Ensembl ID ENSG00000089127 Gene ID 4938 Accession 8086
Gene Symbol OAS1 Alias OIAS;IFI-4;OIASI;IMD100;E18/E16 Full Name 2'-5'-oligoadenylate synthetase 1
Position 12 : 112905856 - 112933219 Length 27364 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

ENSG00000089127 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000089127 OAS1 1.42 1.10e-51 KIRC
ENSG00000089127 OAS1 1.48 4.30e-34 BRCA
ENSG00000089127 OAS1 1.63 4.41e-33 KIRP
ENSG00000089127 OAS1 1.68 3.15e-11 UCEC
ENSG00000089127 OAS1 1.18 4.31e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000089127 OAS1 tumors 17634529
ENSG00000089127 OAS1 cancer 18421422
ENSG00000089127 OAS1 prostate cancer 21638280
ENSG00000089127 OAS1 breast cancer 22520071
ENSG00000089127 OAS1 prostate cancer 23272139
ENSG00000089127 OAS1 breast cancer 25588716
ENSG00000089127 OAS1 cancer 30008265
ENSG00000089127 OAS1 tumor 30814222
ENSG00000089127 OAS1 tumor 31036052
ENSG00000089127 OAS1 breast cancer 31100952
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000089127 OAS1 MESO 0.00051 low
ENSG00000089127 OAS1 SARC 0.00038 low
ENSG00000089127 OAS1 CHOL 0.0067 low
ENSG00000089127 OAS1 UVM 0.021 high
ENSG00000089127 OAS1 PAAD 0.00025 high
ENSG00000089127 OAS1 UCEC 0.0031 high
ENSG00000089127 OAS1 LUSC 0.042 high
ENSG00000089127 OAS1 KICH 0.014 high
ENSG00000089127 OAS1 PCPG 0.047 low
ENSG00000089127 OAS1 THYM 0.011 low
ENSG00000089127 OAS1 COAD 0.015 low
ENSG00000089127 OAS1 ESCA 0.012 high
ENSG00000089127 OAS1 OV 0.036 low
ENSG00000089127 OAS1 DLBC 0.0021 high
ENSG00000089127 OAS1 KIRC 0.029 high
ENSG00000089127 OAS1 TGCT 0.0017 low
ENSG00000089127 OAS1 LAML 0.00076 high
ENSG00000089127 OAS1 CESC 0.046 low
ENSG00000089127 OAS1 LIHC 0.017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000089127 OAS1 CHOL Del 0.852100 0.219537 0.589045 0.222222
ENSG00000089127 OAS1 LUAD Del 0.627377 0.049936 0.277419 0.242248
ENSG00000089127 OAS1 PAAD Del 1.313562 0.058251 0.351339 0.222826
ENSG00000089127 OAS1 BRCA Del 2.911906 0.080798 0.380357 0.191667
ENSG00000089127 OAS1 UCEC Del 0.957741 0.051421 0.401283 0.105751
ENSG00000089127 OAS1 OV Del 2.854692 0.217091 0.564419 0.322971