Ensembl ID ENSG00000108010 Gene ID 10539 Accession 15987
Gene Symbol GLRX3 Alias GRX3;GRX4;GLRX4;PICOT;TXNL2;TXNL3 Full Name glutaredoxin 3
Position 10 : 130136391 - 130184521 Length 48131 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

ENSG00000108010 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000108010 GLRX3 0.33 1.24e-11 BRCA
ENSG00000108010 GLRX3 0.83 3.50e-20 COAD
ENSG00000108010 GLRX3 1.33 9.00e-39 LUSC
ENSG00000108010 GLRX3 0.63 3.92e-11 UCEC
ENSG00000108010 GLRX3 0.84 5.95e-22 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000108010 GLRX3 tumour 18644147
ENSG00000108010 GLRX3 breast cancer 21123948
ENSG00000108010 GLRX3 cancer 22309771
ENSG00000108010 GLRX3 cancer 25928219
ENSG00000108010 GLRX3 cancer 25975981
ENSG00000108010 GLRX3 breast cancer 26218761
ENSG00000108010 GLRX3 tumors 27203742
ENSG00000108010 GLRX3 Cancer 29317492
ENSG00000108010 GLRX3 cancer 29397791
ENSG00000108010 GLRX3 breast cancer 29628988
ENSG00000108010 GLRX3 lung cancer 29860757
ENSG00000108010 GLRX3 cancer 30489196
ENSG00000108010 GLRX3 tumor 30661989
ENSG00000108010 GLRX3 cancers 31527584
ENSG00000108010 GLRX3 tumor 31583069
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000108010 GLRX3 MESO 0.0034 high
ENSG00000108010 GLRX3 SARC 0.0065 high
ENSG00000108010 GLRX3 CHOL 0.019 high
ENSG00000108010 GLRX3 PAAD 0.0076 high
ENSG00000108010 GLRX3 UCEC 0.0049 high
ENSG00000108010 GLRX3 LUSC 0.00078 low
ENSG00000108010 GLRX3 HNSC 0.0065 high
ENSG00000108010 GLRX3 KIRP 0.0022 high
ENSG00000108010 GLRX3 KICH 0.048 high
ENSG00000108010 GLRX3 LUAD 0.017 high
ENSG00000108010 GLRX3 PCPG 0.00043 high
ENSG00000108010 GLRX3 BRCA 0.0092 high
ENSG00000108010 GLRX3 COAD 0.012 low
ENSG00000108010 GLRX3 UCS 0.022 low
ENSG00000108010 GLRX3 ESCA 0.016 high
ENSG00000108010 GLRX3 OV 0.047 low
ENSG00000108010 GLRX3 PRAD 0.001 high
ENSG00000108010 GLRX3 SKCM 0.0037 low
ENSG00000108010 GLRX3 CESC 0.042 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000108010 GLRX3 LUSC Del 1.003687 0.070232 0.354164 0.495010
ENSG00000108010 GLRX3 LUAD Del 0.777968 0.052244 0.302508 0.288760
ENSG00000108010 GLRX3 LGG Del 16.182175 0.135490 0.572848 0.294347
ENSG00000108010 GLRX3 COAD Del 1.576480 0.052092 0.347803 0.226164
ENSG00000108010 GLRX3 THYM Del 0.970980 0.045771 0.635036 0.048780
ENSG00000108010 GLRX3 GBM Del 1.911966 0.066423 0.700539 0.897747
ENSG00000108010 GLRX3 LIHC Del 4.080830 0.111484 0.497115 0.286486
ENSG00000108010 GLRX3 TGCT Del 0.606945 0.053411 0.372802 0.473333
ENSG00000108010 GLRX3 BLCA Del 1.221739 0.086241 0.396054 0.392157
ENSG00000108010 GLRX3 BRCA Del 9.585088 0.113177 0.409673 0.285185
ENSG00000108010 GLRX3 STAD Del 1.591286 0.073404 0.337747 0.195011
ENSG00000108010 GLRX3 UCEC Del 1.199805 0.054434 0.502048 0.109462
ENSG00000108010 GLRX3 MESO Del 1.185966 0.144353 0.481010 0.310345
ENSG00000108010 GLRX3 OV Del 2.445277 0.210359 0.512836 0.324698