Ensembl ID ENSG00000093167 Gene ID 9209 Accession 6703
Gene Symbol LRRFIP2 Alias HUFI-2 Full Name LRR binding FLII interacting protein 2
Position 3 : 37052626 - 37176532 Length 123907 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

ENSG00000093167 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000093167 LRRFIP2 -0.7 9.99e-23 HNSC
ENSG00000093167 LRRFIP2 -0.8 1.52e-31 COAD
ENSG00000093167 LRRFIP2 -0.4 3.16e-12 LUSC
ENSG00000093167 LRRFIP2 1.07 1.10e-20 KIRP
ENSG00000093167 LRRFIP2 -1.1 3.03e-14 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000093167 LRRFIP2 tumor 18353764
ENSG00000093167 LRRFIP2 cancer 26895224
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000093167 LRRFIP2 MESO 0.0098 high
ENSG00000093167 LRRFIP2 STAD 0.033 low
ENSG00000093167 LRRFIP2 UVM 0.0023 low
ENSG00000093167 LRRFIP2 PAAD 0.0061 high
ENSG00000093167 LRRFIP2 THCA 0.0049 high
ENSG00000093167 LRRFIP2 ACC 0.013 high
ENSG00000093167 LRRFIP2 LGG 0.0059 low
ENSG00000093167 LRRFIP2 HNSC 0.037 low
ENSG00000093167 LRRFIP2 READ 0.0081 low
ENSG00000093167 LRRFIP2 KIRP 0.0097 low
ENSG00000093167 LRRFIP2 KICH 0.002 high
ENSG00000093167 LRRFIP2 PCPG 0.013 low
ENSG00000093167 LRRFIP2 BRCA 0.0015 low
ENSG00000093167 LRRFIP2 COAD 0.027 low
ENSG00000093167 LRRFIP2 ESCA 0.026 high
ENSG00000093167 LRRFIP2 OV 0.021 low
ENSG00000093167 LRRFIP2 KIRC 0.019 high
ENSG00000093167 LRRFIP2 BLCA 0.035 high
ENSG00000093167 LRRFIP2 CESC 0.0018 low
ENSG00000093167 LRRFIP2 LIHC 0.0039 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000093167 LRRFIP2 CHOL Del 0.615751 0.195478 0.623221 0.805556
ENSG00000093167 LRRFIP2 BRCA Del 3.339024 0.083504 0.431608 0.239815
ENSG00000093167 LRRFIP2 STAD Del 2.539091 0.084943 0.337102 0.306122
ENSG00000093167 LRRFIP2 MESO Del 4.470511 0.253863 0.594488 0.252874
ENSG00000093167 LRRFIP2 KIRC Del 48.040933 0.172240 0.516761 0.880682