Ensembl ID
ENSG00000108654
Gene ID
1655
Accession
2746
Gene Symbol
DDX5
Alias
p68;HLR1;G17P1;HUMP68
Full Name
DEAD-box helicase 5
Position
17 : 64498254 - 64507712
Length
9459 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]
ENSG00000108654 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000108654
DDX5
-0.4
8.24e-15
LUSC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000108654
DDX5
tumours
11753651
ENSG00000108654
DDX5
ovarian tumors
12532422
ENSG00000108654
DDX5
lung cancer
17540040
ENSG00000108654
DDX5
colon cancer
17699760
ENSG00000108654
DDX5
prostate cancer
18794152
ENSG00000108654
DDX5
prostate cancer
18829551
ENSG00000108654
DDX5
tumour
20225156
ENSG00000108654
DDX5
tumor
20589163
ENSG00000108654
DDX5
breast cancer
20818423
ENSG00000108654
DDX5
gastric cancer
21277973
ENSG00000108654
DDX5
cancer
21345143
ENSG00000108654
DDX5
bladder cancer
21672358
ENSG00000108654
DDX5
breast cancer
21731475
ENSG00000108654
DDX5
tumor
21937682
ENSG00000108654
DDX5
breast cancer
22086602
ENSG00000108654
DDX5
tumor
22370639
ENSG00000108654
DDX5
tumor
22415314
ENSG00000108654
DDX5
tumor
22492723
ENSG00000108654
DDX5
cancer
22750847
ENSG00000108654
DDX5
tumour
22986526
ENSG00000108654
DDX5
prostate cancer
23349811
ENSG00000108654
DDX5
tumor
24469041
ENSG00000108654
DDX5
breast cancers
24626184
ENSG00000108654
DDX5
cancer
24796549
ENSG00000108654
DDX5
tumor
24965446
ENSG00000108654
DDX5
cancer
25150365
ENSG00000108654
DDX5
cancer
25499975
ENSG00000108654
DDX5
cancers
25745998
ENSG00000108654
DDX5
cancer
26202601
ENSG00000108654
DDX5
non-small-cell lung cancer
26212035
ENSG00000108654
DDX5
colorectal cancers
26311743
ENSG00000108654
DDX5
ovarian cancer
26513874
ENSG00000108654
DDX5
tumour
26739063
ENSG00000108654
DDX5
prostate cancer
27148684
ENSG00000108654
DDX5
tumor
27323415
ENSG00000108654
DDX5
liver tumor
27338022
ENSG00000108654
DDX5
Cancer
27889881
ENSG00000108654
DDX5
gastric cancer
28216662
ENSG00000108654
DDX5
Esophageal Cancer
28244855
ENSG00000108654
DDX5
cancer
28411202
ENSG00000108654
DDX5
Cancer
28751441
ENSG00000108654
DDX5
cancer
29146961
ENSG00000108654
DDX5
cancers
29227193
ENSG00000108654
DDX5
tumors
29522752
ENSG00000108654
DDX5
gastric cancer
29540201
ENSG00000108654
DDX5
cancer
29642538
ENSG00000108654
DDX5
GBM
29687002
ENSG00000108654
DDX5
cancer
29729328
ENSG00000108654
DDX5
colorectal cancer
29988738
ENSG00000108654
DDX5
gastric cancer
30029874
ENSG00000108654
DDX5
tumours
30119889
ENSG00000108654
DDX5
tumor
30185232
ENSG00000108654
DDX5
cancer
30281815
ENSG00000108654
DDX5
cancer
30293550
ENSG00000108654
DDX5
breast tumor
30413718
ENSG00000108654
DDX5
breast cancer
30417346
ENSG00000108654
DDX5
colorectal cancer
30484950
ENSG00000108654
DDX5
cancer
30506978
ENSG00000108654
DDX5
breast cancer
30678233
ENSG00000108654
DDX5
lung cancer
30720177
ENSG00000108654
DDX5
breast cancer
30733679
ENSG00000108654
DDX5
breast cancer
31015574
ENSG00000108654
DDX5
Endometrial Cancer
31032220
ENSG00000108654
DDX5
prostate cancer
31164793
ENSG00000108654
DDX5
colon cancer
31351496
ENSG00000108654
DDX5
Prostate Cancer
31387890
ENSG00000108654
DDX5
tumor
31510013
ENSG00000108654
DDX5
cancer
31548374
ENSG00000108654
DDX5
tumor
31982037
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000108654
DDX5
MESO
0.0029
low
show
ENSG00000108654
DDX5
SARC
0.017
low
show
ENSG00000108654
DDX5
CHOL
0.029
low
show
ENSG00000108654
DDX5
PAAD
0.0025
low
show
ENSG00000108654
DDX5
LUSC
0.026
high
show
ENSG00000108654
DDX5
READ
0.0075
low
show
ENSG00000108654
DDX5
KIRP
0.031
low
show
ENSG00000108654
DDX5
LUAD
0.012
low
show
ENSG00000108654
DDX5
THYM
0.013
low
show
ENSG00000108654
DDX5
BRCA
0.042
low
show
ENSG00000108654
DDX5
COAD
0.0033
low
show
ENSG00000108654
DDX5
UCS
0.0059
low
show
ENSG00000108654
DDX5
OV
0.05
low
show
ENSG00000108654
DDX5
BLCA
0.0087
low
show
ENSG00000108654
DDX5
GBM
0.047
low
show
ENSG00000108654
DDX5
SKCM
0.00011
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000108654
DDX5
LUSC
Amp
0.701353
0.193414
0.438799
0.451098
ENSG00000108654
DDX5
PAAD
Del
4.026560
0.104735
0.373082
0.222826
ENSG00000108654
DDX5
SKCM
Amp
4.812877
0.237699
0.554642
0.335150
ENSG00000108654
DDX5
LIHC
Amp
5.395962
0.214253
0.653107
0.359459
ENSG00000108654
DDX5
BLCA
Amp
3.230182
0.245736
0.505594
0.473039
ENSG00000108654
DDX5
BRCA
Amp
52.063789
0.561129
0.852980
0.394444
ENSG00000108654
DDX5
UCEC
Amp
0.820943
0.106086
0.576775
0.124304
ENSG00000108654
DDX5
UVM
Amp
0.721460
0.165534
0.811066
0.162500
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