Ensembl ID ENSG00000091436 Gene ID 51776 Accession 17797
Gene Symbol MAP3K20 Alias pk;AZK;MLT;MRK;ZAK;CNM6;MLK7;MLTK;SFMMP;mlklak;MLTKbeta;MLTKalpha Full Name mitogen-activated protein kinase kinase kinase 20
Position 2 : 173075435 - 173268015 Length 192581 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ENSG00000091436 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000091436 0.72 6.59e-17 KIRC
ENSG00000091436 -3.1 5.25e-33 BLCA
ENSG00000091436 -1.5 2.41e-80 BRCA
ENSG00000091436 -1.2 2.57e-23 PRAD
ENSG00000091436 -1.7 9.74e-16 STAD
ENSG00000091436 -2.4 1.23e-73 UCEC
ENSG00000091436 -0.6 1.59e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000091436 cancer 15172994
ENSG00000091436 tumor 23319595
ENSG00000091436 cancer 28928839
ENSG00000091436 gastric cancer 29428732
ENSG00000091436 ovarian cancer 30249278
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000091436 MESO 0.00046 high
ENSG00000091436 SARC 0.017 low
ENSG00000091436 STAD 0.035 high
ENSG00000091436 UVM 0.00096 high
ENSG00000091436 ACC 0.0041 high
ENSG00000091436 LUSC 0.0034 high
ENSG00000091436 HNSC 0.012 high
ENSG00000091436 KICH 0.018 high
ENSG00000091436 LUAD 0.039 high
ENSG00000091436 THYM 0.0022 high
ENSG00000091436 BRCA 0.00044 high
ENSG00000091436 COAD 0.0015 low
ENSG00000091436 ESCA 0.012 low
ENSG00000091436 BLCA 0.002 high
ENSG00000091436 LAML 0.017 high
ENSG00000091436 CESC 0.0014 high
ENSG00000091436 LIHC 0.0097 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000091436 KIRP Amp 1.172854 0.067148 0.628338 0.184028
ENSG00000091436 HNSC Amp 3.404061 0.175714 0.534319 0.201149
ENSG00000091436 PRAD Del 2.100720 0.089121 0.441338 0.117886
ENSG00000091436 OV Amp 1.928430 0.372151 0.599753 0.423143