Ensembl ID ENSG00000099817 Gene ID 5434 Accession 9192
Gene Symbol POLR2E Alias RPB5;XAP4;RPABC1;hRPB25;hsRPB5 Full Name RNA polymerase II, I and III subunit E
Position 19 : 1086574 - 1095380 Length 8807 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

ENSG00000099817 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000099817 POLR2E 0.66 5.48e-17 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000099817 POLR2E tumors 25676555
ENSG00000099817 POLR2E esophageal cancer 25874495
ENSG00000099817 POLR2E cancer 28159929
ENSG00000099817 POLR2E cancer 29724531
ENSG00000099817 POLR2E Prostate Cancer 29922603
ENSG00000099817 POLR2E cancer 30291213
ENSG00000099817 POLR2E prostate cancer 30587086
ENSG00000099817 POLR2E cancer 30846411
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000099817 POLR2E UVM 0.0083 high
ENSG00000099817 POLR2E PAAD 0.0024 low
ENSG00000099817 POLR2E UCEC 0.013 low
ENSG00000099817 POLR2E THCA 0.0012 low
ENSG00000099817 POLR2E LGG 0.00042 high
ENSG00000099817 POLR2E KIRP 0.001 low
ENSG00000099817 POLR2E BRCA 0.023 low
ENSG00000099817 POLR2E ESCA 0.013 low
ENSG00000099817 POLR2E DLBC 0.019 low
ENSG00000099817 POLR2E KIRC 0.00024 low
ENSG00000099817 POLR2E BLCA 0.00081 high
ENSG00000099817 POLR2E LIHC 0.004 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000099817 POLR2E LUSC Del 10.405106 0.152781 0.361163 0.465070
ENSG00000099817 POLR2E LUAD Del 4.242222 0.087074 0.352434 0.531008
ENSG00000099817 POLR2E CESC Del 17.339598 0.234880 0.505170 0.355932
ENSG00000099817 POLR2E READ Del 0.637830 0.068240 0.352942 0.206061
ENSG00000099817 POLR2E COAD Del 3.256303 0.067456 0.404187 0.135255
ENSG00000099817 POLR2E UCS Del 12.047777 0.777188 0.618830 0.821429
ENSG00000099817 POLR2E SARC Del 4.284623 0.204313 0.474725 0.233463
ENSG00000099817 POLR2E PAAD Del 1.885596 0.068842 0.357320 0.190217
ENSG00000099817 POLR2E ESCA Del 3.964775 0.177696 0.354083 0.505435
ENSG00000099817 POLR2E SKCM Del 1.866476 0.084665 0.345614 0.283379
ENSG00000099817 POLR2E HNSC Del 16.388159 0.154309 0.363668 0.331418
ENSG00000099817 POLR2E LIHC Del 6.995980 0.141037 0.459990 0.251351
ENSG00000099817 POLR2E BLCA Del 6.709303 0.150722 0.350319 0.345588
ENSG00000099817 POLR2E BRCA Del 29.034456 0.174327 0.408415 0.333333
ENSG00000099817 POLR2E STAD Del 2.211282 0.081260 0.355268 0.337868
ENSG00000099817 POLR2E UCEC Del 41.255637 0.251078 0.584038 0.263451
ENSG00000099817 POLR2E OV Del 135.799316 0.939045 0.652468 0.882556