Ensembl ID ENSG00000091140 Gene ID 1738 Accession 2898
Gene Symbol DLD Alias E3;LAD;DLDD;DLDH;GCSL;PHE3;OGDC-E3 Full Name dihydrolipoamide dehydrogenase
Position 7 : 107891164 - 107931730 Length 40567 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

ENSG00000091140 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000091140 DLD -0.9 5.86e-31 KIRC
ENSG00000091140 DLD -0.5 1.82e-12 HNSC
ENSG00000091140 DLD -0.3 6.93e-11 BRCA
ENSG00000091140 DLD 1.01 2.24e-14 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000091140 DLD gastric cancer 22490893
ENSG00000091140 DLD tumor 24612826
ENSG00000091140 DLD endometrial cancer 25202086
ENSG00000091140 DLD cancer 30872792
ENSG00000091140 DLD cancer 31601880
ENSG00000091140 DLD head and neck cancer 31931284
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000091140 DLD STAD 0.01 low
ENSG00000091140 DLD UCEC 0.0095 high
ENSG00000091140 DLD THCA 0.0046 high
ENSG00000091140 DLD LUSC 0.038 low
ENSG00000091140 DLD KIRP 0.0013 low
ENSG00000091140 DLD LUAD 0.013 high
ENSG00000091140 DLD BRCA 0.0018 high
ENSG00000091140 DLD COAD 0.029 low
ENSG00000091140 DLD UCS 0.0038 high
ENSG00000091140 DLD OV 0.043 high
ENSG00000091140 DLD PRAD 0.0056 high
ENSG00000091140 DLD LAML 0.03 low
ENSG00000091140 DLD GBM 0.005 high
ENSG00000091140 DLD SKCM 0.02 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000091140 DLD LAML Del 0.865839 0.033443 0.712673 0.109948
ENSG00000091140 DLD LGG Amp 4.231836 0.090721 0.664440 0.333333
ENSG00000091140 DLD ESCA Amp 2.083417 0.341821 0.622915 0.505435
ENSG00000091140 DLD HNSC Amp 2.403660 0.155943 0.537312 0.287356