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| Ensembl ID | ENSG00000086758 | Gene ID | 10075 | Accession | 30892 |
| Gene Symbol | HUWE1 | Alias | MULE;Ib772;LASU1;MRXST;UREB1;HECTH9;URE-B1;ARF-BP1;HSPC272 | Full Name | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 |
| Position | X : 53532096 - 53686719 | Length | 154624 bases | Strand | Minus strand |
| Status | Confidence | Main interacting RNAs | N.A. | RBP type | Non-canonical_RBPs |
| Summary | This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013] | ||||
ENSG00000086758 Expression In 33 Tumors
| Ensembl ID | Gene symbol | Log2 Foldchange | Pvaue | Cancer |
|---|---|---|---|---|
| ENSG00000086758 | -0.5 | 1.94e-19 | KIRC |
| Ensembl ID | Gene symbol | Cancer types | Pubmed ID |
|---|---|---|---|
| ENSG00000086758 | colorectal cancer | 15567145 | |
| ENSG00000086758 | tumor | 15989956 | |
| ENSG00000086758 | tumor | 16269333 | |
| ENSG00000086758 | cancer | 16641901 | |
| ENSG00000086758 | lung cancer | 19543318 | |
| ENSG00000086758 | cancer | 19876513 | |
| ENSG00000086758 | Tumour | 21522127 | |
| ENSG00000086758 | breast cancer | 21730980 | |
| ENSG00000086758 | DLBCL | 22754359 | |
| ENSG00000086758 | tumour | 23275561 | |
| ENSG00000086758 | breast cancer | 23652204 | |
| ENSG00000086758 | cancer | 23797109 | |
| ENSG00000086758 | tumor | 23847377 | |
| ENSG00000086758 | breast cancer | 24342616 | |
| ENSG00000086758 | breast cancer | 24472556 | |
| ENSG00000086758 | Cancer | 24771979 | |
| ENSG00000086758 | cancer | 25147182 | |
| ENSG00000086758 | colon cancer | 25253726 | |
| ENSG00000086758 | cancer | 25368331 | |
| ENSG00000086758 | tumor | 25543140 | |
| ENSG00000086758 | cancer | 25883150 | |
| ENSG00000086758 | prostate cancer | 26279298 | |
| ENSG00000086758 | tumor | 26498360 | |
| ENSG00000086758 | tumor | 27247392 | |
| ENSG00000086758 | colorectal cancer | 27517746 | |
| ENSG00000086758 | thyroid cancer | 27581931 | |
| ENSG00000086758 | cancer | 27901130 | |
| ENSG00000086758 | cancer | 27934968 | |
| ENSG00000086758 | tumour | 28003334 | |
| ENSG00000086758 | tumor | 28107519 | |
| ENSG00000086758 | tumor | 28193319 | |
| ENSG00000086758 | ovarian cancer | 28687618 | |
| ENSG00000086758 | breast cancer | 28739740 | |
| ENSG00000086758 | tumor | 29221141 | |
| ENSG00000086758 | breast cancer | 29375730 | |
| ENSG00000086758 | Colorectal cancer | 29402894 | |
| ENSG00000086758 | cancer | 29738775 | |
| ENSG00000086758 | tumor | 29858610 | |
| ENSG00000086758 | tumor | 29884741 | |
| ENSG00000086758 | prostate cancer | 29966975 | |
| ENSG00000086758 | lung cancer | 30026863 | |
| ENSG00000086758 | Prostate Tumor | 30042175 | |
| ENSG00000086758 | colorectal cancer | 30088849 | |
| ENSG00000086758 | tumors | 30176860 | |
| ENSG00000086758 | tumour | 30217973 | |
| ENSG00000086758 | cancer | 30261639 | |
| ENSG00000086758 | cancers | 30381291 | |
| ENSG00000086758 | cancer | 30796242 | |
| ENSG00000086758 | tumor | 30877109 | |
| ENSG00000086758 | tumor | 30930989 | |
| ENSG00000086758 | cancer | 30991224 | |
| ENSG00000086758 | tumors | 31001145 | |
| ENSG00000086758 | prostate cancer | 31201299 | |
| ENSG00000086758 | colon cancer | 31251805 | |
| ENSG00000086758 | lung cancer | 31279706 | |
| ENSG00000086758 | cancer | 31392631 | |
| ENSG00000086758 | cancer | 31404287 | |
| ENSG00000086758 | cancer | 31441992 | |
| ENSG00000086758 | tumor | 31528705 | |
| ENSG00000086758 | tumor | 31892969 | |
| ENSG00000086758 | cancer | 31980388 |
| Ensembl ID | Gene symbol | Disease/phenotype | Mutation type | Mutated / Total samples | Literature |
|---|
| Ensembl ID | Gene symbol | Cancer | P-value | Which worse | show |
|---|---|---|---|---|---|
| ENSG00000086758 | MESO | 0.0043 | high | ||
| ENSG00000086758 | SARC | 0.034 | high | ||
| ENSG00000086758 | UVM | 0.0037 | low | ||
| ENSG00000086758 | UCEC | 0.01 | high | ||
| ENSG00000086758 | THCA | 0.035 | high | ||
| ENSG00000086758 | LGG | 0.00028 | low | ||
| ENSG00000086758 | HNSC | 0.03 | low | ||
| ENSG00000086758 | READ | 0.035 | low | ||
| ENSG00000086758 | KIRP | 0.016 | high | ||
| ENSG00000086758 | KICH | 0.0071 | high | ||
| ENSG00000086758 | BRCA | 0.031 | high | ||
| ENSG00000086758 | ESCA | 0.05 | high | ||
| ENSG00000086758 | OV | 0.047 | high | ||
| ENSG00000086758 | GBM | 0.0097 | low | ||
| ENSG00000086758 | LIHC | 0.013 | high |
| Ensembl ID | Gene symbol | Cancer | CNV type | -log10(q-value) | G-score | average amplitude | frequency |
|---|