Ensembl ID ENSG00000106211 Gene ID 3315 Accession 5246
Gene Symbol HSPB1 Alias CMT2F;HMN2B;HSP27;HSP28;Hsp25;SRP27;HS.76067;HEL-S-102 Full Name heat shock protein family B (small) member 1
Position 7 : 76302673 - 76304295 Length 1623 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

ENSG00000106211 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000106211 HSPB1 0.82 7.63e-12 KIRC
ENSG00000106211 HSPB1 1.52 3.10e-34 BRCA
ENSG00000106211 HSPB1 1.33 2.77e-15 KICH
ENSG00000106211 HSPB1 2.04 4.38e-43 LUSC
ENSG00000106211 HSPB1 1.53 2.41e-21 KIRP
ENSG00000106211 HSPB1 1.64 1.02e-25 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000106211 HSPB1 ovarian cancer 10226541
ENSG00000106211 HSPB1 tumour 10356405
ENSG00000106211 HSPB1 tumors 10861421
ENSG00000106211 HSPB1 tumours 11078920
ENSG00000106211 HSPB1 tumor 11429196
ENSG00000106211 HSPB1 tumors 11849747
ENSG00000106211 HSPB1 tumor 1313743
ENSG00000106211 HSPB1 lung cancer 14688473
ENSG00000106211 HSPB1 tumors 15351573
ENSG00000106211 HSPB1 breast cancer 15833836
ENSG00000106211 HSPB1 tumor 16648970
ENSG00000106211 HSPB1 tumor 16696328
ENSG00000106211 HSPB1 tumour 16720063
ENSG00000106211 HSPB1 AML 17693191
ENSG00000106211 HSPB1 tumors 17883861
ENSG00000106211 HSPB1 tumor 19189670
ENSG00000106211 HSPB1 gastric cancer 19203381
ENSG00000106211 HSPB1 cancer 19367286
ENSG00000106211 HSPB1 trophoblastic tumor 19575256
ENSG00000106211 HSPB1 tumors 19643972
ENSG00000106211 HSPB1 prostate cancer 19707199
ENSG00000106211 HSPB1 cancer 20145720
ENSG00000106211 HSPB1 lung cancer 20231684
ENSG00000106211 HSPB1 tumour 20702176
ENSG00000106211 HSPB1 cancer 21113302
ENSG00000106211 HSPB1 tumour 21114636
ENSG00000106211 HSPB1 cancers 21225769
ENSG00000106211 HSPB1 cancer 21225770
ENSG00000106211 HSPB1 cancer 21423207
ENSG00000106211 HSPB1 GBM 21470419
ENSG00000106211 HSPB1 pancreatic cancer 21833720
ENSG00000106211 HSPB1 non-small-cell lung cancer 21937138
ENSG00000106211 HSPB1 tumour 21961414
ENSG00000106211 HSPB1 colorectal cancer 21989268
ENSG00000106211 HSPB1 tumors 22083493
ENSG00000106211 HSPB1 tumor 22350794
ENSG00000106211 HSPB1 breast cancer 22384035
ENSG00000106211 HSPB1 tumors 22452810
ENSG00000106211 HSPB1 lung cancer 22500095
ENSG00000106211 HSPB1 colorectal cancer 22515340
ENSG00000106211 HSPB1 tumor 22539317
ENSG00000106211 HSPB1 non-small cell lung cancer 22608953
ENSG00000106211 HSPB1 tumour 22627320
ENSG00000106211 HSPB1 cancer 22683760
ENSG00000106211 HSPB1 colorectal cancer 22799385
ENSG00000106211 HSPB1 cancer 22804237
ENSG00000106211 HSPB1 cancer 22804238
ENSG00000106211 HSPB1 gastric cancer 22860099
ENSG00000106211 HSPB1 breast cancer 22907762
ENSG00000106211 HSPB1 cancer 22984562
ENSG00000106211 HSPB1 cancer 22989709
ENSG00000106211 HSPB1 prostate cancer 23165430
ENSG00000106211 HSPB1 cancer 23227181
ENSG00000106211 HSPB1 nerve sheath tumours 23348018
ENSG00000106211 HSPB1 non-small cell lung cancer 23374503
ENSG00000106211 HSPB1 oral cancer 23453029
ENSG00000106211 HSPB1 prostate cancer 23492367
ENSG00000106211 HSPB1 cancer 23530261
ENSG00000106211 HSPB1 tumor 24078811
ENSG00000106211 HSPB1 tumour 24143227
ENSG00000106211 HSPB1 pancreatic cancer 24175808
ENSG00000106211 HSPB1 cancer 24213112
ENSG00000106211 HSPB1 tumor 24222130
ENSG00000106211 HSPB1 cancer 24278676
ENSG00000106211 HSPB1 breast cancer 24307543
ENSG00000106211 HSPB1 Tumor 24465581
ENSG00000106211 HSPB1 Cancers 24514166
ENSG00000106211 HSPB1 tumour 24569473
ENSG00000106211 HSPB1 tumor 24812703
ENSG00000106211 HSPB1 GBM 24838487
ENSG00000106211 HSPB1 gastric cancer 24903273
ENSG00000106211 HSPB1 prostate cancer 24982356
ENSG00000106211 HSPB1 cancer 25126737
ENSG00000106211 HSPB1 prostate cancer 25193387
ENSG00000106211 HSPB1 cancer 25392686
ENSG00000106211 HSPB1 breast cancer 25454514
ENSG00000106211 HSPB1 breast cancer 25519015
ENSG00000106211 HSPB1 breast cancer 25541910
ENSG00000106211 HSPB1 cancer 25728673
ENSG00000106211 HSPB1 Lung Cancer 25811031
ENSG00000106211 HSPB1 tumours 25980435
ENSG00000106211 HSPB1 tumor 26108672
ENSG00000106211 HSPB1 tumor 26158290
ENSG00000106211 HSPB1 tumor 26305875
ENSG00000106211 HSPB1 prostate cancer 26434601
ENSG00000106211 HSPB1 cancer 26675522
ENSG00000106211 HSPB1 cancer 26744531
ENSG00000106211 HSPB1 Pancreatic Cancer 26805817
ENSG00000106211 HSPB1 Breast Cancer 26847234
ENSG00000106211 HSPB1 lung cancer 26874728
ENSG00000106211 HSPB1 tumor 27351523
ENSG00000106211 HSPB1 Ovarian Cancer 27354589
ENSG00000106211 HSPB1 cancer 27449291
ENSG00000106211 HSPB1 cancer 27555231
ENSG00000106211 HSPB1 cancer 27626679
ENSG00000106211 HSPB1 prostate cancer 27708246
ENSG00000106211 HSPB1 cervical cancer 27860262
ENSG00000106211 HSPB1 cervical cancer 28337643
ENSG00000106211 HSPB1 tumors 28468249
ENSG00000106211 HSPB1 tumor 28608263
ENSG00000106211 HSPB1 cancer 28754978
ENSG00000106211 HSPB1 ovarian cancer 28857608
ENSG00000106211 HSPB1 colorectal cancer 28903393
ENSG00000106211 HSPB1 tumors 28918740
ENSG00000106211 HSPB1 non-small cell lung cancer 29017331
ENSG00000106211 HSPB1 cancer 29285257
ENSG00000106211 HSPB1 tumor 29332450
ENSG00000106211 HSPB1 tumor 29502008
ENSG00000106211 HSPB1 cancer 29650953
ENSG00000106211 HSPB1 cancers 29753870
ENSG00000106211 HSPB1 tumours 29954368
ENSG00000106211 HSPB1 tumor 29966326
ENSG00000106211 HSPB1 thyroid cancer 29997231
ENSG00000106211 HSPB1 HNSCC 30157864
ENSG00000106211 HSPB1 tumor 30344796
ENSG00000106211 HSPB1 metastatic tumor 30396985
ENSG00000106211 HSPB1 cervical cancer 30696738
ENSG00000106211 HSPB1 lung cancer 31015126
ENSG00000106211 HSPB1 lung cancer 31015163
ENSG00000106211 HSPB1 Cancer 31139280
ENSG00000106211 HSPB1 tumor 31364192
ENSG00000106211 HSPB1 prostate cancer 31428571
ENSG00000106211 HSPB1 cancers 31533245
ENSG00000106211 HSPB1 cancer 31573509
ENSG00000106211 HSPB1 cancer 31612776
ENSG00000106211 HSPB1 cancer 31749945
ENSG00000106211 HSPB1 tumors 31897148
ENSG00000106211 HSPB1 breast cancer 7579511
ENSG00000106211 HSPB1 tumour 7669571
ENSG00000106211 HSPB1 tumor 7777477
ENSG00000106211 HSPB1 Cancer 7845389
ENSG00000106211 HSPB1 tumor 8188614
ENSG00000106211 HSPB1 tumors 8852447
ENSG00000106211 HSPB1 head and neck cancer 9060543
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000106211 HSPB1 MESO 0.014 high
ENSG00000106211 HSPB1 UVM 0.014 low
ENSG00000106211 HSPB1 PAAD 0.0073 high
ENSG00000106211 HSPB1 UCEC 0.0069 low
ENSG00000106211 HSPB1 ACC 0.0012 low
ENSG00000106211 HSPB1 HNSC 0.007 low
ENSG00000106211 HSPB1 READ 0.00043 high
ENSG00000106211 HSPB1 KICH 0.00082 low
ENSG00000106211 HSPB1 LUAD 0.028 high
ENSG00000106211 HSPB1 PCPG 0.02 low
ENSG00000106211 HSPB1 COAD 0.0072 high
ENSG00000106211 HSPB1 KIRC 7e-04 high
ENSG00000106211 HSPB1 LAML 0.0036 high
ENSG00000106211 HSPB1 GBM 0.0011 high
ENSG00000106211 HSPB1 SKCM 3e-04 high
ENSG00000106211 HSPB1 LIHC 0.0044 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency