Ensembl ID ENSG00000090861 Gene ID 16 Accession 20
Gene Symbol AARS1 Alias AARS;TTD8;CMT2N;DEE29;HDLS2;EIEE29 Full Name alanyl-tRNA synthetase 1
Position 16 : 70251983 - 70289707 Length 37725 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

ENSG00000090861 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000090861 AARS1 0.51 3.85e-11 HNSC
ENSG00000090861 AARS1 0.76 3.26e-21 COAD
ENSG00000090861 AARS1 0.83 7.75e-12 KICH
ENSG00000090861 AARS1 0.69 2.25e-15 LUSC
ENSG00000090861 AARS1 -1.1 2.39e-11 GBM
ENSG00000090861 AARS1 0.55 7.71e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000090861 AARS1 tumor 26388988
ENSG00000090861 AARS1 cancer 27659686
ENSG00000090861 AARS1 tumor 30301907
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000090861 AARS1 MESO 4e-04 high
ENSG00000090861 AARS1 SARC 0.0073 high
ENSG00000090861 AARS1 STAD 0.046 low
ENSG00000090861 AARS1 UCEC 0.032 low
ENSG00000090861 AARS1 ACC 0.036 high
ENSG00000090861 AARS1 LUSC 0.02 high
ENSG00000090861 AARS1 HNSC 0.022 high
ENSG00000090861 AARS1 KIRP 0.0023 high
ENSG00000090861 AARS1 PCPG 0.022 high
ENSG00000090861 AARS1 BRCA 0.014 high
ENSG00000090861 AARS1 COAD 0.0074 high
ENSG00000090861 AARS1 UCS 0.037 low
ENSG00000090861 AARS1 ESCA 0.021 high
ENSG00000090861 AARS1 DLBC 0.039 high
ENSG00000090861 AARS1 KIRC 0.00015 high
ENSG00000090861 AARS1 TGCT 0.0016 high
ENSG00000090861 AARS1 BLCA 0.0065 high
ENSG00000090861 AARS1 GBM 0.012 low
ENSG00000090861 AARS1 SKCM 0.027 high
ENSG00000090861 AARS1 CESC 0.047 high
ENSG00000090861 AARS1 LIHC 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000090861 AARS1 LAML Del 1.466386 0.041379 0.608754 0.036649
ENSG00000090861 AARS1 ACC Amp 0.865367 0.267997 1.091365 0.577778
ENSG00000090861 AARS1 TGCT Amp 0.748581 0.119204 0.578998 0.140000
ENSG00000090861 AARS1 BLCA Amp 0.864524 0.170212 0.491342 0.257353
ENSG00000090861 AARS1 PRAD Del 7.592364 0.133791 0.519141 0.317073
ENSG00000090861 AARS1 UCEC Del 3.579206 0.077533 0.621880 0.280148
ENSG00000090861 AARS1 OV Del 9.439781 0.294690 0.658787 0.768566