Ensembl ID ENSG00000100650 Gene ID 6430 Accession 10787
Gene Symbol SRSF5 Alias HRS;SFRS5;SRP40 Full Name serine and arginine rich splicing factor 5
Position 14 : 69726900 - 69772005 Length 45106 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

ENSG00000100650 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000100650 SRSF5 -0.7 1.15e-35 BRCA
ENSG00000100650 SRSF5 -0.6 3.45e-17 COAD
ENSG00000100650 SRSF5 -0.5 9.39e-15 LUSC
ENSG00000100650 SRSF5 -0.4 2.82e-13 LIHC
ENSG00000100650 SRSF5 -0.8 9.03e-26 STAD
ENSG00000100650 SRSF5 -0.7 4.14e-23 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000100650 SRSF5 AML 22722453
ENSG00000100650 SRSF5 Cancer 23284704
ENSG00000100650 SRSF5 gastric cancer 27282379
ENSG00000100650 SRSF5 small-cell lung cancer 27565915
ENSG00000100650 SRSF5 testicular germ cell tumors 28536481
ENSG00000100650 SRSF5 HNSCCs 28843252
ENSG00000100650 SRSF5 tumor 29857020
ENSG00000100650 SRSF5 tumor 29942010
ENSG00000100650 SRSF5 small-cell lung cancer 31106485
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000100650 SRSF5 MESO 0.0028 low
ENSG00000100650 SRSF5 PAAD 0.0026 low
ENSG00000100650 SRSF5 LGG 0.001 low
ENSG00000100650 SRSF5 HNSC 0.02 low
ENSG00000100650 SRSF5 KIRP 0.041 low
ENSG00000100650 SRSF5 BRCA 0.00096 low
ENSG00000100650 SRSF5 PRAD 0.0068 high
ENSG00000100650 SRSF5 BLCA 0.0063 low
ENSG00000100650 SRSF5 SKCM 0.00011 low
ENSG00000100650 SRSF5 CESC 0.0012 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000100650 SRSF5 CHOL Del 2.183484 0.330810 0.607863 0.583333
ENSG00000100650 SRSF5 LGG Del 10.545452 0.107210 0.544765 0.231969
ENSG00000100650 SRSF5 SARC Del 1.464619 0.144072 0.574859 0.311284
ENSG00000100650 SRSF5 GBM Del 2.867249 0.075429 0.595787 0.296360
ENSG00000100650 SRSF5 LIHC Del 3.223193 0.101535 0.515590 0.343243
ENSG00000100650 SRSF5 BRCA Del 6.999397 0.102250 0.423336 0.329630
ENSG00000100650 SRSF5 KIRC Del 0.667893 0.023991 0.427167 0.429924
ENSG00000100650 SRSF5 OV Del 5.271052 0.250001 0.540774 0.516408