Ensembl ID ENSG00000099942 Gene ID 1399 Accession 2363
Gene Symbol CRKL Alias NA Full Name CRK like proto-oncogene, adaptor protein
Position 22 : 20917407 - 20953747 Length 36341 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

ENSG00000099942 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000099942 CRKL 0.88 1.80e-19 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000099942 CRKL tumors 19091943
ENSG00000099942 CRKL tumor 19168626
ENSG00000099942 CRKL lung cancer 19966867
ENSG00000099942 CRKL prostate cancer 20688158
ENSG00000099942 CRKL tumors 21676433
ENSG00000099942 CRKL laryngeal cancer 21896986
ENSG00000099942 CRKL lung cancer 22211192
ENSG00000099942 CRKL hematopoietic tumors 22244889
ENSG00000099942 CRKL gastric cancer 22383989
ENSG00000099942 CRKL non-small cell lung cancers 22586683
ENSG00000099942 CRKL gastric cancer 22591714
ENSG00000099942 CRKL small cell lung cancer 22736441
ENSG00000099942 CRKL non-small cell lung cancer 22753141
ENSG00000099942 CRKL tumor 23318429
ENSG00000099942 CRKL cancer 23397142
ENSG00000099942 CRKL breast cancer 23686806
ENSG00000099942 CRKL gastric cancer 24055140
ENSG00000099942 CRKL cancer 24110284
ENSG00000099942 CRKL bladder cancer 24375195
ENSG00000099942 CRKL colon cancer 24389200
ENSG00000099942 CRKL lung cancer 24664993
ENSG00000099942 CRKL metastatic cancer 24805778
ENSG00000099942 CRKL breast cancer 24913448
ENSG00000099942 CRKL lung cancers 24939008
ENSG00000099942 CRKL pancreatic cancer 25318601
ENSG00000099942 CRKL breast cancer 25405387
ENSG00000099942 CRKL tumor 25531052
ENSG00000099942 CRKL cancer 25540073
ENSG00000099942 CRKL tumour 25661331
ENSG00000099942 CRKL pancreatic cancer 25897431
ENSG00000099942 CRKL tumor 25960220
ENSG00000099942 CRKL cancer 26079153
ENSG00000099942 CRKL tumor 26728244
ENSG00000099942 CRKL cancer 26756996
ENSG00000099942 CRKL lung cancer 26758680
ENSG00000099942 CRKL cervical cancer 27133071
ENSG00000099942 CRKL cancer 27686861
ENSG00000099942 CRKL tumor 27846244
ENSG00000099942 CRKL tumor 28029654
ENSG00000099942 CRKL tumor 28123521
ENSG00000099942 CRKL gastric cancer 28239297
ENSG00000099942 CRKL gastric cancer 28255248
ENSG00000099942 CRKL breast cancer 28392847
ENSG00000099942 CRKL cancer 28436261
ENSG00000099942 CRKL acute myeloid leukemia (AML) 28549153
ENSG00000099942 CRKL tumor 28558797
ENSG00000099942 CRKL Cancer 28723560
ENSG00000099942 CRKL cancer 28887306
ENSG00000099942 CRKL breast cancer 29155146
ENSG00000099942 CRKL Cervical Cancer 29295725
ENSG00000099942 CRKL lung cancer 29344280
ENSG00000099942 CRKL ovarian cancer 29344361
ENSG00000099942 CRKL tumor 29403024
ENSG00000099942 CRKL tumor 29409051
ENSG00000099942 CRKL cancer 30015845
ENSG00000099942 CRKL Tumor 30480076
ENSG00000099942 CRKL ER+ breast cancers 30914635
ENSG00000099942 CRKL bladder cancer 30964165
ENSG00000099942 CRKL cervical tumor 31133010
ENSG00000099942 CRKL breast cancer 31323992
ENSG00000099942 CRKL tumor 31610796
ENSG00000099942 CRKL Colorectal Cancer 31755734
ENSG00000099942 CRKL tumors 31913340
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000099942 CRKL SARC 0.0013 high
ENSG00000099942 CRKL STAD 0.032 low
ENSG00000099942 CRKL UVM 0.039 low
ENSG00000099942 CRKL UCEC 0.02 high
ENSG00000099942 CRKL ACC 0.0046 high
ENSG00000099942 CRKL LUSC 0.036 low
ENSG00000099942 CRKL READ 0.0011 low
ENSG00000099942 CRKL KIRP 9e-04 high
ENSG00000099942 CRKL KICH 0.00027 high
ENSG00000099942 CRKL LUAD 0.019 high
ENSG00000099942 CRKL PCPG 0.0028 low
ENSG00000099942 CRKL THYM 0.0089 low
ENSG00000099942 CRKL ESCA 0.017 low
ENSG00000099942 CRKL KIRC 0.0069 low
ENSG00000099942 CRKL PRAD 0.028 high
ENSG00000099942 CRKL BLCA 0.002 low
ENSG00000099942 CRKL LAML 0.032 high
ENSG00000099942 CRKL GBM 0.013 low
ENSG00000099942 CRKL SKCM 0.011 high
ENSG00000099942 CRKL LIHC 0.022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency