Ensembl ID ENSG00000107290 Gene ID 23064 Accession 445
Gene Symbol SETX Alias ALS4;AOA2;STEX;Sen1;SCAN2;SCAR1;bA479K20.2 Full Name senataxin
Position 9 : 132261356 - 132354986 Length 93631 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]

ENSG00000107290 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000107290 SETX -0.3 5.05e-12 BRCA
ENSG00000107290 SETX -0.6 2.52e-16 LUSC
ENSG00000107290 SETX -0.4 9.91e-12 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000107290 SETX tumor 21108794
ENSG00000107290 SETX breast cancer 25699710
ENSG00000107290 SETX tumor 28977923
ENSG00000107290 SETX Lung Cancer 30419062
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000107290 SETX MESO 0.024 low
ENSG00000107290 SETX CHOL 0.0077 low
ENSG00000107290 SETX THCA 0.0063 high
ENSG00000107290 SETX ACC 0.00013 high
ENSG00000107290 SETX LGG 0.0069 high
ENSG00000107290 SETX LUSC 0.019 high
ENSG00000107290 SETX HNSC 0.019 low
ENSG00000107290 SETX READ 0.0056 low
ENSG00000107290 SETX LUAD 0.048 low
ENSG00000107290 SETX THYM 0.0027 low
ENSG00000107290 SETX UCS 0.00074 high
ENSG00000107290 SETX OV 0.008 high
ENSG00000107290 SETX DLBC 0.036 high
ENSG00000107290 SETX GBM 0.023 low
ENSG00000107290 SETX SKCM 0.00034 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000107290 SETX SARC Del 1.409870 0.142387 0.513377 0.233463
ENSG00000107290 SETX UCEC Del 1.135360 0.053630 0.539310 0.241187
ENSG00000107290 SETX OV Del 4.999902 0.246635 0.571669 0.583765