Ensembl ID ENSG00000108055 Gene ID 9126 Accession 2468
Gene Symbol SMC3 Alias BAM;BMH;HCAP;CDLS3;CSPG6;SMC3L1 Full Name structural maintenance of chromosomes 3
Position 10 : 110567695 - 110606048 Length 38354 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

ENSG00000108055 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108055 SMC3 intestinal tumors 10801778
ENSG00000108055 SMC3 cancer 12381310
ENSG00000108055 SMC3 tumors 12579853
ENSG00000108055 SMC3 prostate cancer 12672042
ENSG00000108055 SMC3 tumor 1560787
ENSG00000108055 SMC3 cancer 16495932
ENSG00000108055 SMC3 bladder cancer 16740760
ENSG00000108055 SMC3 tumour 18332853
ENSG00000108055 SMC3 prostate cancer 18594538
ENSG00000108055 SMC3 cancer 19509265
ENSG00000108055 SMC3 cancer 19739098
ENSG00000108055 SMC3 cancer 20501661
ENSG00000108055 SMC3 cancer 20862547
ENSG00000108055 SMC3 tumor 22237025
ENSG00000108055 SMC3 breast cancer 22913342
ENSG00000108055 SMC3 tumor 22949172
ENSG00000108055 SMC3 tumor 23424670
ENSG00000108055 SMC3 tumor 23642077
ENSG00000108055 SMC3 tumor 24250782
ENSG00000108055 SMC3 cancer 24281554
ENSG00000108055 SMC3 AML 24335498
ENSG00000108055 SMC3 tumor 24454822
ENSG00000108055 SMC3 tumour 24741438
ENSG00000108055 SMC3 cancer 24802800
ENSG00000108055 SMC3 AML 24856830
ENSG00000108055 SMC3 tumor 25405470
ENSG00000108055 SMC3 tumour 2541906
ENSG00000108055 SMC3 Cancer 25803690
ENSG00000108055 SMC3 tumors 25984700
ENSG00000108055 SMC3 tumor 26306458
ENSG00000108055 SMC3 Wilms tumor 26315090
ENSG00000108055 SMC3 tumor 26381235
ENSG00000108055 SMC3 tumor 26388236
ENSG00000108055 SMC3 tumor 26416038
ENSG00000108055 SMC3 tumor 26823374
ENSG00000108055 SMC3 tumors 26871722
ENSG00000108055 SMC3 Cancer 27072133
ENSG00000108055 SMC3 lung cancer 27153727
ENSG00000108055 SMC3 tumor 27270079
ENSG00000108055 SMC3 cancer 27307603
ENSG00000108055 SMC3 AML 27470916
ENSG00000108055 SMC3 breast cancer 27788220
ENSG00000108055 SMC3 tumor 27980218
ENSG00000108055 SMC3 tumor 28132024
ENSG00000108055 SMC3 AML 28152414
ENSG00000108055 SMC3 GBM 28368610
ENSG00000108055 SMC3 cancer 28480257
ENSG00000108055 SMC3 bladder cancer 29207682
ENSG00000108055 SMC3 tumor 29267927
ENSG00000108055 SMC3 AML 29270125
ENSG00000108055 SMC3 cancer 29312880
ENSG00000108055 SMC3 tumour 29385983
ENSG00000108055 SMC3 tumors 29590101
ENSG00000108055 SMC3 tumor 29617669
ENSG00000108055 SMC3 tumor 2983106
ENSG00000108055 SMC3 lung cancer 29852353
ENSG00000108055 SMC3 tumor 30161165
ENSG00000108055 SMC3 cancer 30451133
ENSG00000108055 SMC3 cancer 30538563
ENSG00000108055 SMC3 acute myeloid leukemia (AML) 30553776
ENSG00000108055 SMC3 AML 30630974
ENSG00000108055 SMC3 AML 30669675
ENSG00000108055 SMC3 cancers 30873408
ENSG00000108055 SMC3 cancer 30975996
ENSG00000108055 SMC3 tumors 31083581
ENSG00000108055 SMC3 tumor 31271967
ENSG00000108055 SMC3 tumors 31275557
ENSG00000108055 SMC3 tumor 31479687
ENSG00000108055 SMC3 bone cancer 31515677
ENSG00000108055 SMC3 tumor 7520508
ENSG00000108055 SMC3 tumor 7907632
ENSG00000108055 SMC3 tumors 7913843
ENSG00000108055 SMC3 tumor 8621634
ENSG00000108055 SMC3 tumor 8701742
ENSG00000108055 SMC3 lung cancer 9364212
ENSG00000108055 SMC3 pituitary tumor 9819799
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108055 SMC3 MESO 0.048 high
ENSG00000108055 SMC3 PAAD 0.029 high
ENSG00000108055 SMC3 UCEC 0.026 low
ENSG00000108055 SMC3 HNSC 0.0011 low
ENSG00000108055 SMC3 READ 0.042 low
ENSG00000108055 SMC3 KIRP 0.0018 high
ENSG00000108055 SMC3 KICH 0.021 high
ENSG00000108055 SMC3 LUAD 0.048 high
ENSG00000108055 SMC3 PCPG 0.018 high
ENSG00000108055 SMC3 COAD 0.049 high
ENSG00000108055 SMC3 UCS 0.045 low
ENSG00000108055 SMC3 ESCA 0.0017 high
ENSG00000108055 SMC3 OV 0.039 high
ENSG00000108055 SMC3 PRAD 0.0049 high
ENSG00000108055 SMC3 GBM 0.028 low
ENSG00000108055 SMC3 CESC 0.028 low
ENSG00000108055 SMC3 LIHC 0.0069 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108055 SMC3 CHOL Del 0.773813 0.210515 0.458947 0.250000
ENSG00000108055 SMC3 LUSC Del 0.897168 0.068503 0.355385 0.512974
ENSG00000108055 SMC3 LGG Del 7.420679 0.089904 0.582458 0.245614
ENSG00000108055 SMC3 CESC Del 0.868728 0.070464 0.441995 0.298305
ENSG00000108055 SMC3 READ Del 0.637830 0.068896 0.405050 0.290909
ENSG00000108055 SMC3 COAD Del 3.211192 0.066975 0.350571 0.228381
ENSG00000108055 SMC3 GBM Del 1.163784 0.057979 0.697445 0.882149
ENSG00000108055 SMC3 LIHC Del 2.764010 0.095683 0.491917 0.272973
ENSG00000108055 SMC3 BLCA Del 1.932333 0.097385 0.395427 0.419118
ENSG00000108055 SMC3 BRCA Del 7.217330 0.103253 0.390079 0.305556
ENSG00000108055 SMC3 STAD Del 1.266767 0.068740 0.351187 0.208617
ENSG00000108055 SMC3 UCEC Del 2.824935 0.070905 0.539450 0.120594
ENSG00000108055 SMC3 MESO Del 2.679214 0.200352 0.485373 0.356322
ENSG00000108055 SMC3 OV Del 4.308871 0.237846 0.523139 0.360967