Ensembl ID ENSG00000108312 Gene ID 7343 Accession 12511
Gene Symbol UBTF Alias UBF;UBF1;UBF2;UBF-1;CONDBA;NOR-90 Full Name upstream binding transcription factor
Position 17 : 44205033 - 44221626 Length 16594 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Non-canonical_RBPs
Summary This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

ENSG00000108312 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108312 UBTF -0.3 2.89e-17 KIRC
ENSG00000108312 UBTF 0.39 3.35e-27 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108312 UBTF cancer 11874979
ENSG00000108312 UBTF tumor 16924243
ENSG00000108312 UBTF tumour 21418567
ENSG00000108312 UBTF tumor 22158478
ENSG00000108312 UBTF tumour 22731742
ENSG00000108312 UBTF cancer 23517060
ENSG00000108312 UBTF breast cancer 23690862
ENSG00000108312 UBTF cancer 25345917
ENSG00000108312 UBTF tumour 25551296
ENSG00000108312 UBTF tumors 25890091
ENSG00000108312 UBTF cancer 26317157
ENSG00000108312 UBTF tumor 26415219
ENSG00000108312 UBTF liver cancer 26657029
ENSG00000108312 UBTF tumour 27589844
ENSG00000108312 UBTF colon cancer 28692053
ENSG00000108312 UBTF lung cancer 28806394
ENSG00000108312 UBTF tumor 28846478
ENSG00000108312 UBTF lung cancer 30250529
ENSG00000108312 UBTF cancer 31504794
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108312 UBTF MESO 0.024 low
ENSG00000108312 UBTF STAD 0.05 low
ENSG00000108312 UBTF UVM 0.022 high
ENSG00000108312 UBTF PAAD 0.011 low
ENSG00000108312 UBTF UCEC 0.0054 low
ENSG00000108312 UBTF THCA 0.0039 low
ENSG00000108312 UBTF ACC 0.03 high
ENSG00000108312 UBTF LGG 8e-04 low
ENSG00000108312 UBTF HNSC 0.0087 low
ENSG00000108312 UBTF READ 0.003 high
ENSG00000108312 UBTF THYM 0.0013 low
ENSG00000108312 UBTF BRCA 0.00062 low
ENSG00000108312 UBTF ESCA 0.02 low
ENSG00000108312 UBTF LAML 0.011 high
ENSG00000108312 UBTF SKCM 0.015 low
ENSG00000108312 UBTF CESC 0.0025 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108312 UBTF ACC Del 1.372354 0.125106 0.565041 0.277778
ENSG00000108312 UBTF PCPG Amp 2.988068 0.109449 0.748138 0.098765
ENSG00000108312 UBTF PCPG Del 2.929986 0.100914 0.623071 0.166667
ENSG00000108312 UBTF BRCA Del 6.760343 0.101148 0.432134 0.338889
ENSG00000108312 UBTF PRAD Del 14.153581 0.173400 0.480373 0.195122
ENSG00000108312 UBTF UCEC Del 3.486544 0.076730 0.569458 0.192950