Ensembl ID ENSG00000087365 Gene ID 10992 Accession 10769
Gene Symbol SF3B2 Alias CFM;HFM;Cus1;SF3b1;SAP145;SF3B145;SF3b150 Full Name splicing factor 3b subunit 2
Position 11 : 66052331 - 66069308 Length 16978 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

ENSG00000087365 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000087365 SF3B2 0.29 2.06e-11 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000087365 SF3B2 tumor 15885497
ENSG00000087365 SF3B2 tumor 18973137
ENSG00000087365 SF3B2 tumors 25645911
ENSG00000087365 SF3B2 cancer 30881377
ENSG00000087365 SF3B2 Prostate Cancer 31431456
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000087365 SF3B2 STAD 0.012 low
ENSG00000087365 SF3B2 UVM 0.011 low
ENSG00000087365 SF3B2 PAAD 0.036 high
ENSG00000087365 SF3B2 UCEC 0.047 high
ENSG00000087365 SF3B2 ACC 7e-04 high
ENSG00000087365 SF3B2 KIRP 0.016 low
ENSG00000087365 SF3B2 KICH 0.00053 high
ENSG00000087365 SF3B2 LUAD 0.0071 high
ENSG00000087365 SF3B2 PCPG 0.01 high
ENSG00000087365 SF3B2 THYM 0.027 low
ENSG00000087365 SF3B2 COAD 0.024 high
ENSG00000087365 SF3B2 DLBC 0.037 low
ENSG00000087365 SF3B2 KIRC 0.0019 low
ENSG00000087365 SF3B2 BLCA 0.039 high
ENSG00000087365 SF3B2 LAML 0.0012 high
ENSG00000087365 SF3B2 SKCM 0.037 low
ENSG00000087365 SF3B2 LIHC 0.00013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000087365 SF3B2 CESC Amp 0.807001 0.132513 0.516431 0.118644
ENSG00000087365 SF3B2 HNSC Amp 13.500153 0.323912 0.541172 0.325670
ENSG00000087365 SF3B2 BRCA Amp 1.311052 0.157858 0.501474 0.205556
ENSG00000087365 SF3B2 PRAD Amp 3.108938 0.078545 0.534588 0.093496