Ensembl ID ENSG00000106105 Gene ID 2617 Accession 4162
Gene Symbol GARS1 Alias GARS;HMN5;CMT2D;DSMAV;GlyRS;HMN5A;SMAD1;SMAJI Full Name glycyl-tRNA synthetase 1
Position 7 : 30580533 - 30634033 Length 53501 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

ENSG00000106105 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000106105 GARS 0.90 1.16e-47 BRCA
ENSG00000106105 GARS 1.22 1.41e-54 COAD
ENSG00000106105 GARS 1.22 1.73e-21 KICH
ENSG00000106105 GARS 1.13 9.42e-14 READ
ENSG00000106105 GARS 1.17 4.56e-41 LUSC
ENSG00000106105 GARS 0.48 3.21e-15 PRAD
ENSG00000106105 GARS 0.59 5.36e-11 LIHC
ENSG00000106105 GARS 0.96 1.89e-23 UCEC
ENSG00000106105 GARS 1.05 2.70e-34 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000106105 GARS cancers 12538453
ENSG00000106105 GARS breast cancer 20872419
ENSG00000106105 GARS tumor 22345558
ENSG00000106105 GARS tumor 22370639
ENSG00000106105 GARS cancer 22952576
ENSG00000106105 GARS tumour 23427196
ENSG00000106105 GARS cancer 27348078
ENSG00000106105 GARS tumor 28105238
ENSG00000106105 GARS tumor 30477734
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000106105 GARS MESO 0.0011 high
ENSG00000106105 GARS SARC 0.0053 high
ENSG00000106105 GARS UVM 0.00024 high
ENSG00000106105 GARS UCEC 0.00053 high
ENSG00000106105 GARS THCA 0.043 low
ENSG00000106105 GARS ACC 0.00032 high
ENSG00000106105 GARS LUSC 0.014 low
ENSG00000106105 GARS HNSC 0.0011 high
ENSG00000106105 GARS READ 0.0095 low
ENSG00000106105 GARS KICH 0.00018 high
ENSG00000106105 GARS LUAD 0.00059 high
ENSG00000106105 GARS BRCA 0.00019 high
ENSG00000106105 GARS COAD 0.0099 high
ENSG00000106105 GARS UCS 0.021 high
ENSG00000106105 GARS ESCA 0.0084 high
ENSG00000106105 GARS OV 0.015 low
ENSG00000106105 GARS DLBC 0.023 low
ENSG00000106105 GARS PRAD 0.01 low
ENSG00000106105 GARS TGCT 0.033 low
ENSG00000106105 GARS CESC 0.019 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000106105 GARS PRAD Amp 1.326562 0.055063 0.527750 0.215447