Ensembl ID ENSG00000106615 Gene ID 6009 Accession 10011
Gene Symbol RHEB Alias RHEB2 Full Name Ras homolog, mTORC1 binding
Position 7 : 151466012 - 151520120 Length 54109 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

ENSG00000106615 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000106615 0.60 1.73e-13 COAD
ENSG00000106615 0.54 8.03e-15 LIHC
ENSG00000106615 0.62 5.48e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000106615 breast cancer 18324915
ENSG00000106615 tumors 18538015
ENSG00000106615 bladder tumors 19789314
ENSG00000106615 Cancer 20161818
ENSG00000106615 cancer 20388784
ENSG00000106615 tumors 20616807
ENSG00000106615 cancers 21655954
ENSG00000106615 Tumors of the Breast 23110024
ENSG00000106615 tumor 24762440
ENSG00000106615 tumors 25904681
ENSG00000106615 cancer 26137524
ENSG00000106615 cancer 26255626
ENSG00000106615 colon cancer 27998790
ENSG00000106615 tumor 29050215
ENSG00000106615 Cancer 29236692
ENSG00000106615 cancer 29320991
ENSG00000106615 liver cancer 29467900
ENSG00000106615 cancer 30262562
ENSG00000106615 tumor 30558189
ENSG00000106615 tumor 31154896
ENSG00000106615 tumor 31157168
ENSG00000106615 colorectal cancer 31332784
ENSG00000106615 cancer 31488423
ENSG00000106615 colorectal cancer 31515468
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000106615 MESO 0.0042 high
ENSG00000106615 PAAD 0.0015 high
ENSG00000106615 ACC 0.00079 high
ENSG00000106615 HNSC 0.0024 high
ENSG00000106615 KICH 0.00017 high
ENSG00000106615 LUAD 0.038 low
ENSG00000106615 BRCA 0.0094 high
ENSG00000106615 UCS 0.026 high
ENSG00000106615 ESCA 0.034 high
ENSG00000106615 OV 0.01 low
ENSG00000106615 DLBC 0.035 low
ENSG00000106615 PRAD 0.0059 low
ENSG00000106615 LAML 0.0028 low
ENSG00000106615 GBM 0.018 high
ENSG00000106615 SKCM 0.00082 high
ENSG00000106615 CESC 0.018 high
ENSG00000106615 LIHC 0.00011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000106615 LUSC Del 2.199644 0.085575 0.359228 0.179641
ENSG00000106615 LAML Del 2.810899 0.058384 0.719663 0.130890
ENSG00000106615 LUAD Amp 0.895462 0.122322 0.425230 0.436047
ENSG00000106615 LGG Amp 5.282026 0.102962 0.670397 0.341131
ENSG00000106615 CESC Del 1.633538 0.085144 0.482562 0.203390
ENSG00000106615 UCS Del 0.664239 0.199130 0.456551 0.321429
ENSG00000106615 SARC Del 1.903103 0.155025 0.535709 0.229572
ENSG00000106615 PAAD Del 0.952334 0.051191 0.380819 0.081522
ENSG00000106615 ESCA Del 7.693213 0.244773 0.446139 0.342391
ENSG00000106615 SKCM Amp 3.972537 0.216844 0.715484 0.585831
ENSG00000106615 HNSC Del 20.508295 0.174220 0.416720 0.250958
ENSG00000106615 BRCA Del 2.387029 0.077389 0.424271 0.172222
ENSG00000106615 STAD Del 4.158570 0.100900 0.363250 0.199546
ENSG00000106615 UCEC Del 1.421563 0.057246 0.493058 0.111317
ENSG00000106615 OV Amp 10.735492 0.559475 0.753012 0.531952