Ensembl ID ENSG00000105202 Gene ID 2091 Accession 3599
Gene Symbol FBL Alias FIB;FLRN;Nop1;RNU3IP1 Full Name fibrillarin
Position 19 : 39834458 - 39846379 Length 11922 bases Strand Minus strand
Status Confidence Main interacting RNAssnoRNARBP type Canonical_RBPs
Summary This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

ENSG00000105202 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000105202 FBL 0.81 7.55e-32 KIRC
ENSG00000105202 FBL 1.10 6.96e-21 COAD
ENSG00000105202 FBL 1.63 3.53e-44 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000105202 FBL tumor 11160355
ENSG00000105202 FBL tumor 11243109
ENSG00000105202 FBL tumor 1184239
ENSG00000105202 FBL tumor 12045239
ENSG00000105202 FBL tumor 12456594
ENSG00000105202 FBL tumor 1374106
ENSG00000105202 FBL tumor 15625761
ENSG00000105202 FBL tumor 1674958
ENSG00000105202 FBL tumor 1698639
ENSG00000105202 FBL breast cancer 17022634
ENSG00000105202 FBL tumor 170343
ENSG00000105202 FBL tumor 1705514
ENSG00000105202 FBL DLBCL 17617899
ENSG00000105202 FBL tumors 182645
ENSG00000105202 FBL tumors 18851746
ENSG00000105202 FBL cancer 20025723
ENSG00000105202 FBL DLBCL 20046882
ENSG00000105202 FBL cancer 20428803
ENSG00000105202 FBL prostate cancer 21435462
ENSG00000105202 FBL tumor 2144789
ENSG00000105202 FBL tumor 21761245
ENSG00000105202 FBL tumor 22890822
ENSG00000105202 FBL Tumor 23028784
ENSG00000105202 FBL breast cancer 23542174
ENSG00000105202 FBL cancer 24029231
ENSG00000105202 FBL tumor 2411817
ENSG00000105202 FBL tumor 2420893
ENSG00000105202 FBL tumor 2422280
ENSG00000105202 FBL tumor 2459230
ENSG00000105202 FBL tumor 24782871
ENSG00000105202 FBL tumor 2479634
ENSG00000105202 FBL tumor 2483152
ENSG00000105202 FBL tumor 25343644
ENSG00000105202 FBL tumor 2562982
ENSG00000105202 FBL tumor 2582053
ENSG00000105202 FBL tumor 26608920
ENSG00000105202 FBL AML 28103300
ENSG00000105202 FBL tumor 29194477
ENSG00000105202 FBL breast cancer 29674660
ENSG00000105202 FBL tumor 29951052
ENSG00000105202 FBL tumor 30292240
ENSG00000105202 FBL breast cancer 30501594
ENSG00000105202 FBL tumor 30635687
ENSG00000105202 FBL cancers 30764532
ENSG00000105202 FBL cancer 31026227
ENSG00000105202 FBL tumor 3108381
ENSG00000105202 FBL tumor 31396485
ENSG00000105202 FBL tumor 3485134
ENSG00000105202 FBL tumor 3491145
ENSG00000105202 FBL tumor 3881168
ENSG00000105202 FBL tumor 3921652
ENSG00000105202 FBL tumor 54387
ENSG00000105202 FBL tumor 54388
ENSG00000105202 FBL tumor 54438
ENSG00000105202 FBL tumors 56223
ENSG00000105202 FBL tumor 58034
ENSG00000105202 FBL tumor 6214653
ENSG00000105202 FBL tumor 6218125
ENSG00000105202 FBL tumor 6389777
ENSG00000105202 FBL breast cancer 6539160
ENSG00000105202 FBL tumor 6604036
ENSG00000105202 FBL tumors 6607955
ENSG00000105202 FBL tumor 6608405
ENSG00000105202 FBL tumor 6609266
ENSG00000105202 FBL tumor 6942187
ENSG00000105202 FBL tumor 6980254
ENSG00000105202 FBL tumor 6980314
ENSG00000105202 FBL tumor 7474084
ENSG00000105202 FBL tumor 7499022
ENSG00000105202 FBL tumor 7525983
ENSG00000105202 FBL tumor 7687300
ENSG00000105202 FBL tumor 7911123
ENSG00000105202 FBL tumor 7916205
ENSG00000105202 FBL tumor 7930583
ENSG00000105202 FBL tumor 8176202
ENSG00000105202 FBL tumor 8313363
ENSG00000105202 FBL tumor 833881
ENSG00000105202 FBL tumor 8496592
ENSG00000105202 FBL tumor 8496686
ENSG00000105202 FBL tumor 8697988
ENSG00000105202 FBL tumors 8892898
ENSG00000105202 FBL tumor 9480979
ENSG00000105202 FBL tumor 953995
ENSG00000105202 FBL tumor 9719100
ENSG00000105202 FBL tumor 9820528
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000105202 FBL MESO 0.0015 high
ENSG00000105202 FBL SARC 8e-04 high
ENSG00000105202 FBL STAD 0.029 low
ENSG00000105202 FBL CHOL 0.033 low
ENSG00000105202 FBL UVM 0.0011 low
ENSG00000105202 FBL UCEC 0.018 low
ENSG00000105202 FBL THCA 0.035 low
ENSG00000105202 FBL LUSC 0.034 low
ENSG00000105202 FBL READ 0.013 low
ENSG00000105202 FBL KIRP 0.0025 high
ENSG00000105202 FBL LUAD 0.0032 high
ENSG00000105202 FBL THYM 0.011 low
ENSG00000105202 FBL BRCA 0.00025 low
ENSG00000105202 FBL UCS 0.047 low
ENSG00000105202 FBL DLBC 0.015 low
ENSG00000105202 FBL GBM 0.0058 low
ENSG00000105202 FBL SKCM 0.00057 high
ENSG00000105202 FBL LIHC 0.00041 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000105202 FBL LUSC Amp 14.897539 0.475289 0.730497 0.431138
ENSG00000105202 FBL LUAD Amp 2.763548 0.164753 0.460493 0.251938
ENSG00000105202 FBL LGG Del 2.506948 0.056771 0.664058 0.442495
ENSG00000105202 FBL CESC Amp 3.463617 0.224677 0.714630 0.311864
ENSG00000105202 FBL COAD Amp 0.778838 0.068894 0.503175 0.208426
ENSG00000105202 FBL UCS Amp 4.546785 1.021824 1.059339 0.625000
ENSG00000105202 FBL SARC Amp 1.161918 0.286679 0.728095 0.287938
ENSG00000105202 FBL PAAD Amp 5.062121 0.215184 0.590560 0.244565
ENSG00000105202 FBL BLCA Amp 3.030433 0.240203 0.558698 0.394608
ENSG00000105202 FBL BRCA Amp 1.323463 0.158167 0.567918 0.243519
ENSG00000105202 FBL UCEC Amp 6.471366 0.203157 0.890336 0.146568
ENSG00000105202 FBL OV Amp 22.386608 0.727586 1.128590 0.393782