Ensembl ID ENSG00000092621 Gene ID 26227 Accession 8923
Gene Symbol PHGDH Alias NLS;PDG;PGD;NLS1;PGAD;PGDH;SERA;3PGDH;3-PGDH;PHGDHD;HEL-S-113 Full Name phosphoglycerate dehydrogenase
Position 1 : 119648411 - 119744218 Length 95808 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

ENSG00000092621 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000092621 PHGDH -1.4 5.29e-17 KIRC
ENSG00000092621 PHGDH 1.59 1.22e-12 COAD
ENSG00000092621 PHGDH 2.45 3.25e-52 LUSC
ENSG00000092621 PHGDH -1.5 7.73e-12 LIHC
ENSG00000092621 PHGDH 1.22 6.69e-11 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000092621 PHGDH Tumor 10652389
ENSG00000092621 PHGDH cancer 10713460
ENSG00000092621 PHGDH tumours 1162747
ENSG00000092621 PHGDH cancer 1189349
ENSG00000092621 PHGDH tumor 122901
ENSG00000092621 PHGDH tumour 1360622
ENSG00000092621 PHGDH tumour 15726365
ENSG00000092621 PHGDH tumor 1587826
ENSG00000092621 PHGDH Lung cancer 15881660
ENSG00000092621 PHGDH lung cancer 16143346
ENSG00000092621 PHGDH tumor 176382
ENSG00000092621 PHGDH lung cancer 18569708
ENSG00000092621 PHGDH tumour 18644147
ENSG00000092621 PHGDH tumor 19118015
ENSG00000092621 PHGDH breast cancer 19121212
ENSG00000092621 PHGDH breast cancer 20352489
ENSG00000092621 PHGDH breast cancer 21437235
ENSG00000092621 PHGDH breast cancer 21760589
ENSG00000092621 PHGDH cancer 21804546
ENSG00000092621 PHGDH cancer 21981974
ENSG00000092621 PHGDH tumours 222026
ENSG00000092621 PHGDH cancer 22330683
ENSG00000092621 PHGDH cancer 22498977
ENSG00000092621 PHGDH cancer 22988443
ENSG00000092621 PHGDH tumor 23229761
ENSG00000092621 PHGDH intestinal tumors 23374352
ENSG00000092621 PHGDH prostate cancer 23389923
ENSG00000092621 PHGDH tumour 23604405
ENSG00000092621 PHGDH cancers 24186203
ENSG00000092621 PHGDH tumor 24212716
ENSG00000092621 PHGDH cervical cancer 24247658
ENSG00000092621 PHGDH tumor 24318446
ENSG00000092621 PHGDH triple negative breast cancer 24390667
ENSG00000092621 PHGDH tumor 24496750
ENSG00000092621 PHGDH Cancer 24657017
ENSG00000092621 PHGDH tumor 24778322
ENSG00000092621 PHGDH breast cancer 24979213
ENSG00000092621 PHGDH phyllodes tumors 25030440
ENSG00000092621 PHGDH tumor 25053597
ENSG00000092621 PHGDH tumor 25057353
ENSG00000092621 PHGDH breast cancer 25406093
ENSG00000092621 PHGDH lung cancer 25436979
ENSG00000092621 PHGDH cancer 25476909
ENSG00000092621 PHGDH breast cancer 25496516
ENSG00000092621 PHGDH cancer 25574168
ENSG00000092621 PHGDH tumor 25719555
ENSG00000092621 PHGDH breast cancer 25859558
ENSG00000092621 PHGDH cancers 25926973
ENSG00000092621 PHGDH breast cancer 25994018
ENSG00000092621 PHGDH breast cancer 26005711
ENSG00000092621 PHGDH cancer 26356530
ENSG00000092621 PHGDH breast cancer 26389003
ENSG00000092621 PHGDH tumour 26482881
ENSG00000092621 PHGDH tumor 26499495
ENSG00000092621 PHGDH breast cancer 26646448
ENSG00000092621 PHGDH tumours 26725330
ENSG00000092621 PHGDH tumor 26767003
ENSG00000092621 PHGDH cancer 26831078
ENSG00000092621 PHGDH breast cancer 27110680
ENSG00000092621 PHGDH cancer 27239443
ENSG00000092621 PHGDH tumor 27267836
ENSG00000092621 PHGDH tumor 27270434
ENSG00000092621 PHGDH tumor 27277113
ENSG00000092621 PHGDH Breast Cancer 27280394
ENSG00000092621 PHGDH colon cancer 27326252
ENSG00000092621 PHGDH breast cancer 27386546
ENSG00000092621 PHGDH tumor 27458133
ENSG00000092621 PHGDH tumor 27473325
ENSG00000092621 PHGDH breast cancer 27540483
ENSG00000092621 PHGDH breast cancer 27652319
ENSG00000092621 PHGDH tumor 27660473
ENSG00000092621 PHGDH breast cancers 27698834
ENSG00000092621 PHGDH ovarian cancer 27725832
ENSG00000092621 PHGDH breast cancer 27811150
ENSG00000092621 PHGDH Non-Small Cell Lung Cancer 27916294
ENSG00000092621 PHGDH tumors 27959531
ENSG00000092621 PHGDH tumor 28042046
ENSG00000092621 PHGDH cancer 28085281
ENSG00000092621 PHGDH cancer 28177894
ENSG00000092621 PHGDH Cancer 28332880
ENSG00000092621 PHGDH tumor 28387968
ENSG00000092621 PHGDH tumors 28413646
ENSG00000092621 PHGDH tumours 28472819
ENSG00000092621 PHGDH breast cancer 28624704
ENSG00000092621 PHGDH cancer 28649560
ENSG00000092621 PHGDH breast cancer 28652562
ENSG00000092621 PHGDH tumor 28819410
ENSG00000092621 PHGDH ovarian cancer 28857608
ENSG00000092621 PHGDH breast cancers 28931725
ENSG00000092621 PHGDH tumor 28951458
ENSG00000092621 PHGDH Cancer 28991459
ENSG00000092621 PHGDH Kidney cancer 29116254
ENSG00000092621 PHGDH pancreatic cancer 29128633
ENSG00000092621 PHGDH neuroendocrine tumors 29144820
ENSG00000092621 PHGDH cancer 29262655
ENSG00000092621 PHGDH tumors 29312889
ENSG00000092621 PHGDH cancer 29433752
ENSG00000092621 PHGDH cancer 29555419
ENSG00000092621 PHGDH tumor 29556358
ENSG00000092621 PHGDH breast cancer 29568346
ENSG00000092621 PHGDH breast cancer 29626321
ENSG00000092621 PHGDH tumor 29672864
ENSG00000092621 PHGDH cancer 29674746
ENSG00000092621 PHGDH cancer 29740540
ENSG00000092621 PHGDH tumors 29873416
ENSG00000092621 PHGDH cancer 29925909
ENSG00000092621 PHGDH Cancer 30037819
ENSG00000092621 PHGDH tumors 30079313
ENSG00000092621 PHGDH cancer 30093970
ENSG00000092621 PHGDH basal-like breast cancers 30157431
ENSG00000092621 PHGDH tumours 30176945
ENSG00000092621 PHGDH cancer 30250195
ENSG00000092621 PHGDH cancer 30410394
ENSG00000092621 PHGDH cancer 30631755
ENSG00000092621 PHGDH pancreatic cancer 30744688
ENSG00000092621 PHGDH cancers 30852233
ENSG00000092621 PHGDH breast cancer 30857125
ENSG00000092621 PHGDH tumors 3088311
ENSG00000092621 PHGDH tumor 30894617
ENSG00000092621 PHGDH tumors 30905671
ENSG00000092621 PHGDH tumor 30987822
ENSG00000092621 PHGDH tumor 31096630
ENSG00000092621 PHGDH pancreatic cancer 31112178
ENSG00000092621 PHGDH cancer 31327531
ENSG00000092621 PHGDH cancers 31331318
ENSG00000092621 PHGDH tumor 31423225
ENSG00000092621 PHGDH cancer 31615983
ENSG00000092621 PHGDH cancer 31681859
ENSG00000092621 PHGDH pancreatic cancer 31897243
ENSG00000092621 PHGDH gastric cancer 31949673
ENSG00000092621 PHGDH cancer 31979167
ENSG00000092621 PHGDH tumors 4341820
ENSG00000092621 PHGDH tumor 483683
ENSG00000092621 PHGDH cancer 483698
ENSG00000092621 PHGDH mammary cancer 518361
ENSG00000092621 PHGDH tumor 5584671
ENSG00000092621 PHGDH tumors 6144677
ENSG00000092621 PHGDH Malignant tumors 6582310
ENSG00000092621 PHGDH tumor 6640538
ENSG00000092621 PHGDH tumors 6692392
ENSG00000092621 PHGDH tumor 89649
ENSG00000092621 PHGDH mixed tumor 9807068
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000092621 PHGDH MESO 0.043 low
ENSG00000092621 PHGDH CHOL 0.044 low
ENSG00000092621 PHGDH PAAD 0.0023 high
ENSG00000092621 PHGDH LGG 0.005 low
ENSG00000092621 PHGDH LUSC 0.031 low
ENSG00000092621 PHGDH HNSC 0.016 high
ENSG00000092621 PHGDH COAD 0.0043 high
ENSG00000092621 PHGDH OV 0.015 low
ENSG00000092621 PHGDH DLBC 0.036 low
ENSG00000092621 PHGDH KIRC 0.044 high
ENSG00000092621 PHGDH PRAD 0.036 low
ENSG00000092621 PHGDH BLCA 0.0053 high
ENSG00000092621 PHGDH SKCM 0.019 low
ENSG00000092621 PHGDH LIHC 0.0093 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000092621 PHGDH LUSC Del 11.162003 0.157535 0.414635 0.377246
ENSG00000092621 PHGDH LUAD Del 9.047073 0.120644 0.356741 0.244186
ENSG00000092621 PHGDH COAD Del 0.629069 0.041290 0.401689 0.223947
ENSG00000092621 PHGDH PAAD Amp 3.628050 0.173081 0.724861 0.135870
ENSG00000092621 PHGDH ESCA Del 1.103014 0.108265 0.389523 0.266304
ENSG00000092621 PHGDH SKCM Amp 10.877287 0.371369 0.824002 0.324251
ENSG00000092621 PHGDH HNSC Del 17.181826 0.158457 0.417758 0.239464
ENSG00000092621 PHGDH PCPG Del 17.707156 0.271999 0.697715 0.679012
ENSG00000092621 PHGDH BLCA Amp 1.973005 0.208812 0.508037 0.274510
ENSG00000092621 PHGDH MESO Del 1.316827 0.149331 0.585785 0.195402