Ensembl ID ENSG00000092847 Gene ID 26523 Accession 3262
Gene Symbol AGO1 Alias Q99;EIF2C;hAgo1;EIF2C1;GERP95;NEDLBAS Full Name argonaute RISC component 1
Position 1 : 35869808 - 35930532 Length 60725 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

ENSG00000092847 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000092847 AGO1 tumor 16936726
ENSG00000092847 AGO1 colon cancer 20146808
ENSG00000092847 AGO1 lung cancer 20721975
ENSG00000092847 AGO1 cancer 21692980
ENSG00000092847 AGO1 breast cancer 21766210
ENSG00000092847 AGO1 skin cancer 22025453
ENSG00000092847 AGO1 cancer 23426184
ENSG00000092847 AGO1 colon cancer 23939471
ENSG00000092847 AGO1 tumor 26588727
ENSG00000092847 AGO1 tumors 27518285
ENSG00000092847 AGO1 cancer 27639690
ENSG00000092847 AGO1 Lung Cancer 27669275
ENSG00000092847 AGO1 gastric cancer 27685626
ENSG00000092847 AGO1 gastric cancer 29156806
ENSG00000092847 AGO1 tumors 29487329
ENSG00000092847 AGO1 bladder cancer 29857476
ENSG00000092847 AGO1 breast cancer 30284063
ENSG00000092847 AGO1 cancer 30356106
ENSG00000092847 AGO1 cancer 30858133
ENSG00000092847 AGO1 tumor 31064890
ENSG00000092847 AGO1 cancer 31494269
ENSG00000092847 AGO1 tumor 31510013
ENSG00000092847 AGO1 cancer 31616639
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000092847 AGO1 SARC 0.015 high
ENSG00000092847 AGO1 STAD 0.018 low
ENSG00000092847 AGO1 UVM 0.0028 low
ENSG00000092847 AGO1 UCEC 0.012 high
ENSG00000092847 AGO1 LGG 0.005 high
ENSG00000092847 AGO1 READ 0.003 low
ENSG00000092847 AGO1 KICH 0.00027 high
ENSG00000092847 AGO1 LUAD 0.003 low
ENSG00000092847 AGO1 COAD 0.021 high
ENSG00000092847 AGO1 ESCA 0.0098 low
ENSG00000092847 AGO1 OV 0.0011 high
ENSG00000092847 AGO1 BLCA 0.0048 high
ENSG00000092847 AGO1 CESC 0.041 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000092847 AGO1 CHOL Del 4.571165 0.463134 0.602717 0.444444
ENSG00000092847 AGO1 KIRP Del 2.873165 0.047366 0.589190 0.156250
ENSG00000092847 AGO1 COAD Del 1.811992 0.054253 0.403964 0.279379
ENSG00000092847 AGO1 LIHC Del 5.279578 0.124358 0.514240 0.316216
ENSG00000092847 AGO1 PCPG Del 1.352336 0.072177 0.671612 0.617284
ENSG00000092847 AGO1 BRCA Del 1.784264 0.072979 0.386117 0.309259
ENSG00000092847 AGO1 UCEC Del 0.639988 0.046600 0.425594 0.077922
ENSG00000092847 AGO1 KIRC Del 1.452277 0.029527 0.418665 0.157197
ENSG00000092847 AGO1 UVM Del 1.628635 0.093379 0.808745 0.300000
ENSG00000092847 AGO1 OV Amp 9.271979 0.534232 0.715865 0.438687