Ensembl ID
ENSG00000104889
Gene ID
10535
Accession
18518
Gene Symbol
RNASEH2A
Alias
AGS4;JUNB;RNHL;RNHIA;THSD8;RNASEHI
Full Name
ribonuclease H2 subunit A
Position
19 : 12806584 - 12813640
Length
7057 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Canonical_RBPs
Summary
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
ENSG00000104889 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000104889
RNASEH2A
0.87
8.40e-29
KIRC
ENSG00000104889
RNASEH2A
1.26
4.74e-26
HNSC
ENSG00000104889
RNASEH2A
1.44
1.70e-16
BLCA
ENSG00000104889
RNASEH2A
1.79
8.30e-122
BRCA
ENSG00000104889
RNASEH2A
1.47
1.20e-33
COAD
ENSG00000104889
RNASEH2A
1.52
3.40e-11
READ
ENSG00000104889
RNASEH2A
2.25
3.32e-97
LUSC
ENSG00000104889
RNASEH2A
2.33
7.81e-13
GBM
ENSG00000104889
RNASEH2A
1.01
3.34e-18
KIRP
ENSG00000104889
RNASEH2A
1.87
7.62e-45
LIHC
ENSG00000104889
RNASEH2A
2.01
4.40e-46
UCEC
ENSG00000104889
RNASEH2A
1.69
2.15e-13
ESCA
ENSG00000104889
RNASEH2A
2.82
7.41e-11
CESC
ENSG00000104889
RNASEH2A
1.28
4.73e-29
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000104889
RNASEH2A
cancer
19139135
ENSG00000104889
RNASEH2A
tumour
19812674
ENSG00000104889
RNASEH2A
prostate cancer
25411967
ENSG00000104889
RNASEH2A
cancer
26603688
ENSG00000104889
RNASEH2A
colorectal tumor
27988520
ENSG00000104889
RNASEH2A
cancer
29642758
ENSG00000104889
RNASEH2A
colorectal cancer
29651323
ENSG00000104889
RNASEH2A
tumor
29843367
ENSG00000104889
RNASEH2A
tumours
29973717
ENSG00000104889
RNASEH2A
tumor
30273559
ENSG00000104889
RNASEH2A
cancer
30696738
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000104889
RNASEH2A
MESO
0.001
high
show
ENSG00000104889
RNASEH2A
SARC
0.0082
high
show
ENSG00000104889
RNASEH2A
STAD
0.0031
low
show
ENSG00000104889
RNASEH2A
PAAD
0.0032
high
show
ENSG00000104889
RNASEH2A
UCEC
0.027
low
show
ENSG00000104889
RNASEH2A
THCA
0.042
low
show
ENSG00000104889
RNASEH2A
LUSC
0.004
low
show
ENSG00000104889
RNASEH2A
HNSC
0.032
low
show
ENSG00000104889
RNASEH2A
READ
0.016
low
show
ENSG00000104889
RNASEH2A
LUAD
0.0033
high
show
ENSG00000104889
RNASEH2A
PCPG
0.00022
high
show
ENSG00000104889
RNASEH2A
THYM
0.0064
low
show
ENSG00000104889
RNASEH2A
BRCA
0.024
low
show
ENSG00000104889
RNASEH2A
COAD
0.0042
low
show
ENSG00000104889
RNASEH2A
OV
0.00015
low
show
ENSG00000104889
RNASEH2A
DLBC
0.029
low
show
ENSG00000104889
RNASEH2A
KIRC
0.00037
high
show
ENSG00000104889
RNASEH2A
TGCT
0.045
low
show
ENSG00000104889
RNASEH2A
LAML
0.00014
high
show
ENSG00000104889
RNASEH2A
GBM
0.033
low
show
ENSG00000104889
RNASEH2A
SKCM
0.0068
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000104889
RNASEH2A
LUAD
Del
0.964156
0.054972
0.341686
0.523256
ENSG00000104889
RNASEH2A
CESC
Amp
0.762300
0.130443
0.643982
0.138983
ENSG00000104889
RNASEH2A
LIHC
Del
2.310967
0.089831
0.440450
0.216216
ENSG00000104889
RNASEH2A
UCEC
Amp
7.689483
0.218731
0.798322
0.165121
ENSG00000104889
RNASEH2A
OV
Amp
18.622374
0.677194
0.947378
0.454231
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