Ensembl ID ENSG00000104067 Gene ID 7082 Accession 11827
Gene Symbol TJP1 Alias ZO-1 Full Name tight junction protein 1
Position 15 : 29699367 - 29968915 Length 269549 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

ENSG00000104067 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000104067 -0.4 1.52e-14 KIRC
ENSG00000104067 -0.9 2.91e-17 HNSC
ENSG00000104067 -0.6 3.38e-27 BRCA
ENSG00000104067 -1.2 4.13e-47 LUSC
ENSG00000104067 -0.9 5.65e-22 UCEC
ENSG00000104067 -0.9 6.23e-30 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000104067 tumor 10526152
ENSG00000104067 pancreatic cancer 11590321
ENSG00000104067 tumor 11792963
ENSG00000104067 tumour 11802782
ENSG00000104067 tumor 15518882
ENSG00000104067 tumor 16452224
ENSG00000104067 tumour 19126183
ENSG00000104067 tumors 19841737
ENSG00000104067 tumor 22241858
ENSG00000104067 tumours 23300147
ENSG00000104067 breast cancer 24735924
ENSG00000104067 cancer 24910533
ENSG00000104067 lung cancer 25027596
ENSG00000104067 breast cancer 25089631
ENSG00000104067 cancer 25609232
ENSG00000104067 tumor 25755686
ENSG00000104067 breast tumors 26293574
ENSG00000104067 breast cancer 26462028
ENSG00000104067 tumor 26543233
ENSG00000104067 tumor 26778715
ENSG00000104067 tumour 26840831
ENSG00000104067 prostate cancer 26934365
ENSG00000104067 Cancer 27165736
ENSG00000104067 tumor 27602775
ENSG00000104067 cancer 28231804
ENSG00000104067 lung cancer 28436951
ENSG00000104067 breast cancer 28761621
ENSG00000104067 tumor 28966941
ENSG00000104067 breast cancer 29881285
ENSG00000104067 Bladder Cancer 30061227
ENSG00000104067 ovarian cancer 30214617
ENSG00000104067 cancer 30872568
ENSG00000104067 tumor 31114375
ENSG00000104067 tumor 31358901
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000104067 MESO 0.039 high
ENSG00000104067 STAD 0.0031 high
ENSG00000104067 CHOL 0.019 low
ENSG00000104067 PAAD 0.0029 high
ENSG00000104067 UCEC 0.014 low
ENSG00000104067 ACC 0.00073 high
ENSG00000104067 LUSC 0.0045 high
ENSG00000104067 LUAD 0.021 high
ENSG00000104067 THYM 0.012 high
ENSG00000104067 BRCA 0.00026 high
ENSG00000104067 BLCA 0.012 high
ENSG00000104067 LAML 0.00068 low
ENSG00000104067 GBM 0.049 low
ENSG00000104067 SKCM 0.0011 low
ENSG00000104067 LIHC 0.024 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000104067 LUSC Del 3.813579 0.102214 0.337090 0.349301
ENSG00000104067 LUAD Del 9.240824 0.121693 0.330305 0.523256
ENSG00000104067 READ Del 0.629941 0.068240 0.466728 0.460606
ENSG00000104067 COAD Del 4.787700 0.078978 0.466845 0.388027
ENSG00000104067 UCS Del 6.157638 0.523925 0.579206 0.732143
ENSG00000104067 GBM Del 5.189208 0.094005 0.489661 0.214905
ENSG00000104067 PAAD Del 0.760000 0.046483 0.313765 0.190217
ENSG00000104067 ESCA Del 0.643259 0.094732 0.331098 0.326087
ENSG00000104067 SKCM Del 6.368945 0.136880 0.484098 0.198910
ENSG00000104067 BLCA Del 3.458583 0.117022 0.355272 0.389706
ENSG00000104067 BRCA Del 16.043520 0.136133 0.411699 0.345370
ENSG00000104067 STAD Del 2.623079 0.085925 0.336759 0.269841
ENSG00000104067 UCEC Del 3.779975 0.079140 0.511693 0.235622
ENSG00000104067 MESO Del 4.345304 0.248885 0.535559 0.275862
ENSG00000104067 OV Del 14.501639 0.339754 0.599689 0.564767