Ensembl ID ENSG00000099860 Gene ID 4616 Accession 4096
Gene Symbol GADD45B Alias MYD118;GADD45BETA Full Name growth arrest and DNA damage inducible beta
Position 19 : 2476127 - 2478257 Length 2131 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

ENSG00000099860 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000099860 GADD45B -1.8 1.14e-33 HNSC
ENSG00000099860 GADD45B -2.7 2.42e-19 BLCA
ENSG00000099860 GADD45B -2.7 1.78e-74 LUSC
ENSG00000099860 GADD45B -1.9 2.39e-26 LIHC
ENSG00000099860 GADD45B -2.2 6.07e-31 STAD
ENSG00000099860 GADD45B -2.6 5.83e-15 CHOL
ENSG00000099860 GADD45B -1.7 3.62e-39 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000099860 GADD45B tumor 12579308
ENSG00000099860 GADD45B tumors 15520179
ENSG00000099860 GADD45B pituitary tumor 17728792
ENSG00000099860 GADD45B prostate cancer 17878531
ENSG00000099860 GADD45B tumor 18248671
ENSG00000099860 GADD45B tumor 20038200
ENSG00000099860 GADD45B ovarian cancer 20386703
ENSG00000099860 GADD45B tumors 20652500
ENSG00000099860 GADD45B colon cancer 21176237
ENSG00000099860 GADD45B tumor 23110778
ENSG00000099860 GADD45B tumor 23616123
ENSG00000099860 GADD45B tumor 24190252
ENSG00000099860 GADD45B prostate cancer 24708576
ENSG00000099860 GADD45B tumor 24990820
ENSG00000099860 GADD45B tumor 25314077
ENSG00000099860 GADD45B cancer 26568413
ENSG00000099860 GADD45B non-small cell lung cancer 26993769
ENSG00000099860 GADD45B germ cell cancers 27572311
ENSG00000099860 GADD45B tumor 28052097
ENSG00000099860 GADD45B tumor 28751557
ENSG00000099860 GADD45B lung cancer 28870783
ENSG00000099860 GADD45B tumor 28900541
ENSG00000099860 GADD45B ovarian cancer 29170526
ENSG00000099860 GADD45B cancers 29279355
ENSG00000099860 GADD45B prostate cancer 29356020
ENSG00000099860 GADD45B prostate cancer 29629343
ENSG00000099860 GADD45B Cancer 29716964
ENSG00000099860 GADD45B endometrial cancer 29760790
ENSG00000099860 GADD45B tumor 30029519
ENSG00000099860 GADD45B lung cancer 30250533
ENSG00000099860 GADD45B non-small cell lung cancer 31296259
ENSG00000099860 GADD45B tumor 31351327
ENSG00000099860 GADD45B cancer 31681565
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000099860 GADD45B MESO 0.014 high
ENSG00000099860 GADD45B SARC 0.0034 low
ENSG00000099860 GADD45B STAD 0.0014 high
ENSG00000099860 GADD45B UVM 0.035 high
ENSG00000099860 GADD45B THCA 0.01 high
ENSG00000099860 GADD45B ACC 0.023 high
ENSG00000099860 GADD45B LGG 0.016 high
ENSG00000099860 GADD45B LUSC 0.0014 high
ENSG00000099860 GADD45B HNSC 0.027 high
ENSG00000099860 GADD45B READ 0.015 high
ENSG00000099860 GADD45B KICH 0.0042 low
ENSG00000099860 GADD45B COAD 0.023 high
ENSG00000099860 GADD45B ESCA 0.00023 high
ENSG00000099860 GADD45B OV 0.0086 high
ENSG00000099860 GADD45B DLBC 0.038 low
ENSG00000099860 GADD45B KIRC 0.0048 high
ENSG00000099860 GADD45B PRAD 0.0014 high
ENSG00000099860 GADD45B TGCT 0.037 high
ENSG00000099860 GADD45B BLCA 0.015 high
ENSG00000099860 GADD45B SKCM 0.0011 low
ENSG00000099860 GADD45B LIHC 0.00014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000099860 GADD45B LUSC Del 6.205780 0.123392 0.352069 0.449102
ENSG00000099860 GADD45B LUAD Del 4.007851 0.085185 0.352625 0.540698
ENSG00000099860 GADD45B CESC Del 10.984437 0.184601 0.482158 0.328814
ENSG00000099860 GADD45B READ Del 0.637830 0.068240 0.347884 0.212121
ENSG00000099860 GADD45B COAD Del 1.311136 0.049211 0.384295 0.130820
ENSG00000099860 GADD45B UCS Del 12.219189 0.788788 0.621884 0.803571
ENSG00000099860 GADD45B SARC Del 1.806910 0.152498 0.436141 0.198444
ENSG00000099860 GADD45B PAAD Del 1.826614 0.067666 0.355841 0.190217
ENSG00000099860 GADD45B ESCA Del 3.389873 0.165339 0.344072 0.489130
ENSG00000099860 GADD45B THCA Del 0.928265 0.010197 0.678144 0.014028
ENSG00000099860 GADD45B HNSC Del 12.142416 0.132946 0.356124 0.314176
ENSG00000099860 GADD45B LIHC Del 5.514666 0.126699 0.460643 0.240541
ENSG00000099860 GADD45B BLCA Del 4.052551 0.123656 0.332903 0.348039
ENSG00000099860 GADD45B BRCA Del 21.131935 0.151972 0.394311 0.314815
ENSG00000099860 GADD45B STAD Del 2.065152 0.079296 0.352139 0.358277
ENSG00000099860 GADD45B UCEC Del 46.426504 0.270562 0.600875 0.285714
ENSG00000099860 GADD45B OV Del 132.338436 0.925021 0.654735 0.884283