Ensembl ID ENSG00000101444 Gene ID 191 Accession 343
Gene Symbol AHCY Alias SAHH;adoHcyase Full Name adenosylhomocysteinase
Position 20 : 34280268 - 34311802 Length 31535 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

ENSG00000101444 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000101444 AHCY 0.82 2.46e-34 BRCA
ENSG00000101444 AHCY 1.63 2.43e-32 COAD
ENSG00000101444 AHCY 1.73 1.20e-11 READ
ENSG00000101444 AHCY 1.66 8.83e-54 LUSC
ENSG00000101444 AHCY 1.05 1.02e-22 UCEC
ENSG00000101444 AHCY 0.93 1.30e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000101444 AHCY ovarian cancer 16030107
ENSG00000101444 AHCY colon cancer 16598758
ENSG00000101444 AHCY tumors 18713839
ENSG00000101444 AHCY tumors 18851746
ENSG00000101444 AHCY tumor 19186948
ENSG00000101444 AHCY colon cancer 21220475
ENSG00000101444 AHCY malignant brain tumor 22192797
ENSG00000101444 AHCY cancer 23079506
ENSG00000101444 AHCY cancer 23353701
ENSG00000101444 AHCY cancer 23994169
ENSG00000101444 AHCY breast cancer 24330829
ENSG00000101444 AHCY cancers 24852755
ENSG00000101444 AHCY cancer 25255316
ENSG00000101444 AHCY breast cancer 25359765
ENSG00000101444 AHCY tumors 25477524
ENSG00000101444 AHCY tumour 27041671
ENSG00000101444 AHCY cancer 27347216
ENSG00000101444 AHCY pancreatic cancer 27624777
ENSG00000101444 AHCY tumor 27876123
ENSG00000101444 AHCY cancer 28533090
ENSG00000101444 AHCY prostate cancer 28705714
ENSG00000101444 AHCY tumor 29207610
ENSG00000101444 AHCY tumors 29472622
ENSG00000101444 AHCY cancer 30228286
ENSG00000101444 AHCY cancer 30853913
ENSG00000101444 AHCY cancer 30854431
ENSG00000101444 AHCY cancer 31265905
ENSG00000101444 AHCY breast cancer 31340867
ENSG00000101444 AHCY tumour 3743383
ENSG00000101444 AHCY tumor 8054704
ENSG00000101444 AHCY tumor 8866660
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000101444 AHCY SARC 4e-04 high
ENSG00000101444 AHCY UVM 0.024 high
ENSG00000101444 AHCY PAAD 0.05 high
ENSG00000101444 AHCY UCEC 0.0086 high
ENSG00000101444 AHCY THCA 0.021 high
ENSG00000101444 AHCY LGG 0.0011 high
ENSG00000101444 AHCY LUSC 0.036 low
ENSG00000101444 AHCY HNSC 0.032 high
ENSG00000101444 AHCY READ 0.021 low
ENSG00000101444 AHCY KIRP 0.0077 high
ENSG00000101444 AHCY KICH 0.0022 high
ENSG00000101444 AHCY THYM 0.0034 high
ENSG00000101444 AHCY ESCA 0.0029 high
ENSG00000101444 AHCY DLBC 0.026 low
ENSG00000101444 AHCY KIRC 0.024 low
ENSG00000101444 AHCY BLCA 0.0015 high
ENSG00000101444 AHCY LAML 0.0089 high
ENSG00000101444 AHCY SKCM 0.0018 high
ENSG00000101444 AHCY LIHC 0.0018 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000101444 AHCY CESC Amp 2.211511 0.186081 0.689969 0.440678
ENSG00000101444 AHCY READ Amp 19.972553 0.678520 1.317259 0.884848
ENSG00000101444 AHCY COAD Amp 34.145583 0.449715 1.156265 0.720621
ENSG00000101444 AHCY UCS Amp 1.121247 0.564947 0.809554 0.732143
ENSG00000101444 AHCY HNSC Amp 4.681317 0.197986 0.591451 0.434866
ENSG00000101444 AHCY BLCA Amp 2.244532 0.216961 0.561926 0.627451
ENSG00000101444 AHCY UCEC Amp 0.610137 0.100174 0.606669 0.261596