Ensembl ID ENSG00000102144 Gene ID 5230 Accession 8896
Gene Symbol PGK1 Alias PGKA;MIG10;HEL-S-68p Full Name phosphoglycerate kinase 1
Position X : 77910739 - 78129295 Length 218557 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

ENSG00000102144 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000102144 PGK1 0.88 8.01e-28 KIRC
ENSG00000102144 PGK1 0.82 5.49e-32 BRCA
ENSG00000102144 PGK1 0.70 1.32e-12 COAD
ENSG00000102144 PGK1 1.28 5.62e-31 LUSC
ENSG00000102144 PGK1 1.10 6.33e-15 UCEC
ENSG00000102144 PGK1 0.76 1.56e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000102144 PGK1 bone tumors 1429207
ENSG00000102144 PGK1 lung tumors 14573703
ENSG00000102144 PGK1 tumor 1535155
ENSG00000102144 PGK1 tumor 15355913
ENSG00000102144 PGK1 breast tumors 16048908
ENSG00000102144 PGK1 primary cancer 16313824
ENSG00000102144 PGK1 tumour 16319328
ENSG00000102144 PGK1 tumors 16493704
ENSG00000102144 PGK1 tumor 17210694
ENSG00000102144 PGK1 tumors 18401453
ENSG00000102144 PGK1 gastric cancer 18453750
ENSG00000102144 PGK1 cancer 18569371
ENSG00000102144 PGK1 tumor 18814280
ENSG00000102144 PGK1 tumour 19200351
ENSG00000102144 PGK1 cancer 19221597
ENSG00000102144 PGK1 ovarian cancers 19333399
ENSG00000102144 PGK1 breast tumors 19544972
ENSG00000102144 PGK1 pancreatic cancer 19582723
ENSG00000102144 PGK1 gastric cancer 19688824
ENSG00000102144 PGK1 cancer 19689405
ENSG00000102144 PGK1 prostate cancer 19825988
ENSG00000102144 PGK1 prostate cancer 19893039
ENSG00000102144 PGK1 tumor 20068185
ENSG00000102144 PGK1 tumor 20731664
ENSG00000102144 PGK1 gastric cancer 20798498
ENSG00000102144 PGK1 prostate cancer 20868494
ENSG00000102144 PGK1 tumors 20961996
ENSG00000102144 PGK1 cancer 21045262
ENSG00000102144 PGK1 tumors 21058741
ENSG00000102144 PGK1 prostate cancer 21780947
ENSG00000102144 PGK1 lung cancer 22229091
ENSG00000102144 PGK1 tumor 22614725
ENSG00000102144 PGK1 tumor 22706893
ENSG00000102144 PGK1 tumors 22742733
ENSG00000102144 PGK1 prostate tumors 22926970
ENSG00000102144 PGK1 ovarian cancer 23060548
ENSG00000102144 PGK1 breast cancer 23130662
ENSG00000102144 PGK1 cancer 23216862
ENSG00000102144 PGK1 tumour 23301832
ENSG00000102144 PGK1 gastric cancer 23412594
ENSG00000102144 PGK1 tumor 23543897
ENSG00000102144 PGK1 cancer 23684136
ENSG00000102144 PGK1 colon cancer 23727790
ENSG00000102144 PGK1 cancer 24346158
ENSG00000102144 PGK1 tumor 24376734
ENSG00000102144 PGK1 lung cancer 24450150
ENSG00000102144 PGK1 breast cancer 24564733
ENSG00000102144 PGK1 cancer 24721582
ENSG00000102144 PGK1 ovarian cancer 25096996
ENSG00000102144 PGK1 tumor 25175369
ENSG00000102144 PGK1 lung cancer 25573171
ENSG00000102144 PGK1 prostate cancer 25647662
ENSG00000102144 PGK1 tumor 25734817
ENSG00000102144 PGK1 tumour 25867275
ENSG00000102144 PGK1 breast cancers 25986046
ENSG00000102144 PGK1 tumor 26131450
ENSG00000102144 PGK1 oral cancer 26171676
ENSG00000102144 PGK1 tumor 26298000
ENSG00000102144 PGK1 tumour 26510737
ENSG00000102144 PGK1 tumor 26634812
ENSG00000102144 PGK1 tumor 26656369
ENSG00000102144 PGK1 cancer 26840568
ENSG00000102144 PGK1 cancer 26942675
ENSG00000102144 PGK1 prostate cancer 26955882
ENSG00000102144 PGK1 cancer 26962435
ENSG00000102144 PGK1 tumor 27109021
ENSG00000102144 PGK1 laryngeal cancer 27446427
ENSG00000102144 PGK1 GBM 27536856
ENSG00000102144 PGK1 tumors 27741516
ENSG00000102144 PGK1 liver cancer 27774669
ENSG00000102144 PGK1 oral cancer 28243334
ENSG00000102144 PGK1 prostate cancer 28391351
ENSG00000102144 PGK1 tumors 28423608
ENSG00000102144 PGK1 tumor 28457968
ENSG00000102144 PGK1 brain tumor 28486006
ENSG00000102144 PGK1 tumor 28559386
ENSG00000102144 PGK1 cancer 28618048
ENSG00000102144 PGK1 cancers 28686225
ENSG00000102144 PGK1 tumor 28749413
ENSG00000102144 PGK1 liver cancer 28763863
ENSG00000102144 PGK1 tumor 28903403
ENSG00000102144 PGK1 Lung Cancer 28923857
ENSG00000102144 PGK1 GBM 28994107
ENSG00000102144 PGK1 tumor 29285267
ENSG00000102144 PGK1 tumors 29414985
ENSG00000102144 PGK1 endometrial cancer 29416645
ENSG00000102144 PGK1 cancer 29900122
ENSG00000102144 PGK1 cancer 29915691
ENSG00000102144 PGK1 tumor 29926631
ENSG00000102144 PGK1 prostate cancer 29954422
ENSG00000102144 PGK1 cancer 29995887
ENSG00000102144 PGK1 tumor 30029001
ENSG00000102144 PGK1 tumor 30185791
ENSG00000102144 PGK1 tumour 30216660
ENSG00000102144 PGK1 tumor 30301907
ENSG00000102144 PGK1 cancer 30367676
ENSG00000102144 PGK1 tumor 30392930
ENSG00000102144 PGK1 gastric cancer 30420909
ENSG00000102144 PGK1 non-small cell lung cancer 30471866
ENSG00000102144 PGK1 Breast Cancer 30537744
ENSG00000102144 PGK1 endometrial cancer 30679932
ENSG00000102144 PGK1 tumor 30770778
ENSG00000102144 PGK1 cancer 30925862
ENSG00000102144 PGK1 colorectal cancer 30932211
ENSG00000102144 PGK1 gallbladder cancer 30953511
ENSG00000102144 PGK1 tumor 31114342
ENSG00000102144 PGK1 breast cancer 31148343
ENSG00000102144 PGK1 tumor 31154896
ENSG00000102144 PGK1 tumour 31198853
ENSG00000102144 PGK1 tumor 31222833
ENSG00000102144 PGK1 prostate cancer 31223280
ENSG00000102144 PGK1 pancreatic cancer 31255446
ENSG00000102144 PGK1 tumour 31278277
ENSG00000102144 PGK1 tumors 31326556
ENSG00000102144 PGK1 tumors 31357616
ENSG00000102144 PGK1 brain tumor 31492635
ENSG00000102144 PGK1 tumor 31578148
ENSG00000102144 PGK1 pancreatic cancer 31611300
ENSG00000102144 PGK1 tumor 31649264
ENSG00000102144 PGK1 cancer 31662796
ENSG00000102144 PGK1 tumor 31709724
ENSG00000102144 PGK1 cervical cancer 31757416
ENSG00000102144 PGK1 tumor 31797757
ENSG00000102144 PGK1 cervical cancer 31814898
ENSG00000102144 PGK1 cancer 31815035
ENSG00000102144 PGK1 pancreatic cancer 31827081
ENSG00000102144 PGK1 tumor 31911580
ENSG00000102144 PGK1 cancers 31949623
ENSG00000102144 PGK1 Skin tumors 3455737
ENSG00000102144 PGK1 tumors 3855474
ENSG00000102144 PGK1 tumour 6197985
ENSG00000102144 PGK1 tumor 9629891
ENSG00000102144 PGK1 tumor 9692838
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000102144 PGK1 SARC 0.00024 high
ENSG00000102144 PGK1 STAD 0.01 low
ENSG00000102144 PGK1 UVM 0.015 high
ENSG00000102144 PGK1 PAAD 0.00068 high
ENSG00000102144 PGK1 THCA 0.00067 high
ENSG00000102144 PGK1 LGG 0.0043 high
ENSG00000102144 PGK1 LUAD 0.0029 high
ENSG00000102144 PGK1 UCS 0.041 high
ENSG00000102144 PGK1 ESCA 0.00046 high
ENSG00000102144 PGK1 OV 0.049 low
ENSG00000102144 PGK1 PRAD 0.041 high
ENSG00000102144 PGK1 BLCA 0.025 high
ENSG00000102144 PGK1 LAML 0.008 high
ENSG00000102144 PGK1 LIHC 0.00028 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency