Ensembl ID ENSG00000104738 Gene ID 4173 Accession 6947
Gene Symbol MCM4 Alias NKCD;CDC21;CDC54;IMD54;NKGCD;hCdc21;P1-CDC21 Full Name minichromosome maintenance complex component 4
Position 8 : 47960185 - 47978160 Length 17976 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

ENSG00000104738 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000104738 MCM4 1.04 6.82e-24 HNSC
ENSG00000104738 MCM4 1.47 3.96e-15 BLCA
ENSG00000104738 MCM4 1.80 5.95e-86 BRCA
ENSG00000104738 MCM4 1.22 3.92e-32 COAD
ENSG00000104738 MCM4 2.98 1.73e-205 LUSC
ENSG00000104738 MCM4 1.60 1.22e-31 LIHC
ENSG00000104738 MCM4 1.38 3.05e-20 STAD
ENSG00000104738 MCM4 2.13 5.38e-51 UCEC
ENSG00000104738 MCM4 1.67 5.03e-12 ESCA
ENSG00000104738 MCM4 1.60 1.03e-11 CHOL
ENSG00000104738 MCM4 3.94 2.56e-44 CESC
ENSG00000104738 MCM4 2.20 8.21e-67 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000104738 MCM4 esophageal cancer 16133572
ENSG00000104738 MCM4 tumor 16595783
ENSG00000104738 MCM4 esophageal cancer 17222376
ENSG00000104738 MCM4 tumour 19453809
ENSG00000104738 MCM4 tumor 20398247
ENSG00000104738 MCM4 cancer 20884074
ENSG00000104738 MCM4 cancer 21619671
ENSG00000104738 MCM4 hepatic cancer 22505317
ENSG00000104738 MCM4 tumours 22668557
ENSG00000104738 MCM4 tumors 23133403
ENSG00000104738 MCM4 tumor 23463632
ENSG00000104738 MCM4 cervical cancer 23874974
ENSG00000104738 MCM4 tumours 24386425
ENSG00000104738 MCM4 cancer 24466173
ENSG00000104738 MCM4 colon cancer 25362258
ENSG00000104738 MCM4 breast cancer 25628920
ENSG00000104738 MCM4 skin cancer 25661590
ENSG00000104738 MCM4 breast cancer 25733866
ENSG00000104738 MCM4 gastric cancer 25916094
ENSG00000104738 MCM4 esophageal cancers 26156831
ENSG00000104738 MCM4 cervical cancer 26188903
ENSG00000104738 MCM4 breast cancer 26319982
ENSG00000104738 MCM4 cancer 26795696
ENSG00000104738 MCM4 ovarian cancer 27061550
ENSG00000104738 MCM4 lung cancer 27418131
ENSG00000104738 MCM4 cancer 27695057
ENSG00000104738 MCM4 cancer 27794528
ENSG00000104738 MCM4 ovarian cancer 28537669
ENSG00000104738 MCM4 cervical cancer 28670392
ENSG00000104738 MCM4 lung cancer 29084003
ENSG00000104738 MCM4 cancer 29135113
ENSG00000104738 MCM4 tumor 29180899
ENSG00000104738 MCM4 cancer 29642758
ENSG00000104738 MCM4 cervical cancer 29719595
ENSG00000104738 MCM4 tumors 29845895
ENSG00000104738 MCM4 tumor 30107825
ENSG00000104738 MCM4 cancer 30150654
ENSG00000104738 MCM4 tumor 30233242
ENSG00000104738 MCM4 cancer 30369561
ENSG00000104738 MCM4 AML 30480765
ENSG00000104738 MCM4 tumor 30846786
ENSG00000104738 MCM4 tumors 31044434
ENSG00000104738 MCM4 cancers 31323040
ENSG00000104738 MCM4 cancer 31379882
ENSG00000104738 MCM4 tumor 31387239
ENSG00000104738 MCM4 Cancers 31476594
ENSG00000104738 MCM4 endometrial cancer 31650984
ENSG00000104738 MCM4 cancer 31660150
ENSG00000104738 MCM4 tumor 31695969
ENSG00000104738 MCM4 breast cancer 31777591
ENSG00000104738 MCM4 Colorectal Cancer 31894983
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000104738 MCM4 SARC 0.00088 high
ENSG00000104738 MCM4 UVM 0.00014 high
ENSG00000104738 MCM4 THCA 0.021 low
ENSG00000104738 MCM4 LUSC 0.012 low
ENSG00000104738 MCM4 HNSC 0.016 low
ENSG00000104738 MCM4 READ 0.0023 low
ENSG00000104738 MCM4 LUAD 3e-04 high
ENSG00000104738 MCM4 PCPG 0.036 high
ENSG00000104738 MCM4 THYM 0.0045 low
ENSG00000104738 MCM4 COAD 0.0015 low
ENSG00000104738 MCM4 ESCA 0.0077 low
ENSG00000104738 MCM4 OV 0.045 low
ENSG00000104738 MCM4 DLBC 0.026 low
ENSG00000104738 MCM4 KIRC 0.00012 high
ENSG00000104738 MCM4 PRAD 0.035 low
ENSG00000104738 MCM4 LAML 0.0032 high
ENSG00000104738 MCM4 GBM 0.05 high
ENSG00000104738 MCM4 SKCM 0.022 high
ENSG00000104738 MCM4 CESC 0.0077 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000104738 MCM4 LUAD Amp 1.475358 0.137526 0.575912 0.449612
ENSG00000104738 MCM4 UCS Amp 3.256206 0.863558 1.193870 0.678571
ENSG00000104738 MCM4 HNSC Amp 2.765648 0.163246 0.587319 0.590038
ENSG00000104738 MCM4 BLCA Amp 0.771550 0.166522 0.593131 0.492647
ENSG00000104738 MCM4 BRCA Amp 3.932541 0.198087 0.872398 0.477778
ENSG00000104738 MCM4 UVM Amp 3.526633 0.325772 1.529711 0.587500