Ensembl ID
ENSG00000086758
Gene ID
10075
Accession
30892
Gene Symbol
HUWE1
Alias
MULE;Ib772;LASU1;MRXST;UREB1;HECTH9;URE-B1;ARF-BP1;HSPC272
Full Name
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Position
X : 53532096 - 53686719
Length
154624 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
ENSG00000086758 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000086758
HUWE1
-0.5
1.94e-19
KIRC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000086758
HUWE1
colorectal cancer
15567145
ENSG00000086758
HUWE1
tumor
15989956
ENSG00000086758
HUWE1
tumor
16269333
ENSG00000086758
HUWE1
cancer
16641901
ENSG00000086758
HUWE1
lung cancer
19543318
ENSG00000086758
HUWE1
cancer
19876513
ENSG00000086758
HUWE1
Tumour
21522127
ENSG00000086758
HUWE1
breast cancer
21730980
ENSG00000086758
HUWE1
DLBCL
22754359
ENSG00000086758
HUWE1
tumour
23275561
ENSG00000086758
HUWE1
breast cancer
23652204
ENSG00000086758
HUWE1
cancer
23797109
ENSG00000086758
HUWE1
tumor
23847377
ENSG00000086758
HUWE1
breast cancer
24342616
ENSG00000086758
HUWE1
breast cancer
24472556
ENSG00000086758
HUWE1
Cancer
24771979
ENSG00000086758
HUWE1
cancer
25147182
ENSG00000086758
HUWE1
colon cancer
25253726
ENSG00000086758
HUWE1
cancer
25368331
ENSG00000086758
HUWE1
tumor
25543140
ENSG00000086758
HUWE1
cancer
25883150
ENSG00000086758
HUWE1
prostate cancer
26279298
ENSG00000086758
HUWE1
tumor
26498360
ENSG00000086758
HUWE1
tumor
27247392
ENSG00000086758
HUWE1
colorectal cancer
27517746
ENSG00000086758
HUWE1
thyroid cancer
27581931
ENSG00000086758
HUWE1
cancer
27901130
ENSG00000086758
HUWE1
cancer
27934968
ENSG00000086758
HUWE1
tumour
28003334
ENSG00000086758
HUWE1
tumor
28107519
ENSG00000086758
HUWE1
tumor
28193319
ENSG00000086758
HUWE1
ovarian cancer
28687618
ENSG00000086758
HUWE1
breast cancer
28739740
ENSG00000086758
HUWE1
tumor
29221141
ENSG00000086758
HUWE1
breast cancer
29375730
ENSG00000086758
HUWE1
Colorectal cancer
29402894
ENSG00000086758
HUWE1
cancer
29738775
ENSG00000086758
HUWE1
tumor
29858610
ENSG00000086758
HUWE1
tumor
29884741
ENSG00000086758
HUWE1
prostate cancer
29966975
ENSG00000086758
HUWE1
lung cancer
30026863
ENSG00000086758
HUWE1
Prostate Tumor
30042175
ENSG00000086758
HUWE1
colorectal cancer
30088849
ENSG00000086758
HUWE1
tumors
30176860
ENSG00000086758
HUWE1
tumour
30217973
ENSG00000086758
HUWE1
cancer
30261639
ENSG00000086758
HUWE1
cancers
30381291
ENSG00000086758
HUWE1
cancer
30796242
ENSG00000086758
HUWE1
tumor
30877109
ENSG00000086758
HUWE1
tumor
30930989
ENSG00000086758
HUWE1
cancer
30991224
ENSG00000086758
HUWE1
tumors
31001145
ENSG00000086758
HUWE1
prostate cancer
31201299
ENSG00000086758
HUWE1
colon cancer
31251805
ENSG00000086758
HUWE1
lung cancer
31279706
ENSG00000086758
HUWE1
cancer
31392631
ENSG00000086758
HUWE1
cancer
31404287
ENSG00000086758
HUWE1
cancer
31441992
ENSG00000086758
HUWE1
tumor
31528705
ENSG00000086758
HUWE1
tumor
31892969
ENSG00000086758
HUWE1
cancer
31980388
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000086758
HUWE1
MESO
0.0043
high
show
ENSG00000086758
HUWE1
SARC
0.034
high
show
ENSG00000086758
HUWE1
UVM
0.0037
low
show
ENSG00000086758
HUWE1
UCEC
0.01
high
show
ENSG00000086758
HUWE1
THCA
0.035
high
show
ENSG00000086758
HUWE1
LGG
0.00028
low
show
ENSG00000086758
HUWE1
HNSC
0.03
low
show
ENSG00000086758
HUWE1
READ
0.035
low
show
ENSG00000086758
HUWE1
KIRP
0.016
high
show
ENSG00000086758
HUWE1
KICH
0.0071
high
show
ENSG00000086758
HUWE1
BRCA
0.031
high
show
ENSG00000086758
HUWE1
ESCA
0.05
high
show
ENSG00000086758
HUWE1
OV
0.047
high
show
ENSG00000086758
HUWE1
GBM
0.0097
low
show
ENSG00000086758
HUWE1
LIHC
0.013
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
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