583 0.483047 0.575926
ENSG00000108953 YWHAE STAD Del 1.364502 0.070213 0.384692 0.396825
ENSG00000108953 YWHAE UCEC Del 1.414628 0.057045 0.580971 0.220779