Ensembl ID ENSG00000087470 Gene ID 10059 Accession 2973
Gene Symbol DNM1L Alias DLP1;DRP1;DVLP;EMPF;OPA5;EMPF1;DYMPLE;HDYNIV Full Name dynamin 1 like
Position 12 : 32679200 - 32745650 Length 66451 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

ENSG00000087470 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000087470 DNM1L -0.4 6.87e-20 KIRC
ENSG00000087470 DNM1L 0.59 3.14e-11 KICH
ENSG00000087470 DNM1L 0.83 7.54e-26 LUSC
ENSG00000087470 DNM1L -1.3 3.39e-18 GBM
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000087470 DNM1L brain tumors 10749171
ENSG00000087470 DNM1L brain tumors 14741701
ENSG00000087470 DNM1L cancer 19525928
ENSG00000087470 DNM1L Tumor 22693511
ENSG00000087470 DNM1L lung cancer 23028930
ENSG00000087470 DNM1L lung cancer 23358890
ENSG00000087470 DNM1L tumor 23957735
ENSG00000087470 DNM1L cancer 24284040
ENSG00000087470 DNM1L breast cancer 24632494
ENSG00000087470 DNM1L cancer 25174275
ENSG00000087470 DNM1L tumor 25730670
ENSG00000087470 DNM1L breast cancer 26114658
ENSG00000087470 DNM1L tumour 26381214
ENSG00000087470 DNM1L tumors 26530043
ENSG00000087470 DNM1L breast cancer 26622184
ENSG00000087470 DNM1L tumor 26942565
ENSG00000087470 DNM1L tumor 27124102
ENSG00000087470 DNM1L tumor 27495873
ENSG00000087470 DNM1L cancer 27509055
ENSG00000087470 DNM1L Breast Cancer 27746856
ENSG00000087470 DNM1L cancer 28408823
ENSG00000087470 DNM1L tumors 28435473
ENSG00000087470 DNM1L breast cancer 28504877
ENSG00000087470 DNM1L breast cancer 29072687
ENSG00000087470 DNM1L tumor 29137373
ENSG00000087470 DNM1L lung cancer 29175207
ENSG00000087470 DNM1L Cancer 29466320
ENSG00000087470 DNM1L Breast Cancer 29622847
ENSG00000087470 DNM1L breast cancer 29700304
ENSG00000087470 DNM1L tumor 29898993
ENSG00000087470 DNM1L breast cancer 29993201
ENSG00000087470 DNM1L ovarian cancer 30049609
ENSG00000087470 DNM1L tumor 30127972
ENSG00000087470 DNM1L colorectal cancer 30258050
ENSG00000087470 DNM1L esophageal cancer 30501006
ENSG00000087470 DNM1L tumor 30894684
ENSG00000087470 DNM1L tumor 31412251
ENSG00000087470 DNM1L Lung Cancer 31417649
ENSG00000087470 DNM1L tumor 31543706
ENSG00000087470 DNM1L tumor 31636463
ENSG00000087470 DNM1L lung cancer 31770286
ENSG00000087470 DNM1L cancer 31914641
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000087470 DNM1L MESO 0.0042 high
ENSG00000087470 DNM1L SARC 0.041 high
ENSG00000087470 DNM1L HNSC 0.0022 high
ENSG00000087470 DNM1L READ 0.0022 low
ENSG00000087470 DNM1L KIRP 0.022 high
ENSG00000087470 DNM1L KICH 0.00061 high
ENSG00000087470 DNM1L LUAD 0.036 high
ENSG00000087470 DNM1L PCPG 0.038 high
ENSG00000087470 DNM1L BRCA 0.039 high
ENSG00000087470 DNM1L COAD 0.014 low
ENSG00000087470 DNM1L UCS 0.026 high
ENSG00000087470 DNM1L OV 0.04 low
ENSG00000087470 DNM1L KIRC 0.00054 high
ENSG00000087470 DNM1L PRAD 0.039 low
ENSG00000087470 DNM1L TGCT 0.036 high
ENSG00000087470 DNM1L BLCA 0.028 low
ENSG00000087470 DNM1L SKCM 0.011 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000087470 DNM1L LUAD Amp 2.522424 0.160186 0.490881 0.319767
ENSG00000087470 DNM1L TGCT Amp 13.173772 0.492147 1.627754 0.960000
ENSG00000087470 DNM1L OV Amp 1.274510 0.350016 0.854392 0.509499