Ensembl ID ENSG00000100902 Gene ID 5687 Accession 9535
Gene Symbol PSMA6 Alias IOTA;p27K;PROS27 Full Name proteasome 20S subunit alpha 6
Position 14 : 35278633 - 35317493 Length 38861 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

ENSG00000100902 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000100902 0.66 1.67e-32 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000100902 tumor 16317774
ENSG00000100902 AML-M5 19840444
ENSG00000100902 tumor 24700748
ENSG00000100902 tumors 27966459
ENSG00000100902 lung cancer 28165654
ENSG00000100902 cancer 30548853
ENSG00000100902 pancreatic cancer 30898113
ENSG00000100902 malignant tumors 9654195
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000100902 MESO 0.017 low
ENSG00000100902 SARC 0.0034 high
ENSG00000100902 STAD 0.05 low
ENSG00000100902 CHOL 0.033 low
ENSG00000100902 UVM 0.00027 high
ENSG00000100902 PAAD 0.00091 high
ENSG00000100902 UCEC 0.048 high
ENSG00000100902 ACC 0.0075 high
ENSG00000100902 HNSC 0.00051 high
ENSG00000100902 READ 0.041 low
ENSG00000100902 PCPG 0.00056 low
ENSG00000100902 THYM 0.028 low
ENSG00000100902 BRCA 0.0083 high
ENSG00000100902 COAD 0.042 low
ENSG00000100902 OV 0.00017 low
ENSG00000100902 DLBC 0.038 low
ENSG00000100902 KIRC 0.0034 low
ENSG00000100902 BLCA 0.046 high
ENSG00000100902 LIHC 0.034 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000100902 LUAD Amp 43.830429 0.622138 0.825966 0.428295
ENSG00000100902 ACC Amp 0.653068 0.241263 1.170758 0.266667
ENSG00000100902 GBM Del 3.457548 0.080495 0.599187 0.291161
ENSG00000100902 BRCA Amp 1.497928 0.161434 0.578002 0.203704