Ensembl ID ENSG00000108518 Gene ID 5216 Accession 8881
Gene Symbol PFN1 Alias ALS18 Full Name profilin 1
Position 17 : 4945652 - 4949061 Length 3410 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

ENSG00000108518 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108518 0.65 1.47e-20 KIRC
ENSG00000108518 0.64 2.26e-11 HNSC
ENSG00000108518 0.90 4.21e-48 BRCA
ENSG00000108518 1.61 2.30e-13 GBM
ENSG00000108518 1.06 1.99e-29 KIRP
ENSG00000108518 0.78 4.12e-12 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108518 Breast Cancer 10811861
ENSG00000108518 tumors 14767055
ENSG00000108518 pancreatic cancer 16215274
ENSG00000108518 tumor 17051635
ENSG00000108518 tumor 17051643
ENSG00000108518 breast cancer 17940506
ENSG00000108518 breast cancer 18937284
ENSG00000108518 breast cancer 19115233
ENSG00000108518 breast cancer 19593789
ENSG00000108518 ovarian cancer 19936259
ENSG00000108518 breast cancer 20143334
ENSG00000108518 tumor 21091798
ENSG00000108518 breast cancer 21115820
ENSG00000108518 tumor 21136970
ENSG00000108518 breast cancer 21692986
ENSG00000108518 tumor 21860587
ENSG00000108518 bladder cancer 22159600
ENSG00000108518 AML 22169282
ENSG00000108518 tumor 22415225
ENSG00000108518 tumor 22479341
ENSG00000108518 cancer 22761335
ENSG00000108518 tumor 23326535
ENSG00000108518 cancer 23331014
ENSG00000108518 triple-negative breast cancer 23430586
ENSG00000108518 breast cancer 23576398
ENSG00000108518 malignant tumor 23677805
ENSG00000108518 breast cancer 23686314
ENSG00000108518 pancreatic cancer 23826918
ENSG00000108518 Cancer 23827010
ENSG00000108518 Cancer 24465723
ENSG00000108518 breast cancer 24520372
ENSG00000108518 cancers 24587265
ENSG00000108518 breast cancer 24661873
ENSG00000108518 tumour 24747440
ENSG00000108518 gastric cancer 24828259
ENSG00000108518 breast cancer 25084196
ENSG00000108518 pancreatic cancer 25103363
ENSG00000108518 breast cancer 25454514
ENSG00000108518 pancreatic cancer 25502777
ENSG00000108518 breast cancer 25613364
ENSG00000108518 tumor 25681442
ENSG00000108518 tumors 25704627
ENSG00000108518 gastric cancer 25741138
ENSG00000108518 ovarian cancer 25927284
ENSG00000108518 breast cancer 26176334
ENSG00000108518 tumor 26325675
ENSG00000108518 bladder cancer 26889680
ENSG00000108518 Breast cancer 27081087
ENSG00000108518 breast cancer 27188458
ENSG00000108518 tumor 27494863
ENSG00000108518 lung cancer 27496138
ENSG00000108518 cancer 27669692
ENSG00000108518 tumor 27683119
ENSG00000108518 tumor 27862305
ENSG00000108518 bladder cancer 28149930
ENSG00000108518 Breast Cancer 28170369
ENSG00000108518 breast cancer 28423180
ENSG00000108518 tumor 28473981
ENSG00000108518 tumor 28688208
ENSG00000108518 breast cancer 28699810
ENSG00000108518 basal like breast cancer 29333087
ENSG00000108518 cancer 29945297
ENSG00000108518 cancer 30015842
ENSG00000108518 breast cancer 30318519
ENSG00000108518 cancer 30367810
ENSG00000108518 tumors 30468988
ENSG00000108518 cancer 30538497
ENSG00000108518 tumor 30638858
ENSG00000108518 breast cancer 31084432
ENSG00000108518 cancer 31454697
ENSG00000108518 tumor 31550443
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108518 MESO 0.00046 high
ENSG00000108518 CHOL 0.021 high
ENSG00000108518 PAAD 0.014 high
ENSG00000108518 UCEC 0.0044 low
ENSG00000108518 THCA 0.011 low
ENSG00000108518 ACC 0.0035 high
ENSG00000108518 HNSC 0.015 high
ENSG00000108518 KIRP 0.035 low
ENSG00000108518 KICH 0.04 high
ENSG00000108518 LUAD 0.0022 high
ENSG00000108518 THYM 0.00059 low
ENSG00000108518 BRCA 0.049 low
ENSG00000108518 UCS 0.04 high
ENSG00000108518 OV 0.00093 low
ENSG00000108518 LAML 0.00095 high
ENSG00000108518 SKCM 0.047 high
ENSG00000108518 LIHC 0.0033 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108518 LUAD Del 0.749323 0.051825 0.365025 0.531008
ENSG00000108518 SARC Del 7.231951 0.253180 0.575719 0.377432
ENSG00000108518 GBM Del 1.103421 0.057228 0.459067 0.150780
ENSG00000108518 LIHC Del 4.745145 0.118799 0.650637 0.583784
ENSG00000108518 PCPG Del 0.664750 0.056806 0.645666 0.395062
ENSG00000108518 PRAD Del 2.046605 0.088680 0.501834 0.209350