Ensembl ID ENSG00000107937 Gene ID 23560 Accession 21535
Gene Symbol GTPBP4 Alias NGB;CRFG;NOG1 Full Name GTP binding protein 4
Position 10 : 988434 - 1019932 Length 31499 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

ENSG00000107937 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000107937 GTPBP4 0.67 5.07e-23 BRCA
ENSG00000107937 GTPBP4 1.10 2.63e-71 COAD
ENSG00000107937 GTPBP4 0.90 1.85e-11 READ
ENSG00000107937 GTPBP4 0.89 7.68e-26 LUSC
ENSG00000107937 GTPBP4 1.02 3.78e-23 STAD
ENSG00000107937 GTPBP4 0.66 3.39e-14 UCEC
ENSG00000107937 GTPBP4 0.78 5.67e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000107937 GTPBP4 cancer 20308539
ENSG00000107937 GTPBP4 tumor 27720713
ENSG00000107937 GTPBP4 tumors 29212203
ENSG00000107937 GTPBP4 Gastric Cancer 29408813
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000107937 GTPBP4 SARC 0.00059 high
ENSG00000107937 GTPBP4 UVM 0.029 high
ENSG00000107937 GTPBP4 UCEC 0.00035 high
ENSG00000107937 GTPBP4 THCA 0.032 high
ENSG00000107937 GTPBP4 HNSC 0.0055 high
ENSG00000107937 GTPBP4 READ 0.012 low
ENSG00000107937 GTPBP4 KICH 0.049 high
ENSG00000107937 GTPBP4 LUAD 0.026 high
ENSG00000107937 GTPBP4 THYM 0.049 low
ENSG00000107937 GTPBP4 BRCA 0.00099 high
ENSG00000107937 GTPBP4 COAD 0.0046 high
ENSG00000107937 GTPBP4 OV 0.0024 low
ENSG00000107937 GTPBP4 DLBC 0.034 low
ENSG00000107937 GTPBP4 KIRC 0.0033 high
ENSG00000107937 GTPBP4 PRAD 0.041 low
ENSG00000107937 GTPBP4 BLCA 0.023 high
ENSG00000107937 GTPBP4 LAML 0.027 high
ENSG00000107937 GTPBP4 GBM 0.0048 low
ENSG00000107937 GTPBP4 CESC 0.0043 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000107937 GTPBP4 LUSC Del 3.722108 0.101350 0.378106 0.447106
ENSG00000107937 GTPBP4 LUAD Del 3.494676 0.081199 0.332194 0.246124
ENSG00000107937 GTPBP4 LGG Amp 4.107918 0.089359 0.739392 0.132554
ENSG00000107937 GTPBP4 SARC Del 2.840734 0.176089 0.586345 0.474708
ENSG00000107937 GTPBP4 GBM Del 3.108818 0.077681 0.691759 0.814558
ENSG00000107937 GTPBP4 PAAD Del 0.762851 0.046483 0.364824 0.222826
ENSG00000107937 GTPBP4 HNSC Del 1.379888 0.062221 0.375708 0.325670
ENSG00000107937 GTPBP4 BLCA Amp 3.241985 0.245913 0.570141 0.404412
ENSG00000107937 GTPBP4 BRCA Amp 1.888530 0.168272 0.607405 0.269444
ENSG00000107937 GTPBP4 STAD Del 0.744982 0.061129 0.395374 0.172336
ENSG00000107937 GTPBP4 MESO Del 2.393645 0.190397 0.526301 0.321839
ENSG00000107937 GTPBP4 OV Amp 3.099185 0.405699 0.763527 0.435233