Ensembl ID ENSG00000108387 Gene ID 5414 Accession 9165
Gene Symbol SEPTIN4 Alias H5;ARTS;MART;SEP4;CE5B3;SEPT4;PNUTL2;hucep-7;BRADEION;C17orf47;hCDCREL-2 Full Name septin 4
Position 17 : 58520250 - 58544368 Length 24119 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

ENSG00000108387 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108387 SEPT4 1.13 1.88e-25 KIRC
ENSG00000108387 SEPT4 -0.7 9.08e-17 BRCA
ENSG00000108387 SEPT4 -2.1 2.92e-56 LUSC
ENSG00000108387 SEPT4 -3.2 5.85e-11 GBM
ENSG00000108387 SEPT4 -1.4 4.18e-14 KIRP
ENSG00000108387 SEPT4 -2.7 7.82e-18 CHOL
ENSG00000108387 SEPT4 -1.5 1.44e-47 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108387 SEPT4 tumor 11167005
ENSG00000108387 SEPT4 tumor 21949740
ENSG00000108387 SEPT4 tumor 21992730
ENSG00000108387 SEPT4 tumor 25790304
ENSG00000108387 SEPT4 tumor 27119499
ENSG00000108387 SEPT4 tumour 27269053
ENSG00000108387 SEPT4 tumor 29460395
ENSG00000108387 SEPT4 cancer 30029628
ENSG00000108387 SEPT4 tumor 30389919
ENSG00000108387 SEPT4 cancer 30983862
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108387 SEPT4 STAD 0.0011 high
ENSG00000108387 SEPT4 UVM 0.042 low
ENSG00000108387 SEPT4 PAAD 0.018 low
ENSG00000108387 SEPT4 LGG 0.0021 low
ENSG00000108387 SEPT4 LUSC 0.047 high
ENSG00000108387 SEPT4 HNSC 0.007 low
ENSG00000108387 SEPT4 LUAD 0.0044 low
ENSG00000108387 SEPT4 COAD 0.0011 high
ENSG00000108387 SEPT4 OV 0.043 low
ENSG00000108387 SEPT4 KIRC 0.00087 high
ENSG00000108387 SEPT4 BLCA 0.0024 high
ENSG00000108387 SEPT4 SKCM 0.031 low
ENSG00000108387 SEPT4 CESC 0.018 high
ENSG00000108387 SEPT4 LIHC 0.0048 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108387 SEPT4 LGG Amp 1.687531 0.058477 0.568330 0.070175
ENSG00000108387 SEPT4 PAAD Del 7.783104 0.147688 0.392214 0.266304
ENSG00000108387 SEPT4 SKCM Amp 3.620762 0.206862 0.537499 0.321526
ENSG00000108387 SEPT4 LIHC Amp 4.079130 0.189923 0.662914 0.340541
ENSG00000108387 SEPT4 BLCA Amp 1.240985 0.184488 0.484503 0.438725
ENSG00000108387 SEPT4 BRCA Amp 42.565834 0.503251 0.862580 0.354630