Ensembl ID ENSG00000100412 Gene ID 50 Accession 118
Gene Symbol ACO2 Alias ICRD;OCA8;OPA9;ACONM;HEL-S-284 Full Name aconitase 2
Position 22 : 41447830 - 41529273 Length 81444 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]

ENSG00000100412 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000100412 ACO2 -0.6 7.50e-11 KIRC
ENSG00000100412 ACO2 -1.0 5.16e-27 HNSC
ENSG00000100412 ACO2 -1.1 2.66e-29 COAD
ENSG00000100412 ACO2 1.37 1.71e-22 KICH
ENSG00000100412 ACO2 -1.0 7.42e-21 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000100412 ACO2 colorectal cancer 12746427
ENSG00000100412 ACO2 cancer 22166000
ENSG00000100412 ACO2 gastric cancer 23550275
ENSG00000100412 ACO2 tumor 28606997
ENSG00000100412 ACO2 prostate cancer 29563510
ENSG00000100412 ACO2 prostate cancer 30167092
ENSG00000100412 ACO2 prostate cancer 30972978
ENSG00000100412 ACO2 kidney cancer 31814027
ENSG00000100412 ACO2 cancer 31819175
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000100412 ACO2 MESO 0.0056 low
ENSG00000100412 ACO2 STAD 0.017 low
ENSG00000100412 ACO2 UVM 0.00048 high
ENSG00000100412 ACO2 PAAD 0.018 high
ENSG00000100412 ACO2 ACC 0.0017 low
ENSG00000100412 ACO2 READ 0.014 low
ENSG00000100412 ACO2 KIRP 0.00072 low
ENSG00000100412 ACO2 KICH 0.001 high
ENSG00000100412 ACO2 LUAD 3e-04 high
ENSG00000100412 ACO2 THYM 0.037 high
ENSG00000100412 ACO2 ESCA 0.012 high
ENSG00000100412 ACO2 OV 0.024 high
ENSG00000100412 ACO2 BLCA 0.023 high
ENSG00000100412 ACO2 LAML 0.0025 high
ENSG00000100412 ACO2 GBM 0.042 low
ENSG00000100412 ACO2 SKCM 0.00016 high
ENSG00000100412 ACO2 CESC 0.019 low
ENSG00000100412 ACO2 LIHC 0.0089 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000100412 ACO2 GBM Del 1.100946 0.057228 0.584140 0.344887
ENSG00000100412 ACO2 SKCM Amp 6.939967 0.289815 0.692640 0.403270
ENSG00000100412 ACO2 PCPG Del 0.827675 0.060816 0.622000 0.395062
ENSG00000100412 ACO2 BLCA Del 1.058503 0.083587 0.364337 0.450980
ENSG00000100412 ACO2 UCEC Del 1.431292 0.057246 0.559647 0.226345
ENSG00000100412 ACO2 OV Del 4.303478 0.237846 0.654501 0.820380