Ensembl ID ENSG00000104517 Gene ID 51366 Accession 16806
Gene Symbol UBR5 Alias DD5;EDD;HYD;EDD1 Full Name ubiquitin protein ligase E3 component n-recognin 5
Position 8 : 102252273 - 102412759 Length 160487 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

ENSG00000104517 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000104517 0.52 6.60e-12 LUSC
ENSG00000104517 0.63 2.16e-12 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000104517 cancers 10030672
ENSG00000104517 tumor 11309285
ENSG00000104517 cancers 12011095
ENSG00000104517 cancer 12902990
ENSG00000104517 tumor 14871824
ENSG00000104517 cancers 15282321
ENSG00000104517 tumor 1626955
ENSG00000104517 stomach cancer 16721783
ENSG00000104517 cancers 17074762
ENSG00000104517 cancer 17402705
ENSG00000104517 tumor 18047743
ENSG00000104517 cancer 18073532
ENSG00000104517 tumor 18076571
ENSG00000104517 epithelial ovarian cancer 18349819
ENSG00000104517 cancers 18425214
ENSG00000104517 tumor 20096703
ENSG00000104517 breast cancer 20544796
ENSG00000104517 cancer 21118991
ENSG00000104517 breast cancer 21383020
ENSG00000104517 tumor 21665252
ENSG00000104517 ovarian cancer 21924388
ENSG00000104517 cancers 21949371
ENSG00000104517 breast cancer 22242164
ENSG00000104517 breast cancer 22666407
ENSG00000104517 breast cancer 22695613
ENSG00000104517 cancers 23069210
ENSG00000104517 tumor 23499005
ENSG00000104517 cancer 23847653
ENSG00000104517 tumours 23878065
ENSG00000104517 breast cancer 24145130
ENSG00000104517 breast cancer 24189493
ENSG00000104517 epithelial ovarian cancer 24379240
ENSG00000104517 breast cancer 24441042
ENSG00000104517 cancer 24563673
ENSG00000104517 tumors 25886003
ENSG00000104517 tumour 26136413
ENSG00000104517 tumor 26234678
ENSG00000104517 Cancer 26464214
ENSG00000104517 HNSCC 26572163
ENSG00000104517 tumor 26968484
ENSG00000104517 gastric cancer 27124677
ENSG00000104517 cancer 27185398
ENSG00000104517 gastric cancer 27341561
ENSG00000104517 cervical cancer 27446260
ENSG00000104517 gastric cancer 27590582
ENSG00000104517 ovarian cancer 27721409
ENSG00000104517 tumors 28223694
ENSG00000104517 tumor 28330927
ENSG00000104517 ovarian cancer 28332316
ENSG00000104517 colorectal cancers 28689657
ENSG00000104517 Colorectal Cancer 28856538
ENSG00000104517 breast cancer 28977883
ENSG00000104517 cancer 29296225
ENSG00000104517 tumor 29344267
ENSG00000104517 cancer 29441057
ENSG00000104517 colon cancer 29441938
ENSG00000104517 ovarian cancer 29607295
ENSG00000104517 cancer 29742019
ENSG00000104517 tumor 29944885
ENSG00000104517 Cancer 30172261
ENSG00000104517 cancer 30416686
ENSG00000104517 cancer 30598114
ENSG00000104517 tumor 30775814
ENSG00000104517 tumor 30804124
ENSG00000104517 cancer 30894683
ENSG00000104517 breast cancer 31392083
ENSG00000104517 prostate cancer 31472148
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000104517 esophageal adenocarcinoma sequence_alteration 9.132% (40/438) 1 entry
ENSG00000104517 esophageal adenocarcinoma frameshift_variant 9.132% (40/438) 1 entry
ENSG00000104517 Mantle cell lymphoma stop_gained 12.95% (25/193) 2 entries
ENSG00000104517 colorectal adenocarcinoma sequence_alteration 10.11% (126/1246) 2 entries
ENSG00000104517 esophageal adenocarcinoma missense_variant 9.132% (40/438) 1 entry
ENSG00000104517 breast ductal adenocarcinoma sequence_alteration 13.97% (102/730) 1 entry
ENSG00000104517 melanoma missense_variant 13.86% (14/101) 2 entries
ENSG00000104517 Mantle cell lymphoma frameshift_variant 12.95% (25/193) 2 entries
ENSG00000104517 colorectal adenocarcinoma stop_gained 10.11% (126/1246) 2 entries
ENSG00000104517 colorectal adenocarcinoma missense_variant 10.11% (126/1246) 6 entries
ENSG00000104517 HER2 Positive Breast Carcinoma missense_variant 12.58% (20/159) 2 entries
ENSG00000104517 colorectal adenocarcinoma frameshift_variant 10.11% (126/1246) 3 entries
ENSG00000104517 Mantle cell lymphoma missense_variant 12.95% (25/193) 3 entries
ENSG00000104517 melanoma frameshift_variant 13.86% (14/101) 1 entry
ENSG00000104517 Mantle cell lymphoma sequence_alteration 12.95% (25/193) 2 entries
ENSG00000104517 breast ductal adenocarcinoma missense_variant 13.97% (102/730) 1 entry
ENSG00000104517 prostate adenocarcinoma missense_variant 4.883% (71/1454) 1 entry
ENSG00000104517 head and neck squamous cell carcinoma sequence_alteration 2.011% (15/746) 1 entry
ENSG00000104517 cecum adenocarcinoma stop_gained 11.36% (15/132) 1 entry
ENSG00000104517 gastric adenocarcinoma frameshift_variant 4.15% (32/771) 2 entries
ENSG00000104517 head and neck squamous cell carcinoma missense_variant 2.011% (15/746) 2 entries
ENSG00000104517 Dysplasia in Ulcerative Colitis missense_variant 25.0% (2/8) 1 entry
ENSG00000104517 prostate carcinoma missense_variant 3.099% (15/484) 1 entry
ENSG00000104517 prostate adenocarcinoma stop_gained 4.883% (71/1454) 1 entry
ENSG00000104517 female breast carcinoma missense_variant 3.069% (12/391) 3 entries
ENSG00000104517 pancreatic ductal adenocarcinoma missense_variant 5.163% (65/1259) 2 entries
ENSG00000104517 Merkel cell skin cancer missense_variant 10.0% (3/30) 1 entry
ENSG00000104517 ovarian serous adenocarcinoma missense_variant 1.189% (8/673) 1 entry
ENSG00000104517 Cervical Small Cell Carcinoma missense_variant 50.0% (3/6) 1 entry
ENSG00000104517 bladder transitional cell carcinoma missense_variant 2.92% (4/137) 2 entries
ENSG00000104517 non-small cell lung carcinoma missense_variant 8.257% (9/109) 3 entries
ENSG00000104517 bile duct adenocarcinoma missense_variant 1.058% (2/189) 1 entry
ENSG00000104517 esophageal squamous cell carcinoma frameshift_variant 3.259% (22/675) 2 entries
ENSG00000104517 gastric adenocarcinoma sequence_alteration 4.15% (32/771) 1 entry
ENSG00000104517 ovarian serous adenocarcinoma sequence_alteration 1.189% (8/673) 2 entries
ENSG00000104517 esophageal squamous cell carcinoma stop_gained 3.259% (22/675) 3 entries
ENSG00000104517 hepatocellular carcinoma missense_variant 2.323% (22/947) 2 entries
ENSG00000104517 nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000104517 lung adenocarcinoma stop_gained 3.273% (40/1222) 2 entries
ENSG00000104517 clear cell renal carcinoma missense_variant 1.379% (19/1378) 2 entries
ENSG00000104517 basal cell carcinoma missense_variant 10.34% (6/58) 1 entry
ENSG00000104517 colon adenocarcinoma sequence_alteration 5.867% (45/767) 3 entries
ENSG00000104517 large cell lung carcinoma missense_variant 11.11% (2/18) 1 entry
ENSG00000104517 alveolar rhabdomyosarcoma missense_variant 3.39% (2/59) 2 entries
ENSG00000104517 basal cell carcinoma sequence_alteration 10.34% (6/58) 1 entry
ENSG00000104517 colon adenocarcinoma stop_gained 5.867% (45/767) 4 entries
ENSG00000104517 brain glioblastoma missense_variant 0.324% (3/926) 1 entry
ENSG00000104517 clear cell renal carcinoma sequence_alteration 1.379% (19/1378) 1 entry
ENSG00000104517 skin melanoma missense_variant 4.033% (39/967) 6 entries
ENSG00000104517 metaplastic breast carcinoma missense_variant 7.843% (4/51) 1 entry
ENSG00000104517 chronic lymphocytic leukemia missense_variant 1.014% (9/888) 2 entries
ENSG00000104517 skin melanoma sequence_alteration 4.033% (39/967) 2 entries
ENSG00000104517 prostate carcinoma sequence_alteration 3.099% (15/484) 1 entry
ENSG00000104517 adenosquamous lung carcinoma missense_variant 27.27% (3/11) 1 entry
ENSG00000104517 gastric adenocarcinoma missense_variant 4.15% (32/771) 4 entries
ENSG00000104517 colon adenocarcinoma frameshift_variant 5.867% (45/767) 3 entries
ENSG00000104517 colon adenocarcinoma missense_variant 5.867% (45/767) 5 entries
ENSG00000104517 breast carcinoma missense_variant 1.843% (26/1411) 2 entries
ENSG00000104517 cecum adenocarcinoma missense_variant 11.36% (15/132) 1 entry
ENSG00000104517 esophageal squamous cell carcinoma missense_variant 3.259% (22/675) 5 entries
ENSG00000104517 cecum adenocarcinoma frameshift_variant 11.36% (15/132) 2 entries
ENSG00000104517 papillary renal cell carcinoma missense_variant 0.597% (2/335) 1 entry
ENSG00000104517 gastric intestinal type adenocarcinoma frameshift_variant 11.76% (10/85) 2 entries
ENSG00000104517 small cell lung carcinoma missense_variant 1.548% (5/323) 3 entries
ENSG00000104517 bladder carcinoma missense_variant 6.306% (35/555) 1 entry
ENSG00000104517 prostate adenocarcinoma sequence_alteration 4.883% (71/1454) 2 entries
ENSG00000104517 oral squamous cell carcinoma missense_variant 2.927% (6/205) 4 entries
ENSG00000104517 gastric intestinal type adenocarcinoma missense_variant 11.76% (10/85) 2 entries
ENSG00000104517 ovarian carcinoma missense_variant 40.0% (4/10) 1 entry
ENSG00000104517 Ampulla of Vater Carcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000104517 clear cell renal carcinoma frameshift_variant 1.379% (19/1378) 1 entry
ENSG00000104517 lung adenocarcinoma missense_variant 3.273% (40/1222) 8 entries
ENSG00000104517 squamous cell lung carcinoma missense_variant 2.4% (21/875) 4 entries
ENSG00000104517 rectal adenocarcinoma missense_variant 1.762% (4/227) 2 entries
ENSG00000104517 ulcerative colitis missense_variant 11.11% (1/9) 1 entry
ENSG00000104517 osteosarcoma frameshift_variant 1.724% (2/116) 1 entry
ENSG00000104517 oral squamous cell carcinoma frameshift_variant 2.927% (6/205) 1 entry
ENSG00000104517 skin carcinoma missense_variant 4.808% (5/104) 1 entry
ENSG00000104517 female breast carcinoma stop_gained 3.069% (12/391) 1 entry
ENSG00000104517 diffuse gastric adenocarcinoma missense_variant 1.266% (1/79) 1 entry
ENSG00000104517 Pancreatic Acinar Cell Carcinoma sequence_alteration 15.0% (3/20) 1 entry
ENSG00000104517 endometrial stromal sarcoma missense_variant 8.333% (1/12) 1 entry
ENSG00000104517 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma sequence_alteration 16.67% (1/6) 1 entry
ENSG00000104517 bladder transitional cell carcinoma sequence_alteration 2.92% (4/137) 1 entry
ENSG00000104517 skin melanoma frameshift_variant 4.033% (39/967) 1 entry
ENSG00000104517 gastric intestinal type adenocarcinoma sequence_alteration 11.76% (10/85) 1 entry
ENSG00000104517 Ocular Sebaceous Carcinoma stop_gained 4.348% (1/23) 1 entry
ENSG00000104517 Brain Stem Glioblastoma frameshift_variant 3.571% (2/56) 1 entry
ENSG00000104517 bronchoalveolar adenocarcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000104517 endometrial carcinoma stop_gained 4.348% (1/23) 1 entry
ENSG00000104517 Pancreatic Acinar Cell Carcinoma frameshift_variant 15.0% (3/20) 1 entry
ENSG00000104517 basal cell carcinoma stop_gained 10.34% (6/58) 1 entry
ENSG00000104517 neoplasm missense_variant 7.143% (2/28) 1 entry
ENSG00000104517 ovarian mucinous adenocarcinoma missense_variant 7.692% (1/13) 1 entry
ENSG00000104517 endometrial carcinoma missense_variant 4.348% (1/23) 1 entry
ENSG00000104517 adenosquamous lung carcinoma sequence_alteration 27.27% (3/11) 1 entry
ENSG00000104517 medullary thyroid gland carcinoma sequence_alteration 5.263% (1/19) 1 entry
ENSG00000104517 small cell lung carcinoma stop_gained 1.548% (5/323) 1 entry
ENSG00000104517 female breast carcinoma frameshift_variant 3.069% (12/391) 1 entry
ENSG00000104517 Merkel cell skin cancer sequence_alteration 10.0% (3/30) 1 entry
ENSG00000104517 large cell lung carcinoma stop_gained 11.11% (2/18) 1 entry
ENSG00000104517 lung adenocarcinoma sequence_alteration 3.273% (40/1222) 1 entry
ENSG00000104517 lung adenocarcinoma conservative_inframe_deletion 3.273% (40/1222) 1 entry
ENSG00000104517 Testicular Non-Seminomatous Germ Cell Tumor missense_variant 33.33% (1/3) 1 entry
ENSG00000104517 acute lymphoblastic leukemia missense_variant 0.3115% (1/321) 1 entry
ENSG00000104517 head and neck squamous cell carcinoma frameshift_variant 2.011% (15/746) 1 entry
ENSG00000104517 osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000104517 nodular melanoma missense_variant 50.0% (1/2) 1 entry
ENSG00000104517 ovarian neoplasm sequence_alteration 1.724% (1/58) 1 entry
ENSG00000104517 Endometrial Clear Cell Adenocarcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000104517 rectal adenocarcinoma frameshift_variant 1.762% (4/227) 1 entry
ENSG00000104517 gastric intestinal type adenocarcinoma stop_gained 11.76% (10/85) 1 entry
ENSG00000104517 embryonal rhabdomyosarcoma missense_variant 1.316% (1/76) 1 entry
ENSG00000104517 non-small cell lung carcinoma stop_gained 8.257% (9/109) 1 entry
ENSG00000104517 ependymoma sequence_alteration 2.174% (1/46) 1 entry
ENSG00000104517 Brain Stem Glioblastoma sequence_alteration 3.571% (2/56) 1 entry
ENSG00000104517 Pancreatic Acinar Cell Carcinoma missense_variant 15.0% (3/20) 1 entry
ENSG00000104517 squamous cell lung carcinoma stop_gained 2.4% (21/875) 1 entry
ENSG00000104517 squamous cell lung carcinoma sequence_alteration 2.4% (21/875) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000104517 SARC 0.0059 high
ENSG00000104517 CHOL 0.016 low
ENSG00000104517 PAAD 0.0069 high
ENSG00000104517 UCEC 0.015 high
ENSG00000104517 THCA 0.018 high
ENSG00000104517 ACC 0.0073 high
ENSG00000104517 READ 0.02 low
ENSG00000104517 KIRP 0.0018 high
ENSG00000104517 BRCA 0.0025 high
ENSG00000104517 OV 0.0013 high
ENSG00000104517 KIRC 0.0032 low
ENSG00000104517 PRAD 0.016 high
ENSG00000104517 LAML 0.0023 low
ENSG00000104517 GBM 0.0094 low
ENSG00000104517 CESC 0.0053 high
ENSG00000104517 LIHC 0.00011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000104517 LUSC Amp 1.606156 0.223943 0.534604 0.614770
ENSG00000104517 LUAD Amp 6.368217 0.224836 0.619110 0.571705
ENSG00000104517 LGG Amp 8.825532 0.139870 0.685714 0.173489
ENSG00000104517 CESC Amp 1.178795 0.147852 0.627227 0.376271
ENSG00000104517 READ Amp 2.676555 0.218858 0.803269 0.630303
ENSG00000104517 COAD Amp 4.353856 0.130649 0.781568 0.560976
ENSG00000104517 UCS Amp 0.751957 0.502100 1.129011 0.696429
ENSG00000104517 ESCA Amp 2.858331 0.380982 0.655419 0.684783
ENSG00000104517 SKCM Amp 1.047724 0.131787 0.764406 0.490463
ENSG00000104517 HNSC Amp 3.037288 0.168374 0.576802 0.695402
ENSG00000104517 LIHC Amp 13.983360 0.343606 1.165976 0.616216
ENSG00000104517 BLCA Amp 31.204196 0.715251 0.917981 0.629902
ENSG00000104517 BRCA Amp 42.322786 0.501759 1.058646 0.612963
ENSG00000104517 STAD Amp 4.974511 0.236988 0.623989 0.637188
ENSG00000104517 PRAD Amp 3.850748 0.089033 0.711970 0.321138
ENSG00000104517 UCEC Amp 0.727589 0.103400 0.758952 0.339518
ENSG00000104517 UVM Amp 9.477347 0.581109 1.507945 0.750000
ENSG00000104517 KICH Amp 0.662421 0.210601 0.966492 0.287879
ENSG00000104517 OV Amp 20.756845 0.705948 0.973693 0.625216