Ensembl ID ENSG00000104408 Gene ID 3646 Accession 3277
Gene Symbol EIF3E Alias INT6;EIF3S6;EIF3-P48;eIF3-p46 Full Name eukaryotic translation initiation factor 3 subunit E
Position 8 : 108162787 - 108443496 Length 280710 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000104408 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000104408 EIF3E 0.50 4.97e-16 KIRC
ENSG00000104408 EIF3E 0.81 1.19e-13 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000104408 EIF3E tumors 11115556
ENSG00000104408 EIF3E breast cancer 11121040
ENSG00000104408 EIF3E tumor 11134033
ENSG00000104408 EIF3E tumor 11457827
ENSG00000104408 EIF3E tumors 11536042
ENSG00000104408 EIF3E tumor 11904180
ENSG00000104408 EIF3E tumours 15030549
ENSG00000104408 EIF3E colorectal cancers 15750208
ENSG00000104408 EIF3E tumor 17310990
ENSG00000104408 EIF3E tumor 17324924
ENSG00000104408 EIF3E tumor 17385060
ENSG00000104408 EIF3E tumor 17698014
ENSG00000104408 EIF3E cancer 17895999
ENSG00000104408 EIF3E tumors 18709449
ENSG00000104408 EIF3E tumor 19329653
ENSG00000104408 EIF3E breast cancer 20453879
ENSG00000104408 EIF3E tumor 20890303
ENSG00000104408 EIF3E bladder cancer 21672358
ENSG00000104408 EIF3E tumor 21737453
ENSG00000104408 EIF3E breast cancers 22508697
ENSG00000104408 EIF3E tumor 22734884
ENSG00000104408 EIF3E breast cancers 22907435
ENSG00000104408 EIF3E tumor 22960363
ENSG00000104408 EIF3E tumor 23478175
ENSG00000104408 EIF3E tumor 24481065
ENSG00000104408 EIF3E lung cancers 24847761
ENSG00000104408 EIF3E tumour 25123227
ENSG00000104408 EIF3E colon cancer 25400724
ENSG00000104408 EIF3E colorectal cancer 25531322
ENSG00000104408 EIF3E breast cancer 25774287
ENSG00000104408 EIF3E lung cancer 26056130
ENSG00000104408 EIF3E tumor 26779407
ENSG00000104408 EIF3E bladder cancer 27451077
ENSG00000104408 EIF3E cancer 27477275
ENSG00000104408 EIF3E breast cancer 27550454
ENSG00000104408 EIF3E tumor 27814599
ENSG00000104408 EIF3E cancers 28083147
ENSG00000104408 EIF3E tumor 28505193
ENSG00000104408 EIF3E tumor 28622887
ENSG00000104408 EIF3E colon cancer 28695896
ENSG00000104408 EIF3E cancer 28981723
ENSG00000104408 EIF3E colon cancer 29181107
ENSG00000104408 EIF3E tumor 29568350
ENSG00000104408 EIF3E tumor 29675094
ENSG00000104408 EIF3E tumors 30087825
ENSG00000104408 EIF3E tumour 30243646
ENSG00000104408 EIF3E colorectal cancer 30916365
ENSG00000104408 EIF3E tumor 9260927
ENSG00000104408 EIF3E tumor 9295280
ENSG00000104408 EIF3E tumor 9403073
ENSG00000104408 EIF3E tumours 9513725
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000104408 EIF3E colon adenocarcinoma sequence_alteration 9.343% (74/792) 2 entries
ENSG00000104408 EIF3E esophageal adenocarcinoma missense_variant 7.078% (31/438) 1 entry
ENSG00000104408 EIF3E colon adenocarcinoma missense_variant 9.343% (74/792) 2 entries
ENSG00000104408 EIF3E colon adenocarcinoma gene_fusion 9.343% (74/792) 1 entry
ENSG00000104408 EIF3E breast ductal adenocarcinoma sequence_alteration 6.678% (39/584) 2 entries
ENSG00000104408 EIF3E Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000104408 EIF3E colorectal adenocarcinoma sequence_alteration 2.285% (26/1138) 3 entries
ENSG00000104408 EIF3E squamous cell lung carcinoma sequence_alteration 1.05% (8/762) 1 entry
ENSG00000104408 EIF3E central nervous system primitive neuroectodermal neoplasm sequence_alteration 0.6757% (3/444) 1 entry
ENSG00000104408 EIF3E central nervous system primitive neuroectodermal neoplasm missense_variant 0.6757% (3/444) 1 entry
ENSG00000104408 EIF3E cecum adenocarcinoma stop_gained 3.2% (4/125) 1 entry
ENSG00000104408 EIF3E prostate carcinoma missense_variant 1.408% (6/426) 2 entries
ENSG00000104408 EIF3E metaplastic breast carcinoma missense_variant 3.922% (2/51) 2 entries
ENSG00000104408 EIF3E melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000104408 EIF3E squamous cell lung carcinoma missense_variant 1.05% (8/762) 1 entry
ENSG00000104408 EIF3E head and neck squamous cell carcinoma sequence_alteration 3.514% (22/626) 1 entry
ENSG00000104408 EIF3E small cell lung carcinoma missense_variant 0.6309% (2/317) 2 entries
ENSG00000104408 EIF3E clear cell renal carcinoma sequence_alteration 0.2177% (3/1378) 2 entries
ENSG00000104408 EIF3E ovarian serous adenocarcinoma missense_variant 0.5944% (4/673) 1 entry
ENSG00000104408 EIF3E Merkel cell skin cancer sequence_alteration 6.667% (2/30) 1 entry
ENSG00000104408 EIF3E skin melanoma missense_variant 0.6205% (6/967) 1 entry
ENSG00000104408 EIF3E prostate carcinoma sequence_alteration 1.408% (6/426) 1 entry
ENSG00000104408 EIF3E colorectal adenocarcinoma missense_variant 2.285% (26/1138) 2 entries
ENSG00000104408 EIF3E lung adenocarcinoma missense_variant 0.6879% (8/1163) 3 entries
ENSG00000104408 EIF3E bladder transitional cell carcinoma missense_variant 1.46% (2/137) 1 entry
ENSG00000104408 EIF3E clear cell renal carcinoma missense_variant 0.2177% (3/1378) 1 entry
ENSG00000104408 EIF3E lung adenocarcinoma sequence_alteration 0.6879% (8/1163) 1 entry
ENSG00000104408 EIF3E Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000104408 EIF3E ovarian serous adenocarcinoma frameshift_variant 0.5944% (4/673) 1 entry
ENSG00000104408 EIF3E bronchoalveolar adenocarcinoma sequence_alteration 4.545% (1/22) 1 entry
ENSG00000104408 EIF3E laryngeal squamous cell carcinoma missense_variant 3.846% (1/26) 1 entry
ENSG00000104408 EIF3E Mantle cell lymphoma sequence_alteration 2.439% (1/41) 1 entry
ENSG00000104408 EIF3E osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000104408 EIF3E rectal adenocarcinoma missense_variant 0.4525% (1/221) 1 entry
ENSG00000104408 EIF3E bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
ENSG00000104408 EIF3E head and neck squamous cell carcinoma missense_variant 3.514% (22/626) 1 entry
ENSG00000104408 EIF3E rectal adenocarcinoma sequence_alteration 0.4525% (1/221) 1 entry
ENSG00000104408 EIF3E colorectal adenocarcinoma stop_gained 2.285% (26/1138) 1 entry
ENSG00000104408 EIF3E bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000104408 EIF3E hepatocellular carcinoma frameshift_variant 0.9978% (9/902) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000104408 EIF3E MESO 0.01 low
ENSG00000104408 EIF3E SARC 0.0063 high
ENSG00000104408 EIF3E UVM 0.0063 high
ENSG00000104408 EIF3E THCA 0.047 high
ENSG00000104408 EIF3E ACC 0.026 high
ENSG00000104408 EIF3E HNSC 0.0081 high
ENSG00000104408 EIF3E KICH 0.0024 high
ENSG00000104408 EIF3E LUAD 0.013 high
ENSG00000104408 EIF3E THYM 0.046 low
ENSG00000104408 EIF3E BRCA 0.028 high
ENSG00000104408 EIF3E ESCA 0.033 high
ENSG00000104408 EIF3E PRAD 0.041 low
ENSG00000104408 EIF3E LAML 0.00035 low
ENSG00000104408 EIF3E GBM 0.0078 low
ENSG00000104408 EIF3E CESC 0.026 high
ENSG00000104408 EIF3E LIHC 0.021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000104408 EIF3E LUSC Amp 4.595572 0.297818 0.562071 0.634731
ENSG00000104408 EIF3E LUAD Amp 3.274424 0.174301 0.583086 0.565891
ENSG00000104408 EIF3E LGG Amp 11.323237 0.163353 0.720696 0.181287
ENSG00000104408 EIF3E CESC Amp 1.099675 0.144377 0.615602 0.379661
ENSG00000104408 EIF3E READ Amp 1.924165 0.185605 0.781546 0.636364
ENSG00000104408 EIF3E COAD Amp 6.270814 0.160177 0.797098 0.565410
ENSG00000104408 EIF3E ESCA Amp 2.123841 0.343907 0.645911 0.690217
ENSG00000104408 EIF3E SKCM Amp 1.612329 0.150049 0.761958 0.501362
ENSG00000104408 EIF3E HNSC Amp 3.467487 0.176949 0.578407 0.703065
ENSG00000104408 EIF3E LIHC Amp 16.244711 0.373293 1.185594 0.610811
ENSG00000104408 EIF3E BLCA Amp 4.921797 0.287507 0.650288 0.610294
ENSG00000104408 EIF3E BRCA Amp 38.100666 0.474880 1.033314 0.612963
ENSG00000104408 EIF3E STAD Amp 3.674244 0.209481 0.606344 0.637188
ENSG00000104408 EIF3E PRAD Amp 3.751512 0.087750 0.713293 0.315041
ENSG00000104408 EIF3E UCEC Amp 2.757026 0.146840 0.808456 0.346939
ENSG00000104408 EIF3E UVM Amp 9.621464 0.588242 1.506450 0.750000
ENSG00000104408 EIF3E OV Amp 38.326026 0.915702 1.044071 0.664940