Ensembl ID ENSG00000103356 Gene ID 124454 Accession 29419
Gene Symbol EARS2 Alias MSE1;gluRS;COXPD12;mtGlnRS Full Name glutamyl-tRNA synthetase 2, mitochondrial
Position 16 : 23520754 - 23557731 Length 36978 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

ENSG00000103356 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000103356 EARS2 0.72 2.58e-38 BRCA
ENSG00000103356 EARS2 0.65 9.71e-24 COAD
ENSG00000103356 EARS2 1.30 4.11e-39 KICH
ENSG00000103356 EARS2 0.67 4.94e-20 LUSC
ENSG00000103356 EARS2 0.75 1.11e-27 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000103356 EARS2 tumor 2002062
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000103356 EARS2 SARC 0.01 high
ENSG00000103356 EARS2 PAAD 0.0011 high
ENSG00000103356 EARS2 ACC 0.015 low
ENSG00000103356 EARS2 LGG 0.023 low
ENSG00000103356 EARS2 HNSC 0.038 high
ENSG00000103356 EARS2 PCPG 0.041 low
ENSG00000103356 EARS2 THYM 0.019 high
ENSG00000103356 EARS2 BRCA 0.024 high
ENSG00000103356 EARS2 OV 0.035 low
ENSG00000103356 EARS2 KIRC 0.00012 low
ENSG00000103356 EARS2 BLCA 0.035 high
ENSG00000103356 EARS2 SKCM 0.00074 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000103356 EARS2 GBM Del 1.483583 0.061732 0.410304 0.159445