Ensembl ID ENSG00000108349 Gene ID 22794 Accession 17040
Gene Symbol CASC3 Alias BTZ;MLN51 Full Name CASC3 exon junction complex subunit
Position 17 : 40140537 - 40172171 Length 31635 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

ENSG00000108349 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108349 CASC3 -0.6 1.14e-11 KICH
ENSG00000108349 CASC3 0.62 2.31e-20 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108349 CASC3 breast cancer 12080473
ENSG00000108349 CASC3 breast cancer 15166247
ENSG00000108349 CASC3 breast cancer 17101062
ENSG00000108349 CASC3 malignant tumours 17652158
ENSG00000108349 CASC3 breast cancers 18332872
ENSG00000108349 CASC3 gastric cancers 20633762
ENSG00000108349 CASC3 Tumour 21806841
ENSG00000108349 CASC3 tumors 23383345
ENSG00000108349 CASC3 cancer 24080205
ENSG00000108349 CASC3 breast cancer 25205763
ENSG00000108349 CASC3 tumor 27029030
ENSG00000108349 CASC3 triple-negative breast cancer 28132893
ENSG00000108349 CASC3 tumor 29515784
ENSG00000108349 CASC3 cancer 30201882
ENSG00000108349 CASC3 tumors 30529689
ENSG00000108349 CASC3 tumor 30845975
ENSG00000108349 CASC3 tumor 31105871
ENSG00000108349 CASC3 tumors 31817163
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108349 CASC3 MESO 0.024 high
ENSG00000108349 CASC3 PAAD 0.0027 low
ENSG00000108349 CASC3 UCEC 0.034 low
ENSG00000108349 CASC3 ACC 0.00067 high
ENSG00000108349 CASC3 HNSC 0.022 low
ENSG00000108349 CASC3 KICH 0.00025 high
ENSG00000108349 CASC3 LUAD 0.0016 low
ENSG00000108349 CASC3 THYM 0.0011 low
ENSG00000108349 CASC3 BRCA 0.042 high
ENSG00000108349 CASC3 COAD 0.039 high
ENSG00000108349 CASC3 UCS 0.029 low
ENSG00000108349 CASC3 OV 0.0039 high
ENSG00000108349 CASC3 KIRC 0.0069 low
ENSG00000108349 CASC3 BLCA 0.0095 high
ENSG00000108349 CASC3 LAML 0.0051 low
ENSG00000108349 CASC3 SKCM 0.026 high
ENSG00000108349 CASC3 LIHC 0.0046 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108349 CASC3 ACC Del 2.749976 0.174427 0.591741 0.244444
ENSG00000108349 CASC3 COAD Amp 6.006958 0.156110 0.606738 0.243902
ENSG00000108349 CASC3 SARC Del 0.934741 0.128486 0.443780 0.260700
ENSG00000108349 CASC3 PAAD Amp 0.633560 0.078312 0.470626 0.152174
ENSG00000108349 CASC3 ESCA Amp 7.493480 0.575629 0.864422 0.385870
ENSG00000108349 CASC3 PCPG Del 3.439274 0.108933 0.648244 0.209877
ENSG00000108349 CASC3 BRCA Amp 49.215567 0.543975 1.125213 0.267593
ENSG00000108349 CASC3 BRCA Del 1.809219 0.073179 0.424125 0.278704
ENSG00000108349 CASC3 STAD Amp 25.407513 0.544095 0.932222 0.287982
ENSG00000108349 CASC3 UCEC Amp 3.000910 0.151073 0.888933 0.092764
ENSG00000108349 CASC3 UCEC Del 1.885700 0.062267 0.564648 0.179963