Ensembl ID ENSG00000096433 Gene ID 3710 Accession 6182
Gene Symbol ITPR3 Alias IP3R;CMT1J;IP3R3 Full Name inositol 1,4,5-trisphosphate receptor type 3
Position 6 : 33620365 - 33696574 Length 76210 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

ENSG00000096433 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000096433 ITPR3 0.94 3.79e-13 HNSC
ENSG00000096433 ITPR3 0.74 6.39e-20 BRCA
ENSG00000096433 ITPR3 1.54 2.33e-15 UCEC
ENSG00000096433 ITPR3 3.50 2.75e-31 CHOL
ENSG00000096433 ITPR3 3.36 6.10e-11 CESC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000096433 ITPR3 gastric cancers 14619519
ENSG00000096433 ITPR3 gastric cancers 14666665
ENSG00000096433 ITPR3 tumor 18698039
ENSG00000096433 ITPR3 cancer 23681227
ENSG00000096433 ITPR3 breast cancer 23992640
ENSG00000096433 ITPR3 breast cancer 25941664
ENSG00000096433 ITPR3 tumors 26619122
ENSG00000096433 ITPR3 cervical cancer 28036301
ENSG00000096433 ITPR3 breast cancer 28072864
ENSG00000096433 ITPR3 colorectal cancer 28119804
ENSG00000096433 ITPR3 colon cancer 28448473
ENSG00000096433 ITPR3 cancer 28614300
ENSG00000096433 ITPR3 breast cancer 28725634
ENSG00000096433 ITPR3 colorectal cancer 28944215
ENSG00000096433 ITPR3 breast cancer 29069790
ENSG00000096433 ITPR3 cancer 29491433
ENSG00000096433 ITPR3 gastric cancer 29492218
ENSG00000096433 ITPR3 Cancer 29618618
ENSG00000096433 ITPR3 tumor 29626751
ENSG00000096433 ITPR3 breast cancer 29630900
ENSG00000096433 ITPR3 tumor 30042492
ENSG00000096433 ITPR3 cancer 30796197
ENSG00000096433 ITPR3 colorectal cancer 30877106
ENSG00000096433 ITPR3 cancer 31225437
ENSG00000096433 ITPR3 liver cancer 31315892
ENSG00000096433 ITPR3 cancer 31865041
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000096433 ITPR3 MESO 0.01 low
ENSG00000096433 ITPR3 STAD 0.043 low
ENSG00000096433 ITPR3 CHOL 0.015 low
ENSG00000096433 ITPR3 PAAD 2e-04 high
ENSG00000096433 ITPR3 ACC 0.048 low
ENSG00000096433 ITPR3 LGG 0.0026 high
ENSG00000096433 ITPR3 READ 0.00023 low
ENSG00000096433 ITPR3 ESCA 0.036 low
ENSG00000096433 ITPR3 OV 0.026 high
ENSG00000096433 ITPR3 KIRC 0.039 low
ENSG00000096433 ITPR3 PRAD 0.024 high
ENSG00000096433 ITPR3 BLCA 0.026 low
ENSG00000096433 ITPR3 LAML 0.018 high
ENSG00000096433 ITPR3 GBM 0.031 high
ENSG00000096433 ITPR3 CESC 0.021 high
ENSG00000096433 ITPR3 LIHC 0.0017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000096433 ITPR3 SKCM Amp 1.125791 0.134297 0.722944 0.509537
ENSG00000096433 ITPR3 UVM Amp 1.872709 0.238074 1.140112 0.537500
ENSG00000096433 ITPR3 OV Amp 0.611831 0.322699 0.673845 0.449050