Ensembl ID ENSG00000104824 Gene ID 3191 Accession 5045
Gene Symbol HNRNPL Alias HNRPL;hnRNP-L;P/OKcl.14 Full Name heterogeneous nuclear ribonucleoprotein L
Position 19 : 38836370 - 38852347 Length 15978 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000104824 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000104824 HNRNPL 0.49 2.22e-68 BRCA
ENSG00000104824 HNRNPL 0.67 1.34e-46 LUSC
ENSG00000104824 HNRNPL 0.37 1.50e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000104824 HNRNPL lung cancer 14696094
ENSG00000104824 HNRNPL tumors 19802719
ENSG00000104824 HNRNPL cancer 20237420
ENSG00000104824 HNRNPL lung cancer 20972334
ENSG00000104824 HNRNPL colorectal tumor 21194727
ENSG00000104824 HNRNPL tumor 24125732
ENSG00000104824 HNRNPL ovarian cancer 25667470
ENSG00000104824 HNRNPL tumor 26581192
ENSG00000104824 HNRNPL breast cancer 27666543
ENSG00000104824 HNRNPL pancreatic cancer 27689400
ENSG00000104824 HNRNPL tumor 27808105
ENSG00000104824 HNRNPL prostate cancer 28038443
ENSG00000104824 HNRNPL tumor 28088793
ENSG00000104824 HNRNPL tumor 28520992
ENSG00000104824 HNRNPL prostate cancer 28611215
ENSG00000104824 HNRNPL tumor 28622427
ENSG00000104824 HNRNPL cancers 28881634
ENSG00000104824 HNRNPL prostate cancer 29057311
ENSG00000104824 HNRNPL Cancer 29790588
ENSG00000104824 HNRNPL colorectal cancer 29869816
ENSG00000104824 HNRNPL tumor 29938870
ENSG00000104824 HNRNPL bladder cancer 30237493
ENSG00000104824 HNRNPL tumor 30430768
ENSG00000104824 HNRNPL prostate cancer 30939845
ENSG00000104824 HNRNPL tumors 31018621
ENSG00000104824 HNRNPL cancer 31138119
ENSG00000104824 HNRNPL tumors 31213844
ENSG00000104824 HNRNPL colorectal cancer 31320608
ENSG00000104824 HNRNPL colon cancer 31353791
ENSG00000104824 HNRNPL pancreatic cancer 31355266
ENSG00000104824 HNRNPL cancer 31492748
ENSG00000104824 HNRNPL cancer 31741723
ENSG00000104824 HNRNPL breast cancer 31828152
ENSG00000104824 HNRNPL tumor 31844595
ENSG00000104824 HNRNPL breast cancer 31856843
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000104824 HNRNPL SARC 0.0019 high
ENSG00000104824 HNRNPL STAD 0.027 low
ENSG00000104824 HNRNPL UVM 0.00017 high
ENSG00000104824 HNRNPL PAAD 0.0013 high
ENSG00000104824 HNRNPL UCEC 0.0088 high
ENSG00000104824 HNRNPL THCA 0.01 low
ENSG00000104824 HNRNPL LUSC 0.00092 low
ENSG00000104824 HNRNPL HNSC 0.0045 high
ENSG00000104824 HNRNPL READ 0.0012 low
ENSG00000104824 HNRNPL KIRP 0.00088 high
ENSG00000104824 HNRNPL KICH 0.0015 high
ENSG00000104824 HNRNPL LUAD 0.0011 high
ENSG00000104824 HNRNPL THYM 0.005 low
ENSG00000104824 HNRNPL BRCA 0.00053 low
ENSG00000104824 HNRNPL COAD 0.015 high
ENSG00000104824 HNRNPL PRAD 0.01 low
ENSG00000104824 HNRNPL TGCT 0.046 high
ENSG00000104824 HNRNPL BLCA 0.038 low
ENSG00000104824 HNRNPL GBM 0.0075 low
ENSG00000104824 HNRNPL SKCM 0.019 high
ENSG00000104824 HNRNPL CESC 0.05 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000104824 HNRNPL LUSC Amp 20.293072 0.549794 0.750309 0.459082
ENSG00000104824 HNRNPL LUAD Amp 5.057316 0.204386 0.527173 0.253876
ENSG00000104824 HNRNPL LGG Del 1.088027 0.043264 0.660544 0.430799
ENSG00000104824 HNRNPL CESC Amp 5.981615 0.285229 0.784393 0.315254
ENSG00000104824 HNRNPL UCS Amp 5.678060 1.140714 1.106118 0.642857
ENSG00000104824 HNRNPL SARC Amp 0.680851 0.257659 0.720727 0.280156
ENSG00000104824 HNRNPL PAAD Amp 5.218483 0.218740 0.573772 0.255435
ENSG00000104824 HNRNPL BLCA Amp 6.523641 0.322063 0.621821 0.406863
ENSG00000104824 HNRNPL UCEC Amp 5.097415 0.183871 0.834880 0.148423
ENSG00000104824 HNRNPL OV Amp 25.374914 0.765607 1.074216 0.433506