Ensembl ID ENSG00000086758 Gene ID 10075 Accession 30892
Gene Symbol HUWE1 Alias MULE;Ib772;LASU1;MRXST;UREB1;HECTH9;URE-B1;ARF-BP1;HSPC272 Full Name HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Position X : 53532096 - 53686719 Length 154624 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]

ENSG00000086758 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000086758 HUWE1 -0.5 1.94e-19 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000086758 HUWE1 colorectal cancer 15567145
ENSG00000086758 HUWE1 tumor 15989956
ENSG00000086758 HUWE1 tumor 16269333
ENSG00000086758 HUWE1 cancer 16641901
ENSG00000086758 HUWE1 lung cancer 19543318
ENSG00000086758 HUWE1 cancer 19876513
ENSG00000086758 HUWE1 Tumour 21522127
ENSG00000086758 HUWE1 breast cancer 21730980
ENSG00000086758 HUWE1 DLBCL 22754359
ENSG00000086758 HUWE1 tumour 23275561
ENSG00000086758 HUWE1 breast cancer 23652204
ENSG00000086758 HUWE1 cancer 23797109
ENSG00000086758 HUWE1 tumor 23847377
ENSG00000086758 HUWE1 breast cancer 24342616
ENSG00000086758 HUWE1 breast cancer 24472556
ENSG00000086758 HUWE1 Cancer 24771979
ENSG00000086758 HUWE1 cancer 25147182
ENSG00000086758 HUWE1 colon cancer 25253726
ENSG00000086758 HUWE1 cancer 25368331
ENSG00000086758 HUWE1 tumor 25543140
ENSG00000086758 HUWE1 cancer 25883150
ENSG00000086758 HUWE1 prostate cancer 26279298
ENSG00000086758 HUWE1 tumor 26498360
ENSG00000086758 HUWE1 tumor 27247392
ENSG00000086758 HUWE1 colorectal cancer 27517746
ENSG00000086758 HUWE1 thyroid cancer 27581931
ENSG00000086758 HUWE1 cancer 27901130
ENSG00000086758 HUWE1 cancer 27934968
ENSG00000086758 HUWE1 tumour 28003334
ENSG00000086758 HUWE1 tumor 28107519
ENSG00000086758 HUWE1 tumor 28193319
ENSG00000086758 HUWE1 ovarian cancer 28687618
ENSG00000086758 HUWE1 breast cancer 28739740
ENSG00000086758 HUWE1 tumor 29221141
ENSG00000086758 HUWE1 breast cancer 29375730
ENSG00000086758 HUWE1 Colorectal cancer 29402894
ENSG00000086758 HUWE1 cancer 29738775
ENSG00000086758 HUWE1 tumor 29858610
ENSG00000086758 HUWE1 tumor 29884741
ENSG00000086758 HUWE1 prostate cancer 29966975
ENSG00000086758 HUWE1 lung cancer 30026863
ENSG00000086758 HUWE1 Prostate Tumor 30042175
ENSG00000086758 HUWE1 colorectal cancer 30088849
ENSG00000086758 HUWE1 tumors 30176860
ENSG00000086758 HUWE1 tumour 30217973
ENSG00000086758 HUWE1 cancer 30261639
ENSG00000086758 HUWE1 cancers 30381291
ENSG00000086758 HUWE1 cancer 30796242
ENSG00000086758 HUWE1 tumor 30877109
ENSG00000086758 HUWE1 tumor 30930989
ENSG00000086758 HUWE1 cancer 30991224
ENSG00000086758 HUWE1 tumors 31001145
ENSG00000086758 HUWE1 prostate cancer 31201299
ENSG00000086758 HUWE1 colon cancer 31251805
ENSG00000086758 HUWE1 lung cancer 31279706
ENSG00000086758 HUWE1 cancer 31392631
ENSG00000086758 HUWE1 cancer 31404287
ENSG00000086758 HUWE1 cancer 31441992
ENSG00000086758 HUWE1 tumor 31528705
ENSG00000086758 HUWE1 tumor 31892969
ENSG00000086758 HUWE1 cancer 31980388
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000086758 HUWE1 MESO 0.0043 high
ENSG00000086758 HUWE1 SARC 0.034 high
ENSG00000086758 HUWE1 UVM 0.0037 low
ENSG00000086758 HUWE1 UCEC 0.01 high
ENSG00000086758 HUWE1 THCA 0.035 high
ENSG00000086758 HUWE1 LGG 0.00028 low
ENSG00000086758 HUWE1 HNSC 0.03 low
ENSG00000086758 HUWE1 READ 0.035 low
ENSG00000086758 HUWE1 KIRP 0.016 high
ENSG00000086758 HUWE1 KICH 0.0071 high
ENSG00000086758 HUWE1 BRCA 0.031 high
ENSG00000086758 HUWE1 ESCA 0.05 high
ENSG00000086758 HUWE1 OV 0.047 high
ENSG00000086758 HUWE1 GBM 0.0097 low
ENSG00000086758 HUWE1 LIHC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency