Ensembl ID ENSG00000108654 Gene ID 1655 Accession 2746
Gene Symbol DDX5 Alias p68;HLR1;G17P1;HUMP68 Full Name DEAD-box helicase 5
Position 17 : 64498254 - 64507712 Length 9459 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

ENSG00000108654 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108654 -0.4 8.24e-15 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108654 tumours 11753651
ENSG00000108654 ovarian tumors 12532422
ENSG00000108654 lung cancer 17540040
ENSG00000108654 colon cancer 17699760
ENSG00000108654 prostate cancer 18794152
ENSG00000108654 prostate cancer 18829551
ENSG00000108654 tumour 20225156
ENSG00000108654 tumor 20589163
ENSG00000108654 breast cancer 20818423
ENSG00000108654 gastric cancer 21277973
ENSG00000108654 cancer 21345143
ENSG00000108654 bladder cancer 21672358
ENSG00000108654 breast cancer 21731475
ENSG00000108654 tumor 21937682
ENSG00000108654 breast cancer 22086602
ENSG00000108654 tumor 22370639
ENSG00000108654 tumor 22415314
ENSG00000108654 tumor 22492723
ENSG00000108654 cancer 22750847
ENSG00000108654 tumour 22986526
ENSG00000108654 prostate cancer 23349811
ENSG00000108654 tumor 24469041
ENSG00000108654 breast cancers 24626184
ENSG00000108654 cancer 24796549
ENSG00000108654 tumor 24965446
ENSG00000108654 cancer 25150365
ENSG00000108654 cancer 25499975
ENSG00000108654 cancers 25745998
ENSG00000108654 cancer 26202601
ENSG00000108654 non-small-cell lung cancer 26212035
ENSG00000108654 colorectal cancers 26311743
ENSG00000108654 ovarian cancer 26513874
ENSG00000108654 tumour 26739063
ENSG00000108654 prostate cancer 27148684
ENSG00000108654 tumor 27323415
ENSG00000108654 liver tumor 27338022
ENSG00000108654 Cancer 27889881
ENSG00000108654 gastric cancer 28216662
ENSG00000108654 Esophageal Cancer 28244855
ENSG00000108654 cancer 28411202
ENSG00000108654 Cancer 28751441
ENSG00000108654 cancer 29146961
ENSG00000108654 cancers 29227193
ENSG00000108654 tumors 29522752
ENSG00000108654 gastric cancer 29540201
ENSG00000108654 cancer 29642538
ENSG00000108654 GBM 29687002
ENSG00000108654 cancer 29729328
ENSG00000108654 colorectal cancer 29988738
ENSG00000108654 gastric cancer 30029874
ENSG00000108654 tumours 30119889
ENSG00000108654 tumor 30185232
ENSG00000108654 cancer 30281815
ENSG00000108654 cancer 30293550
ENSG00000108654 breast tumor 30413718
ENSG00000108654 breast cancer 30417346
ENSG00000108654 colorectal cancer 30484950
ENSG00000108654 cancer 30506978
ENSG00000108654 breast cancer 30678233
ENSG00000108654 lung cancer 30720177
ENSG00000108654 breast cancer 30733679
ENSG00000108654 breast cancer 31015574
ENSG00000108654 Endometrial Cancer 31032220
ENSG00000108654 prostate cancer 31164793
ENSG00000108654 colon cancer 31351496
ENSG00000108654 Prostate Cancer 31387890
ENSG00000108654 tumor 31510013
ENSG00000108654 cancer 31548374
ENSG00000108654 tumor 31982037
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000108654 colorectal adenocarcinoma missense_variant 2.724% (31/1138) 2 entries
ENSG00000108654 colon adenocarcinoma missense_variant 2.632% (19/722) 3 entries
ENSG00000108654 colon adenocarcinoma sequence_alteration 2.632% (19/722) 3 entries
ENSG00000108654 colorectal adenocarcinoma sequence_alteration 2.724% (31/1138) 2 entries
ENSG00000108654 lung adenocarcinoma missense_variant 0.8598% (10/1163) 4 entries
ENSG00000108654 gastric adenocarcinoma missense_variant 1.075% (6/558) 2 entries
ENSG00000108654 colon adenocarcinoma frameshift_variant 2.632% (19/722) 1 entry
ENSG00000108654 skin melanoma missense_variant 1.034% (10/967) 1 entry
ENSG00000108654 breast carcinoma sequence_alteration 0.4252% (6/1411) 1 entry
ENSG00000108654 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000108654 breast carcinoma missense_variant 0.4252% (6/1411) 1 entry
ENSG00000108654 chronic lymphocytic leukemia sequence_alteration 0.2252% (2/888) 1 entry
ENSG00000108654 hemangioblastoma sequence_alteration 9.375% (3/32) 1 entry
ENSG00000108654 metaplastic breast carcinoma missense_variant 3.922% (2/51) 1 entry
ENSG00000108654 esophageal squamous cell carcinoma sequence_alteration 0.7407% (5/675) 2 entries
ENSG00000108654 prostate carcinoma sequence_alteration 0.4695% (2/426) 1 entry
ENSG00000108654 oral squamous cell carcinoma missense_variant 1.942% (4/206) 3 entries
ENSG00000108654 colorectal adenocarcinoma stop_gained 2.724% (31/1138) 1 entry
ENSG00000108654 lung adenocarcinoma sequence_alteration 0.8598% (10/1163) 4 entries
ENSG00000108654 hepatocellular carcinoma missense_variant 0.5562% (5/899) 1 entry
ENSG00000108654 breast carcinoma frameshift_variant 0.4252% (6/1411) 1 entry
ENSG00000108654 colorectal adenocarcinoma frameshift_variant 2.724% (31/1138) 1 entry
ENSG00000108654 squamous cell lung carcinoma sequence_alteration 0.3937% (3/762) 1 entry
ENSG00000108654 prostate adenocarcinoma sequence_alteration 0.206% (3/1456) 1 entry
ENSG00000108654 colon adenoma missense_variant 5.882% (1/17) 1 entry
ENSG00000108654 basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000108654 esophageal adenocarcinoma frameshift_variant 0.9132% (4/438) 1 entry
ENSG00000108654 bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000108654 esophageal adenocarcinoma missense_variant 0.9132% (4/438) 1 entry
ENSG00000108654 brain glioblastoma sequence_alteration 0.108% (1/926) 1 entry
ENSG00000108654 cecum adenocarcinoma missense_variant 1.6% (2/125) 1 entry
ENSG00000108654 esophageal squamous cell carcinoma conservative_inframe_deletion 0.7407% (5/675) 1 entry
ENSG00000108654 clear cell renal carcinoma missense_variant 0.1451% (2/1378) 1 entry
ENSG00000108654 colon adenoma sequence_alteration 5.882% (1/17) 1 entry
ENSG00000108654 female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000108654 lung carcinoid tumor missense_variant 9.091% (1/11) 1 entry
ENSG00000108654 hemangioblastoma frameshift_variant 9.375% (3/32) 1 entry
ENSG00000108654 prostate adenocarcinoma gene_fusion 0.206% (3/1456) 1 entry
ENSG00000108654 hemangioblastoma missense_variant 9.375% (3/32) 1 entry
ENSG00000108654 melanoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000108654 diffuse large B-cell lymphoma missense_variant 0.3289% (1/304) 1 entry
ENSG00000108654 cecum adenocarcinoma sequence_alteration 1.6% (2/125) 1 entry
ENSG00000108654 nasopharyngeal squamous cell carcinoma missense_variant 0.5988% (1/167) 1 entry
ENSG00000108654 esophageal squamous cell carcinoma missense_variant 0.7407% (5/675) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108654 MESO 0.0029 low
ENSG00000108654 SARC 0.017 low
ENSG00000108654 CHOL 0.029 low
ENSG00000108654 PAAD 0.0025 low
ENSG00000108654 LUSC 0.026 high
ENSG00000108654 READ 0.0075 low
ENSG00000108654 KIRP 0.031 low
ENSG00000108654 LUAD 0.012 low
ENSG00000108654 THYM 0.013 low
ENSG00000108654 BRCA 0.042 low
ENSG00000108654 COAD 0.0033 low
ENSG00000108654 UCS 0.0059 low
ENSG00000108654 OV 0.05 low
ENSG00000108654 BLCA 0.0087 low
ENSG00000108654 GBM 0.047 low
ENSG00000108654 SKCM 0.00011 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108654 LUSC Amp 0.701353 0.193414 0.438799 0.451098
ENSG00000108654 PAAD Del 4.026560 0.104735 0.373082 0.222826
ENSG00000108654 SKCM Amp 4.812877 0.237699 0.554642 0.335150
ENSG00000108654 LIHC Amp 5.395962 0.214253 0.653107 0.359459
ENSG00000108654 BLCA Amp 3.230182 0.245736 0.505594 0.473039
ENSG00000108654 BRCA Amp 52.063789 0.561129 0.852980 0.394444
ENSG00000108654 UCEC Amp 0.820943 0.106086 0.576775 0.124304
ENSG00000108654 UVM Amp 0.721460 0.165534 0.811066 0.162500