Ensembl ID ENSG00000108953 Gene ID 7531 Accession 12851
Gene Symbol YWHAE Alias MDS;HEL2;MDCR;KCIP-1;14-3-3E Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Position 17 : 1344275 - 1400222 Length 55948 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

ENSG00000108953 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108953 0.79 5.46e-22 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108953 cancer 15519529
ENSG00000108953 tumors 16773180
ENSG00000108953 tumour 19397818
ENSG00000108953 tumor 20975997
ENSG00000108953 tumor 22223660
ENSG00000108953 childhood cancer 22294382
ENSG00000108953 tumour 22440772
ENSG00000108953 tumor 22456610
ENSG00000108953 tumor 23159154
ENSG00000108953 tumor 23599159
ENSG00000108953 tumors 23959973
ENSG00000108953 tumors 24186140
ENSG00000108953 tumours 24592973
ENSG00000108953 tumors 25130488
ENSG00000108953 tumors 25133706
ENSG00000108953 tumor 25481751
ENSG00000108953 tumours 25595274
ENSG00000108953 inflammatory myofibroblastic tumor 25612511
ENSG00000108953 tumors 26848979
ENSG00000108953 tumors 26879382
ENSG00000108953 tumours 26990025
ENSG00000108953 uterine tumor 27142911
ENSG00000108953 Endometrial Stromal Tumors 27154512
ENSG00000108953 tumors 27219024
ENSG00000108953 tumors 27428733
ENSG00000108953 tumor 27863420
ENSG00000108953 tumor 28288693
ENSG00000108953 tumor 28432311
ENSG00000108953 tumors 28621321
ENSG00000108953 tumor 28863072
ENSG00000108953 tumors 29192652
ENSG00000108953 tumors 29200103
ENSG00000108953 tumours 29275929
ENSG00000108953 tumour 29357824
ENSG00000108953 tumors 30144186
ENSG00000108953 tumors 30149610
ENSG00000108953 tumors 30324234
ENSG00000108953 epithelial ovarian cancer 30678426
ENSG00000108953 tumor 30697075
ENSG00000108953 tumors 30789359
ENSG00000108953 breast cancer 31001932
ENSG00000108953 AML 31111215
ENSG00000108953 colorectal cancer 31238337
ENSG00000108953 colon cancer 31438886
ENSG00000108953 mesenchymal tumors 31607703
ENSG00000108953 Tumors 31615558
ENSG00000108953 tumors 31768620
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000108953 leiomyoma gene_fusion 50.0% (66/132) 1 entry
ENSG00000108953 endometrial stromal sarcoma gene_fusion 46.3% (50/108) 1 entry
ENSG00000108953 solitary fibrous tumor gene_fusion 33.33% (13/39) 1 entry
ENSG00000108953 Gastrointestinal stromal tumor gene_fusion 45.13% (51/113) 1 entry
ENSG00000108953 clear cell sarcoma gene_fusion 45.54% (51/112) 1 entry
ENSG00000108953 embryonal rhabdomyosarcoma gene_fusion 12.0% (12/100) 1 entry
ENSG00000108953 Dermatofibrosarcoma protuberans gene_fusion 47.62% (10/21) 1 entry
ENSG00000108953 synovial sarcoma gene_fusion 37.5% (12/32) 1 entry
ENSG00000108953 Ovarian Endometriosis gene_fusion 50.0% (7/14) 1 entry
ENSG00000108953 leiomyosarcoma gene_fusion 49.84% (311/624) 1 entry
ENSG00000108953 undifferentiated pleomorphic sarcoma gene_fusion 49.17% (59/120) 1 entry
ENSG00000108953 Uterine Carcinosarcoma gene_fusion 13.38% (19/142) 1 entry
ENSG00000108953 dedifferentiated liposarcoma gene_fusion 50.0% (12/24) 1 entry
ENSG00000108953 malignant peripheral nerve sheath tumor gene_fusion 43.75% (7/16) 1 entry
ENSG00000108953 angiosarcoma gene_fusion 38.18% (21/55) 1 entry
ENSG00000108953 clear cell renal carcinoma sequence_alteration 0.4651% (6/1290) 1 entry
ENSG00000108953 bladder carcinoma sequence_alteration 0.7207% (4/555) 1 entry
ENSG00000108953 ovarian serous adenocarcinoma sequence_alteration 0.2972% (2/673) 1 entry
ENSG00000108953 lung adenocarcinoma missense_variant 0.3279% (4/1220) 2 entries
ENSG00000108953 cecum adenocarcinoma sequence_alteration 1.6% (2/125) 1 entry
ENSG00000108953 melanoma sequence_alteration 1.98% (2/101) 2 entries
ENSG00000108953 brain glioblastoma sequence_alteration 0.54% (5/926) 1 entry
ENSG00000108953 prostate carcinoma sequence_alteration 2.066% (10/484) 1 entry
ENSG00000108953 skin melanoma sequence_alteration 0.3102% (3/967) 1 entry
ENSG00000108953 lung adenocarcinoma sequence_alteration 0.3279% (4/1220) 3 entries
ENSG00000108953 colon adenocarcinoma missense_variant 1.524% (11/722) 2 entries
ENSG00000108953 colon adenocarcinoma sequence_alteration 1.524% (11/722) 2 entries
ENSG00000108953 clear cell renal carcinoma missense_variant 0.4651% (6/1290) 1 entry
ENSG00000108953 melanoma missense_variant 1.98% (2/101) 2 entries
ENSG00000108953 squamous cell lung carcinoma sequence_alteration 0.3636% (3/825) 1 entry
ENSG00000108953 colorectal adenocarcinoma sequence_alteration 2.021% (23/1138) 2 entries
ENSG00000108953 colorectal adenocarcinoma missense_variant 2.021% (23/1138) 2 entries
ENSG00000108953 esophageal adenocarcinoma sequence_alteration 4.338% (19/438) 1 entry
ENSG00000108953 breast carcinoma sequence_alteration 0.07087% (1/1411) 1 entry
ENSG00000108953 pancreatic adenocarcinoma missense_variant 100.0% (1/1) 1 entry
ENSG00000108953 breast carcinoma missense_variant 0.07087% (1/1411) 1 entry
ENSG00000108953 basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000108953 Pleural Sarcomatoid Mesothelioma sequence_alteration 16.67% (1/6) 1 entry
ENSG00000108953 Pancreatic Acinar Cell Carcinoma sequence_alteration 5.0% (1/20) 1 entry
ENSG00000108953 Gallbladder Adenocarcinoma sequence_alteration 1.149% (1/87) 1 entry
ENSG00000108953 cecum adenocarcinoma missense_variant 1.6% (2/125) 1 entry
ENSG00000108953 Pleural Sarcomatoid Mesothelioma missense_variant 16.67% (1/6) 1 entry
ENSG00000108953 prostate carcinoma missense_variant 2.066% (10/484) 1 entry
ENSG00000108953 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000108953 esophageal adenocarcinoma frameshift_variant 4.338% (19/438) 1 entry
ENSG00000108953 ovarian serous adenocarcinoma stop_gained 0.2972% (2/673) 1 entry
ENSG00000108953 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108953 SARC 0.00073 high
ENSG00000108953 CHOL 0.012 high
ENSG00000108953 UVM 0.0087 high
ENSG00000108953 PAAD 0.027 low
ENSG00000108953 THCA 0.018 low
ENSG00000108953 ACC 0.0089 high
ENSG00000108953 HNSC 0.026 high
ENSG00000108953 KIRP 0.00048 low
ENSG00000108953 KICH 0.0012 high
ENSG00000108953 LUAD 0.002 high
ENSG00000108953 THYM 0.043 low
ENSG00000108953 ESCA 0.044 low
ENSG00000108953 OV 0.04 low
ENSG00000108953 KIRC 0.0014 low
ENSG00000108953 LAML 0.044 high
ENSG00000108953 SKCM 0.05 high
ENSG00000108953 LIHC 0.023 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108953 LUAD Del 2.741850 0.074485 0.366437 0.544574
ENSG00000108953 SARC Del 4.941191 0.215687 0.531329 0.354086
ENSG00000108953 LIHC Del 6.092188 0.132551 0.643192 0.559459
ENSG00000108953 BRCA Del 2.005801 0.074583 0.483047 0.575926
ENSG00000108953 STAD Del 1.364502 0.070213 0.384692 0.396825
ENSG00000108953 UCEC Del 1.414628 0.057045 0.580971 0.220779